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Effect of Daikenchuto (TJ-100) on abdominal bloating in hepatectomized patients

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World Journal of Gastrointestinal Surgery 2013年第4期5卷 115-122页

作者： Kazuhiro Hanazaki Kengo Ichikawa Masaya Munekage Hiroyuki Kitagawa Ken Dabanaka Tsutomu Namikawa Department of Surgery Kochi Medical School Kochi University

AIM: To evaluate the clinical usefulness of Daikenchuto (DKT) in hepatecomized patients. METHODS: Twenty patients were enrolled with informed consent. Two patients were excluded because of cancelled operations. The remaining 18 patients were randomly chosen for treatment with DKT alone or combination therapy of DKT and lactulose (n = 9, each group). Data were prospectively collected. Primary end points were Visual Analogue Scale (VAS) score for abdominal bloating, total Gastrointestinal symptoms Rating Scale (GSRS) score for abdominal symptoms, and GSRS score for abdominal bloating. RESULTS: The VAS score for abdominal bloating and total GSRS score for abdominal symptoms recovered to levels that were not significantly different to preoperative levels by 10 d postoperation. Combination therapy of DKT and lactulose was associated with a significantly poorer outcome in terms of VAS and GSRS scores for abdominal bloating, total GSRS score, and total daily calorie intake, when compared with DKT alone therapy. CONCLUSION: DKT is a potentially effective drug for postoperative management of hepatectomized patients, not only to ameliorate abdominal bloating, but also to promote nutritional support by increasing postoperative dietary intake.

关键词： Daikenchuto Hepatic resection Abdominal bloating Visual analogue scale score Gastrointestinal symptoms rating scale score

Non-erosive and uncomplicated erosive reflux diseases:Difference in physiopathological and symptom pattern

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World Journal of Gastrointestinal Pathophysiology 2011年第3期2卷 42-48页

作者： Vittorio Bresadola Gian Luigi Adani Francesco Londero Cosimo Alex Leo Vittorio Cherchi Dario Lorenzin Anna Rossetto Gianmatteo Vit Umberto Baccarani Giovanni Terrosu Dino De Anna Department of Surgery and Transplantation University Hospital of Udine

AIM:To investigate differences in the physiopathological findings(manometry and pH monitoring) and symptoms between cases of non-erosive reflux disease(NERD) and erosive reflux disease(ERD) found positive at 24 h pH monitoring. METHODS:For a total of 670 patients who underwent 24 h pH monitoring,esophageal manometry and upper endoscopy were retrospectively evaluated,assessing the reflux symptoms,manometric characteristics of the lower esophageal sphincter(LES) and esophageal body and the presence or absence of esophagitis and hiatal hernia. Typical and atypical symptoms were also evaluated. For inclusion in the study,patients had to have NERD or ERD and be found positive on pH monitoring(NERD+) . Patients with Gastroesophageal reflux disease(GERD) complicated by stenosis,ulcers or Barrett's esophagus were ruled out. RESULTS:214 patients were involved in the study,i.e. 107 cases of NERD+ and 107 of ERD. There were no significant gender-or age-related differences between the two groups. The ERD group had more cases of hiatal hernia(P = 0.02) and more acid reflux,both in terms of number of reflux episodes(P = 0.01) and as a percentage of the total time with a pH 0.05) . The NERD+ patients presented more often with atypical symptoms(P = 0.01) . CONCLUSION:The NERD+ patients' fewer reflux episodes and the fact that they occurred mainly while in the upright position(unlike the cases of ERD) may be two factors that do not favor the onset of esophagitis. The frequently atypical symptoms seen in patients with NERD+ need to be accurately evaluated for therapeutic purposes because patients with GERD and atypical symptoms generally respond on

关键词： Gastroesophageal reflux disease Non-erosive reflux disease Erosive reflux disease Barrett’s esophagus Reflux symptoms

Clinical presentation predicts the outcome of patients with colon cancer

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World Journal of Gastrointestinal Surgery 2013年第4期5卷 104-109页

作者： Offir Ben-Ishay Zvi Peled Amira Othman Eran Brauner Yoram Kluger Department of General Surgery Rambam Health Care Campus the Ruth and Bruce Rappaport Faculty of Medicine Technion Israel Institute of Technology

AIM: To elucidate the relationship between clinical presentation and outcome. METHODS: A single institution retrospective chart review of patients admitted with the diagnosis of colon cancer. We used univariate and a multivariate analysis to identify symptoms association with mortality. An odds ratio based clinical score was created to evaluate the contribution of the quality of symptoms to outcome. Primary measure of outcome was survival. RESULTS: During the study period, 236 patients met the inclusion criteria. Overall survival was 60.6%, mean follow-up 3.0 years. A bivariate analysis showed that increasing number of symptoms is not associated with mortality. However, a symptom-specific analysis performed using a logistic regression model controlling for age, stage and the duration of complaints revealed that the presence of melena was independently associated with mortality [P = 0.04, odds ratio (OR) 7.4],while rectal bleeding was associated with survival (P = 0.004, OR 3.9). Applying the proposed clinical score to an receiver operating characteristic curve showed that score > 1 had a strong association with mortality. The same logistic regression model was applied. The results showed that a score > 1 was an independent predictor of mortality (P symptoms rather than quantity is correlated with outcome among patients with colon cancer. The proposed clinical scoring system may correctly predict the patient's outcome.

