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Structural remodeling in related brain regions in patients with facial synkinesis

Neural Regeneration Research 2021年第12期16卷 2528-2533页

作者： Jia-Jia Wu Ye-Chen Lu Mou-Xiong Zheng Xu-Yun Hua Chun-Lei Shan Wei Ding Jian-Guang Xu Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Wound Healing Center Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Trauma and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Facial synkinesis is a troublesome sequelae of facial nerve *** is difficult to recover from synkinesis,despite improved surgical techniques for isolating the peripheral facial nerve ***,it remains unclear whether long-term dysfunction of motor control can lead to irreversible plasticity-induced structural brain *** case-control study thus investigated the structural brain alterations associated with facial *** study was conducted at Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,*** patients with facial synkinesis(2 male and 18 female,aged 33.35±6.97 years)and 19 healthy volunteers(2 male and 17 female,aged 33.21±6.75 years)underwent magnetic resonance imaging,and voxel-based and surface-based morphometry techniques were used to analyze *** was no significant difference in brain volume between patients with facial synkinesis and healthy *** with facial synkinesis exhibited a significantly reduced cortical thickness in the contralateral superior and inferior temporal gyri and a reduced sulcal depth of the ipsilateral precuneus compared with healthy *** addition,sulcal depth of the ipsilateral precuneus was negatively correlated with the severity of *** findings suggest that there is a structural remodeling of gray matter in patients with facial synkinesis after facial nerve *** study was approved by the Ethics Review Committee of the Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,China(approval No.2017-365-T267)on September 13,2017,and was registered with the Chinese Clinical Trial Registry(registration number:ChiCTR1800014630)on January 25,2018.

关键词： brain plasticity cortical thickness depression facial nerve paralysis facial synkinesis peripheral nerve injury sulcal depth structural remodeling surface-based morphometry voxel-based morphometry

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Morphometric changes in the cortex following acute mild traumatic brain injury

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Neural Regeneration Research 2022年第3期17卷 587-593页

作者： Meng-Jun Li Si-Hong Huang Chu-Xin Huang Jun Liu Department of Radiology the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Morphometric changes in cortical thickness(CT),cortical surface area(CSA),and cortical volume(CV) can reflect pathological changes after acute mild traumatic brain injury(m TBI).Most previous studies focused on changes in CT,CSA,and CV in subacute or chronic m TBI,and few studies have examined changes in CT,CSA,and CV in acute m ***,acute m TBI patients typically show transient cognitive impairment,and few studies have reported on the relationship between cerebral morphological changes and cognitive function in patients with m *** prospective cohort study included 30 patients with acute m TBI(15 males,15 females,mean age 33.7 years) and 27 matched healthy controls(12 males,15 females,mean age 37.7 years) who were recruited from the Second Xiangya Hospital of Central South University between September and December ***-resolution T1-weighted images were acquired within 7 days after the onset of m *** results of analyses using Free Surfer software revealed significantly increased CSA and CV in the right lateral occipital gyrus of acutestage m TBI patients compared with healthy controls,but no significant changes in *** acute-stage m TBI patients also showed reduced executive function and processing speed indicated by a lower score in the Digital Symbol Substitution Test,and reduced cognitive ability indicated by a longer time to complete the Trail Making *** increased CSA and CV in the right lateral occipital gyrus were negatively correlated with performance in the Trail Making Test part *** findings suggest that cognitive deficits and cortical alterations in CSA and CV can be detected in the acute stage of m TBI,and that increased CSA and CV in the right lateral occipital gyrus may be a compensatory mechanism for cognitive dysfunction in acute-stage m TBI *** study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University,China(approval No.086) on February 9,2019.

关键词： acute mild brain trauma injury Alzheimer's disease cognitive function cortical surface area cortical thickness cortical volume Free Surfer surface-based morphometry

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Altered cortical morphology in major depression disorder patients with suicidality

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Psychoradiology 2021年第1期1卷 13-22页

作者： Huiru Li Huawei Zhang Li Yin Feifei Zhang Ziqi Chen Taolin Chen Zhiyun Jia Qiyong Gong Huaxi MR Research Center(HMRRC) Functional and molecular imaging Key Laboratory of Sichuan ProvinceDepartment of RadiologyWest China Hospital of Sichuan UniversityChengduChina610041 Department of Psychiatry West China Hospital of Sichuan UniversityChengduChina610041 Department of Nuclear Medicine West China Hospital of Sichuan UniversityChengduChina610041 Psychoradiology Research Unit of Chinese Academy of Medical Sciences ChengduChina610041

Background:Major depressive disorder(MDD)is associated with high risk of suicide,but the biological under-pinnings of suicidality in MDD patients are far from *** neuroimaging studies using voxel-based morphometry(VBM)demonstrated that depressed individuals with suicidal thoughts or behaviors exhibit specific cortical structure *** complement VBM findings,surface-based morphometry(SBM)can pro-vide more details into gray matter structure,including the cortical complexity,cortical thickness and sulcal depth for brain ***:This study aims to use SBM to investigate cortical morphology alterations to obtain evidence for neuroanatomical alterations in depressed patients with ***:Here,3D T1-weighted MR images of brain from 39 healthy controls,40 depressed patients without suicidality(patient controls),and 39 with suicidality(suicidal groups)were analyzed based on SBM to estimate the fractal dimension,gyrification index,sulcal depth,and cortical thickness using the Computational Anatomy *** analyses were performed between clinical data and cortical surface measurements from ***:surface-based morphometry showed decreased sulcal depth in the parietal,frontal,limbic,occipital and temporal regions and decreased fractal dimension in the frontal regions in depressed patients with sui-cidality compared to both healthy and patient ***,in patients with depression,the sulcal depth of the left caudal anterior cingulate cortex was negatively correlated with Hamilton Depression Rating Scale ***:Depressed patients with suicidality had abnormal cortical morphology in some brain regions within the default mode network,frontolimbic circuitry and temporal *** structural deficits may be associated with the dysfunction of emotional processing and impulsivity *** study provides insights into the underlying neurobiology of the suicidal brain.

关键词： major depressive disorder suicidality surface-based morphometry fractal dimension sulcal depth psychoradiology

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