检索结果-南通市图书馆

CASTING: A Potent supramolecular Strategy to Cytosolically Deliver STING Agonist for Cancer Immunotherapy and SARS-CoV-2 Vaccination

引用

CCS Chemistry 2023年第4期5卷 885-901页

作者： Jun-Jun Wu Fang-Yuan Chen Bei-Bei Han Hong-Qing Zhang Lang Zhao Zhe-Rui Zhang Juan-Juan Li Bo-Dou Zhang Ya-Nan Zhang Yu-Xin Yue Hong-Guo Hu Wen-Hao Li Bo Zhang Yong-Xiang Chen Dong-Sheng Guo Yan-Mei Li Key Lab of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education) Department of ChemistryCenter for Synthetic and Systems BiologyTsinghua UniversityBeijing 100084 College of Chemistry Key Laboratory of Functional Polymer MaterialsMinistry of EducationState Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjin 300071 Key Laboratory of Special Pathogens and Biosafety Center for Emerging Infectious DiseasesWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071 University of Chinese Academy of Sciences Beijing 100049 Beijing Institute for Brain Disorders Beijing 100069 Key Laboratory of Innate Immune Biology of Fujian Province Provincial University Key Laboratory of Cellular Stress Response and Metabolic RegulationBiomedical Research Center of South ChinaCollege of Life SciencesFujian Normal UniversityFuzhou 350117

Stimulator of interferon genes,namely STING,an adaptor protein located in the endoplasmic reticulum,has been recognized as a shining target for cancer and infection ***,STING agonists cyclic dinucleotides(CDNs)have shown almost zero efficacy in phase I clinical trials as a monotherapy,likely due to poor cellular permeability and rapid diffusion despite intratumoral *** deficiencies further affect other applications of CDNs,such as pandemic SARS-CoV-2 prevention and ***,we rationally design a supramolecular cytosolic delivery system based on controllable recognition of calixarene,namely CASTING(CAlixarene-STING),to improve CDN druggability,including degradation stability,cellular permeability,and tissue *** efficiently enhances the immunostimulatory potency of CDGSF[a chemically modified cyclic di-GMP(CDG)]to generate an immunogenic microenvironment for melanoma regression,anti-PD-1 response rate increase,and durable memory formation against tumor *** importantly,CASTING displays a superior adjuvant activity on SARSCoV-2 recombinant spike/receptor binding domain vaccines,inducing robust and coordinated T-cell and antibody responses against SARS-CoV-2 infection in ***,the CASTING design represents an innovative advancement to facilitate the clinical translational capability of STING agonists.

关键词： STING agonist cyclic dinucleotides calixarene supramolecular delivery cancer immunotherapy SARS-CoV-2 vaccine adjuvant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：