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Social network analysis and modeling of cellphone-based syndromic surveillance data for ebola in Sierra Leone

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 829-833页

作者： Jia B Kangbai Department of Epidemiology College of Public Health University of Kentucky

Objective:To explore and visualize the connectivity of suspected Ebola cases and surveillance callers who used cellphone technology in Moyamba District in Sierra Leone for Ebola surveillance,and to examine the demographic differences and characteristics of Ebola surveillance callers who make more calls as well as those callers who are more likely to make at least one positive Ebola ***:Surveillance data for 393 suspected Ebola cases(192 males,201 females) were collected from October 23,2014 to June 28,2015 using cellphone *** and Net Draw software were used to explore and visualize the social connectivity between callers and suspected Ebola *** and logistic regression analyses were used to do multivariable ***:The entire social network was comprised of 393 ties and 745 ***(AOR=0.33,95% CI [0.14,0.81]) were associated with decreased odds of making at least one positive Ebola surveillance call compared to ***(IR= 0.63,95% CI [0.49,0.82]) were also associated with making fewer Ebola surveillance calls compared to ***:Social network visualization can analyze syndromic surveillance data for Ebola collected by cellphone technology with unique insights.

关键词： Ebola syndromic Surveillance Social network Analysis Cellphone Outdegree Centrality

Acquired immunity and asymptomatic reservoir impact on frontline and airport ebola outbreak syndromic surveillance and response

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Infectious Diseases of Poverty 2014年第1期3卷 375-384,374页

作者： Ernest Tambo Zhou Xiao-Nong Sydney Brenner Institute for Molecular Bioscience School of Medical Sciences&School of Public HealthUniversity of the WitwatersrandJohannesburgSouth Africa Chinese Center for Disease Control and Prevention National Institute of Parasitic DiseasesShanghai 200025People’s Republic of China WHO Collaborating Centre for Malaria Schistosomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025People’s Republic of China Département de Biochimie et Science Pharmaceutiques Universitédes MontagnesBagangtéRépublique du Cameroun

The number of surveillance networks for infectious disease diagnosis and response has been *** 2000,the World Health Organization(WHO)established the Global Outbreak Alert and Response Network,which has been endorsed by each of the 46 WHO African members since ***,taming the dynamics and plague of the vicious Ebola virus disease(EVD)in African countries has been patchy and erratic due to inadequate surveillance and contact tracing,community defiance and resistance,a lack of detection and response systems,meager/weak knowledge and information on the disease,inadequacies in protective materials protocols,contact tracing nightmare and differing priorities at various levels of the public health *** the widespread acceptance of syndromic surveillance(SS)systems,their ability to provide early warning alerts and notifications of outbreaks is still *** is often too limited for any outbreak,or emerging or otherwise unexpected disease,to be recognized at either the community or the national ***,little is known about the role and the interactions between the Ebola infection and exposure to other syndemics and the development of acquired immunity,asymptomatic reservoir,and Ebola *** lessons be learnt from smallpox,polio,and influenza immunity,and can immunization against these serve as a guide?In most endemic countries,community health centers and disease control and prevention at airports solely relies on passive routine immunization control and reactive syndromic *** frontline and airport Ebola SS systems in West Africa have shown deficiencies in terms of responding with an alarming number of case fatalities,and suggest that more detailed insights into Ebola,and proactive actions,are *** quest for effective early indicators(EEE)in shifting the public and global health paradigm requires the development and implementation of a comprehensive and effective community or regional integrated pandemic p

关键词： Immunity Asymptomatic Reservoir syndromic Surveillance Ebola Response

Phenotypical Aspects of a Familial syndromic Retinitis Pigmentosa

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Open Journal of Ophthalmology 2024年第2期14卷 168-173页

作者： Irma Eneida Dos Santos Joseph Matar Mass Ndiaye Mariama Diambone Badji Alioune Abdoulaye Ndongo Gerauld Akpo Jean Pierre Diagne Gabriel Karold Mendy Mouhamed Attye Aboubacry Sadikh Sow Elhadji Amadou Ba Paule Aida Ndoye Roth Ophthalmology Department of Aristide Le Dantec Hospital Dakar Senegal Pediatric Department of Aristide Le Dantec Hospital Dakar Senegal Radiological Imaging Department of Aristide Le Dantec Hospital Dakar Senegal Ophthalmology Department of Abass Ndao Hospital Dakar Senegal

