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Synthesis of Caffeic Acid sulphonamide Derivatives and Preliminary Exploration of Their Biological Applications

Chemical Research in Chinese Universities 2020年第5期36卷 795-803页

作者： PENG Xiaoyu ZHAO Anran HUANG Kelin HU Tingju LIU Burning HUANG Yan CHEN Hailan CHAI Ling LIN Cuiwu School of Chemistry and Chemical Engineeting Guangxi UniversityNanning 530004P.R.China School of Animal Science and Technology Guangxi UniversityNanning 530004P.R.China Laboratory Medicine Department First.Affiliated Hospital of Guangxi Medical UniversityNanning 530021P.R.China Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards Guangxi Institute of Traditional Medical and Pharmaceutical SciencesNanning 530022P.R.China China Academy of Science and Technology Development Guangxi Branch Nanning 530022P.R.China

Stnictural modification of native compounds is an effective way to develop new dmgs with increased pharmacological activities and improved material *** this study,cafteic acid sulphonamide derivatives(CSs)were synthesised by conjugating sulphonamides to the backbone of cafteic *** structures of these derivatives were elucidated by means of Fourier traiisfonn infrared spectroscopy(FTIR),1H NMR,13C NMR,and electrospray ionization mass spectroscopy(ESI-MS).A content determination method was established by ultraviolet *** lipophilicity,2,2-diphenyl-l-picrylhydrazy free radical(DPPH)scavenging capacity,anti-coagulant eitects,anti-bacterial activity,cytotoxicity,in vitro anti-proliterative activity against tumour cells,and the ability of the compounds to promote the proliferation of chondrocytes were *** results indicate that CSs exliibit strong DPPH scavenging activity,high lipophilicity,good anti-coagulant activities,wide anti-bacterial activity range,low cytotoxicity,and an excellent ability to promote chondrocyte proliferation.

关键词： Cafteic acid sulphonamide Lipophilicity Anti-oxidant Cytotoxicity

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Efficacy of oxytetracycline and potentiated sulphonamide oral therapies against Aeromonas hydrophila infection in Nile tilapia Oreochromis niloticus

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Journal of Coastal Life Medicine 2017年第9期5卷 371-374页

作者： Thangapalam Jawahar Abraham Anwesha Roy Roy Beryl Julinta Jasmine Singha Prasanna Kumar Patil Department of Aquatic Animal Health Faculty of Fishery SciencesWest Bengal University of Animal and Fishery SciencesChakgariaKolkataWestBengalIndia Central Institute of Brackishwater Aquaculture Indian Council of Agricultural ResearchRaja Annamalai PuramChennaiTamil NaduIndia

Objective: To assess the efficacy of feeds containing approved antibiotics, viz., oxytetracycline (OTC) or potentiated sulphonamide [(sulphamethoxazole-trimethoprim) SMZ-TMP] at 1 g, 2 g, 3 g and 4 g of respective antibiotics/kg feed at 2% body weight ration in preventing the Aeromonas hydrophila (A. hydrophila) infection in Oreochromis niloticus. Methods: Commercial pellet feed was top dressed with respective antibiotics using 5 mL vegetable oil as a binder. Fish were injected intramuscularly with A. hydrophila at ≈ 6.0 × 107–8.6 × 107 CFU/fish, and fed subsequently with OTC and SMZ-TMP feeds for 10 and 5 days, respectively. Fish mortalities were recorded during the pre-treatment, treatment and post-treatment periods. Results: Highest mortalities (7.42%–8.33%) were observed in challenged and untreated fish. The mortalities observed in fish fed with OTC or SMZ-TMP were 0%–6.66% with decreasing concentrations of antibiotics from 4 to 1 g/kg feed. Significant differences existed in the mortalities among fish fed with different doses of antibiotics (P < 0.05). The relative percent survival values were 20, 40, 40 and 60 for 1 g, 2 g, 3 g and 4 g OTC/kg feed groups, respectively;while in SMZ-TMP fed fish, the respective relative percent survival values were 10, 100, 100, and 100. Conclusions: The fish fed with feed containing 2 g antibiotic/kg at 2% body weight was the lowest concentration that recorded significantly lower mortality (P < 0.05), which could be the treatment of choice for the control of A. hydrophila in Oreochromis niloticus in tropical condition.

关键词： Aeromonas hydrophila Oreochromis niloticus Oxytetracycline Potentiated sulphonamide

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Efficacy of Different Concentrations of Aloe chabaudii Leaf Gel as a Substitute for a Sulfonamide for the Control of Avian Coccidiosis

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Open Journal of Applied Sciences 2013年第7期3卷 430-435页

作者： Marvelous Sungirai Moses Mucheni Lawrence Masaka Department of Livestock and Wildlife Management Midlands State University Gweru Zimbabwe

The objective of this study was to investigate the effectiveness of Aloe chabaudii schonland juice as a potential substitute of sulphonamide drugs and to measure its effects when administered at different concentrations in the control of avian coccidiosis. 30 cobb and 500 broiler chickens were used for the experiment. The broilers were randomised into six groups of five birds each and the groups were assigned to six treatments in a Complete Randomised Design (CRD). Four of the groups were given any one of the following treatments, different concentrations of Aloe (weight/volume: 10%, 20% and 30%) and a sulphonamide. There was a control group which was not given a treatment and one cohort group which was neither infected nor treated. At two weeks of age, 25 of the birds were infected with coccidia via drinking water using infected chicken fecal matter, while the remaining five birds were left uninfected. Infection proceeded for 1 week and after the infection period, fecal oocysts were counted from each individual bird using the McMaster technique. Treatments started one day after the infection and continued for one week after 20 gram samples of fecal matter were taken from each bird per treatment and oocysts were counted. After oocyst counting, all birds were slaughtered and lesion scoring was done on the intestines using the Johnson and Reid technique. Data was analysed for oocysts count in different treatments, fecal egg count reduction, relative risk of coccidiosis and the effectiveness of Aloe concentrations as a substitute for a commercial sulphonamide. The results showed that the concentrations of Aloe used in the experiment were not effective as compared to the sulphonamide in controlling coccidiosis as the fecal egg reduction was below 90% for all concentrations. The relative risk of coccidiosis infection in the farm was found to be 100%, meaning that coccidiosis is a disease of economic importance at the farm. However, there was a reduction in the fecal oocy

关键词： Aloe chabaudii Coccidiosis sulphonamide Efficacy

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