关键词： Colon cancer symptoms Mortality

Efficacy and tolerability of hydrogen carbonate-rich waterfor heartburn

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World Journal of Gastrointestinal Pathophysiology 2016年第1期7卷 171-180页

作者： andré-michael beer ralf uebelhack ute pohl Klinik Blankenstein Ruhr-Universität Bochum45527 HattingenGermany Analyze and Realize GmbH 13456 BerlinGermany

AIM To investigate the efficacy and safety of mineralwater with a high content of hydrogen carbonate inpatients with ***： This open, single-center, single-armclinical pilot study enrolled 50 patients, 18-64 yearsold, who had been suffering from heartburn at leasttwice a week for at least 3 mo before entering thestudy. Pharmacological treatment of heartburn was notpermitted, and patients with severe organic diseaseswere excluded. After a run-in period of one week, theparticipants received 1.5 L of the test water for thefollowing 6 wk; 300 mL with meals t.i.d., the remainderto be drunk throughout the day. During the trial, therewere five visits at the study center （screening, baseline,two interim visits and the final visit）. The efficacyendpoints included incidence and duration of heartburnepisodes per week by patient＇s self-assessment （heartburndiary） as well as changes in symptom severity asper symptom specific questionnaires [Reflux Disease Questionnaire （RDQ）; Quality of Life in Reflux andDyspepsia （QOLRAD）; Gastrointestinal Quality of LifeIndex] and overall health-related quality of life per SF-12（12-question short form） at each visit. At the end of thestudy, patients and investigators independently ratedthe overall efficacy of the test water on a 4-point Likertscale. Safety was assessed by evaluation of adverseevents （AEs）, vital signs （heart rate, blood pressure）and laboratory parameters. Changes from initial to finalexaminations were assessed by the non-parametricWilcoxon test; categorical variables were comparedusing the χ 2 test, and for more than 5 categories, by ***： Twenty-eight participants were men, 22women. The mean age of the patients in the fullanalysis set/intention-to treat population （FAS/ITT） was40.6 years. Forty-two participants completed the studyaccording to the study protocol and formed the perprotocolset （PP population）; 48 participants drank thewater at least once as requested and were analyzedas ITT population.

关键词： Heartburn Hydrogen carbonate-rich mineralwater Open clinical pilot study Patients Regurgitation Gastroesophageal reflux disease symptoms Dyspepsia Blood pressure Tolerability Quality of life

Assessment of cardiovascular risk in diabetes:Risk scores and provocative testing

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World Journal of Diabetes 2015年第4期6卷 634-641页

作者： Teresa Lam Kharis Burns Mark Dennis N Wah Cheung Jenny E Gunton Department of Diabetes and Endocrinology Westmead Hospital Sydney Medical School the University of Sydney Department of Cardiology Royal Prince Alfred Hospital Faculty of Medicine Westmead HospitalUniversity of Sydney St Vincent’s Clinical School University of New South Wales Diabetes and Transcription Factors Group Garvan Institute of Medical Research

Cardiovascular disease(CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus,who have a risk of cardiovascular mortality two to four times that of people without *** individualised approach to cardiovascular risk estimation and management is *** the past decades,many risk scores have been developed to predict ***,few have been externally validated in a diabetic population and limited studies have examined the impact of applying a prediction model in clinical ***,guidelines are focused on testing for CVD in symptomatic *** symptoms or silent ischemia are more common in the diabetic population,and with additional markers of vascular disease such as erectile dysfunction and autonomic neuropathy,these guidelines can be difficult to *** propose an algorithm incorporating cardiovascular risk scores in combination with typical and atypical signs and symptoms to alert clinicians to consider further investigation with provocative *** modalities for investigation of CVD are discussed.