Aim: To report a familial case of syndromic retinitis pigmentosa identified at Aristide Le Dantec Hospital in Dakar and to describe their clinical characteristics ophthalmic. Observation: We report a sibling group of nine children, four died at a young age from unknown causes. Three children were affected by retinitis pigmentosa, two cases were syndromic. A history of nyctalopia was found in all three affected children. The mean age of onset of decreased visual acuity was 6.6 years. Patient 1 affected by syndromic retinitis pigmentosa had an extraocular sign of cystic dilation of the main bile duct. Patient 2 had myoclonic epilepsy, psychomotor retardation, and the molar tooth sign on cerebral MRI (highly suggestive of Joubert syndrome). The third child had isolated retinitis pigmentosa. Ophthalmological examinations (fundus examination, electroretinogram, and visual evoked potentials) and pediatric examinations in the remaining two children were normal. Discussion and Conclusion: Retinitis pigmentosa is a rare degenerative disease that can be associated with several other malformations, highlighting the importance of screening for associated conditions. It presents a grim functional prognosis and a life prognosis dependent on extraocular manifestations. Molecular biology (karyotyping, next-generation sequencing) could have identified the implicated genes and allowed for a formal diagnosis and genetic counseling.

关键词： Retinitis Pigmentosa syndromic Heredity Ciliopathy

CLINICAL SIMULATED EXPERIMENT ON syndromic STANDARDS OF PULMONARY SYSTEM DISEASES

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Chinese Journal of Biomedical Engineering(English Edition) 1993年第4期2卷 179-179页

作者： Mulin Xu Luoyu Road,Wuban 40074,China

Clinical simulated experiment (CSE) is an intermediate experiment in clinic withmodern functional *** Chinese Medicine (TCM) has a long histo-ry with an unique system of medical theory which has not been standardized and cannot be fully explained by modern natural *** on the syndromic standardsof pulmonary system diseases (SSOPSD) was carried out by following TCM’s theo-

关键词： standardized syndromic explained clinic stimulate spread programs

Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft

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Protein & Cell 2024年第10期15卷 783-789页

作者： Huaxiang Zhao Wenjie Zhong Wenbin Huang Guozhu Ning Jieni Zhang Mengqi Zhang Peiqi Meng Yunfan Zhang Qian Zhang Hongping Zhu Gulibaha Maimaitili Yi Ding Weiran Li Wei Liang Zhibo Zhou Qiang Wang Feng Chen Jiuxiang Lin Department of Orthodontics Peking University School and Hospital of StomatologyBeijing 100081China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi'an Jiaotong UniversityXi'an 710049China College of Stomatology Chongqing Medical UniversityChongqing Key Laboratory of Oral Diseases and Biomedical SciencesChongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher EducationChongqing 400016China Department of Orthodontics Stomatological CenterPeking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Affliated Hospital of Guangdong Medical University&Zhanjiang Key Laboratory of Zebrafish Model for Development and Disease Guangdong Medical UniversityZhanjiang 524023China National Center of Stomatology National Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory for Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijing 100191China Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China Department of Oral and Maxillofacial Surgery Peking University School and Hospital of StomatologyBeijing 100191China The Second Affiliated Hospital of Xinjiang Medical University and Xinjiang Key Laboratory of Neurological Disorder Research Urumqi 830028China Department of Physiology and Pathophysiology School of Basic Medical SciencesXi'an Jiaotong UniversityXi'an 710049China Innovation Centre of Ministry of Education for Development and Diseases Sixth Affliated HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 511442China

Dear Editor,Orofacial cleft(OFC),which includes cleft lip and/or palate(CL/P)and cleft palate(CP),is the most common congenital craniofacial structural disorder,with a prevalence of 1.416%。among live infants worldwide(Massenburg et al.,2021).Nonsyndromic OFC(NSOFC),which does not contain other malformations as syndromic OFC(SOFC),accounts for 70%of cases and is believed to have complex ***,it has been established that genetic factors play a crucial role in the occurrence of NSOFC(Dixon et al.,2011).

关键词： Dixon Whole syndromic

Polydactyly:Clinical and molecular manifestations

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World Journal of Orthopedics 2023年第1期14卷 13-22页

作者： Zisis Kyriazis Panagoula Kollia Ioanna Grivea Nikolaos Stefanou Sotirios Sotiriou Zoe H Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500Greece Department of Genetics and Biotechnology Faculty of BiologyUniversity of AthensAthens 15701Greece Department of Paediatrics Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500Greece Laboratory of Histology and Embryology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500Greece

Polydactyly is a malformation during the development of the human limb,which is characterized by the presence of more than the normal number of fingers or *** is considered to be one of the most common inherited hand *** can be divided into two major groups:Non-syndromic polydactyly or syndromic *** to the anatomical location of the duplicated digits,polydactyly can be generally subdivided into pre-,post-axial,and mesoaxial ***-syndromic polydactyly is often inherited with an autosomal dominant trait and defects during the procedure of anterior-posterior patterning of limb development are incriminated for the final phenotype of the *** are several forms of polydactyly,including hand and foot extra digit *** deformity affects upper limbs with a higher frequency than the lower,and the left foot is more often involved than the *** treatment is always *** the clinical presentation is highly diverse,the treatment combines single or multiple surgical operations,depending on the type of *** research attention that congenital limb deformities have recently attracted has resulted in broadening the list of isolated gene mutations associated with the *** generation sequencing technologies have contributed to the correlation of phenotype and genetic profile of the multiple polydactyly manifestations and have helped in early diagnosis and screening of most nonsyndromic and syndromic disorders.