关键词： Diabetes Cardiovascular risk Risk scores Provocative testing Silent ischaemia Atypical symptoms

Strawberry Root Diseases and Control Measures

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Plant Diseases and Pests 2020年第1期11卷 10-12页

作者： Wu Chong Zhang Rong Han Zhen Zhang Qingtian Shandong Institute of Pomology Tai'an 271000China Forestry Bureau of Daiyue District Tai'an 271000China

With the development of strawberry protected cultivation industry, continuous cropping of strawberry is becoming more and more com-mon, and soil-borne diseases are increasingly severe. The paper introduces damage symptoms, pathogenic bacteria and transmission mode of several main root diseases of strawberry, including Verticillium wilt, Fusarium wilt, root rot and bacterial wilt, and put forward corresponding prevention and control measures.

关键词： Strawberry Root diseases Damage symptoms Pathogen Control measures

Study on the feasibility of five tones combined with electric acupuncture therapy for drug rehabilitation

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History & Philosophy of Medicine 2020年第2期2卷 41-46页

作者： Yue-Yao Li Jing-Chao Sun Wei Chen Yi-xiao Wang Yu Xia Jing Zhang School of Acupuncture and Massage Shandong University of Traditional Chinese MedicineJinan 250355China

Objective:To explore the feasibility of five tones combined with electro-acupuncture for drug ***:Search and screen the literature related to drug rehabilitation with musical electrico-acupuncture in PubMed,CNKI,CQVIP and Wanfang data to May 2019,and summarize and analyze the ***:Either music therapy or acupuncture therapy has therapeutic responses respectively,and the combined use of both is more effective than the ***:The combination of five tones and acupuncture is highly feasible for drug rehabilitation.

关键词： Five tones Acupuncture Drug rehabilitation Lingering protracted abstinent symptoms

Identification and Prevention and Control of Scab-anthracnoge of Landscape Plant Fatsia japonica

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Plant Diseases and Pests 2019年第4期10卷 7-9页

作者： Ruan Lingxuan Huizhou Engineering Vocational College

The pathogenic characteristics of scab-anthracnoge of Fatsia japonica was introduced,and the infection cycle,occurrence regularity and main harmful symptoms of the disease were *** is the main method to prevent scab-anthracnoge of ***,and disease-free seedlings should be ***,cultivation management should be strengthened to improve disease resistance of plant,and chemical agents must be timely sprayed in the early incidence stage,in order to achieve the purpose of comprehensive control.

关键词： Scab-anthracnoge Fatsia japonica Damage symptoms Prevention and control

One stop shopⅢ:taxonomic update with molecular phylogeny for important phytopathogenic genera:51–75(2019)

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Fungal Diversity 2019年第5期 77-160页

作者： Ruvishika S.Jayawardena Kevin D.Hyde Eric H.C.McKenzie Rajesh Jeewon Alan J.L.Phillips Rekhani H.Perera Nimali I.de Silva Sajeewa S.N.Maharachchikumburua Milan C.Samarakoon Anusha H.Ekanayake Danushka S.Tennakoon Asha J.Dissanayake Chada Norphanphoun Chuangen Lin Ishara S.Manawasinghe Qian Tian Rashika Brahmanage Putarak Chomnunti Sinang Hongsanan Subashini C.Jayasiri F.Halleen Chitrabhanu S.Bhunjun Anuruddha Karunarathna Yong Wang Department of Plant Pathology Agriculture CollegeGuizhou UniversityGuiyang 550025GuizhouChina Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang RaiThailand Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Landcare Research-Manaaki Whenua Private Bag 92170AucklandNew Zealand Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Faculdade de Ciéncias Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesNo.9 of ShuguanghuayuanzhongluHaidian DistrictBeijing 100097People’s Republic of China College of Life Science and Oceanography Shenzhen University1068Nanhai AvenueNanshanShenzhen 518055China Plant Protection Division ARC Infruitec-NietvoorbijPrivate Bag X5026Stellenbosch 7599South Africa Department of Plant Pathology University of StellenboschPrivate Bag X1Matieland 7602South Africa

This is a continuation of a series focused on providing a stable platform for the taxonomy of phytopathogenic fungi and *** paper focuses on 25 phytopathogenic genera:Alternaria,Capnodium,Chaetothyrina,Cytospora,Cyphellophora,Cyttaria,Dactylonectria,Diplodia,Dothiorella,Entoleuca,Eutiarosporella,Fusarium,Ilyonectria,Lasiodiplodia,Macrophomina,Medeolaria,Neonectria,Neopestalotiopsis,Pestalotiopsis,Plasmopara,Pseudopestalotiopsis,Rosellinia,Sphaeropsis,Stagonosporopsis and *** genus is provided with a taxonomic background,distribution,hosts,disease symptoms,and updated backbone trees.A new database(Onestopshopfungi)is established to enhance the current understanding of plant pathogenic genera among plant pathologists.

关键词： Classification Database Plant pathology Phylogeny Taxonomy symptoms Systematics