关键词： Polydactyly Gene syndromic Non-syndromic Preaxial Postaxial

Etiology Profile of the Patients Implanted in the Cochlear Implant Program

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第3期4卷 265-272页

作者： Saroj Mali Divij Sonkhya Mohnish Grover Nishi Sonkhya Department of ENT SMS Medical College and Hospital Jaipur India

Hearing loss in children constitutes a considerable handicap because it is an invisible disability and compromises optimal development and personal achievement of a child. The period from birth to 5 years of life is critical for the development of speech and language;therefore, there is need for early identification and assessment of hearing loss and early rehabilitation in infants and children. Cochlear implants are the treatment of choice for patients with severe to profound sensorineural hearing loss. The goal of the present study was to investigate the different hearing impairment etiologies of patients implanted in cochlear implant program. The hospital based interventional study was conducted in the Department of Otorhinolaryngology, SMS Medical College, Jaipur from July 2011 to Dec. 2013. Present study included 60 prelingually deafened patients who attended ENT OPD and underwent cochlear implant. The most common cause of deafness in our study was acquired (56.66%), which predominantly included perinatal risk factors (64.70%), followed by prenatal risk factors (41.17%). The second common cause was hereditary (26.66%), followed by unknown (16.66%). Infection and ototoxic drug history were the most common risk factors in prenatal and postnatal group. The most common perinatal cause was low birth weight and prematurity.

关键词： Hearing Impairment Cochlear Implant Congenital Sensorineural Hearing Loss Familial Hearing Loss syndromic Hearing Loss

Enhanced Public Health Surveillance for the Sixth Worldwide Uchinanchu Festival Conducted by the Okinawa Prefectural Government, Japan

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Journal of Biosciences and Medicines 2017年第9期5卷 106-115页

作者： Munesada Yamakawa Miyuki Yamauchi Minoru Nidaira Tomoyuki Azuma Tadashi Nakasone Fumie Ando Takahiro Hayamizu Saki Kinjo Yuuki Nakamura Regional Public Health Division Department of Public Health and Medical Care Okinawa Prefectural Government Okinawa Japan Naha City Public Health Center Okinawa Japan Graduate School of Pharmacy Nihon University Chiba Japan

Objective: The Okinawa prefectural government conducted enhanced surveillance for the Sixth Worldwide Uchinanchu Festival, with participation of more than 5300 visitors from abroad, many of whom were Okinawan or of Okinawan descent, for early detection of Zika virus disease and other potential public health threat outbreaks. Method: Enhanced surveillance conducted from 12 October through 13 November involved four surveillance systems, (Nursery) School Absenteeism Surveillance system ((N)SASSy), Prescription Surveillance (PS), and Official syndromic Surveillance (OSS), each of them operates routinely, in addition to case-based and sentinel surveillance under the Infectious Diseases Control Law as Official National Surveillance of Infectious Diseases (ONSID). This enhanced surveillance was conducted for analysis and evaluation, with intensive information sharing among concerned parties. Result: We performed the enhanced surveillance for 33 days from 12 October through 13 November. Information from enhanced surveillance was analyzed and evaluated, and eventually summarized as a daily report. There has been one rubella case at an elementary school in Okinawa City on 20 October and a measles case at an elementary school in Uruma City on 2 November. Those two cases were registered into (N)SASSy on a timely basis. The public health center investigated them quickly, and the measles case was denied later because symptoms did not satisfy with case definition. Discussion: We regard enhanced surveillance as useful to confirm events that might demand a public health response. Moreover, the related including public health centers or medical institutions confirmed the situation as valuable for the administrative structure. However, because almost all (nursery) schools or pharmacies are closed during successive holidays, outbreaks that occur on such days cannot be recognized on a timely basis. More sensitive surveillance for such days, with better preparations for ambulance transfe

关键词： Enhanced Surveillance syndromic Surveillance Mass Gathering School Absenteeism Prescription

CLINICAL SIMULATED EXPERIMENT ON THE SYNDROMI STANDARDS OF PULMONARY SYSTEM DISEASES

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Chinese Journal of Biomedical Engineering(English Edition) 1994年第2期3卷 80-88页

作者： Mulin Xu Qiouqin Wang(Hubei Academy of Traditional Chinese Medicine232 Luoyu Road, Wuhan, 430074, China)

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关键词： : pulmonary diseasel syndromic standards simulated experiment