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Energy transfer in solid-state dye lasers based on methyl methacrylate co-doped with sulforhodamine b and crystal violet

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Chinese Physics b 2013年第11期22卷 319-324页

作者： R.G.Geethu Mani M.basheer Ahamed Department of Physics KCG College of Technology Research Centre Bharathiar University Department of Physics B.S. Abdur Rahman University

Laser action in methyl methacrylate （MMA） co-doped with sulforhodamine b and crystal violet dyes was investi- gated. The dye mixture was incorporated into a solid polymeric matrix and was pumped by a 532-nm Nd：YAG laser. Distributed feedback dye laser （DFDL） action was induced in the dye mixture using a prism arrangement both in the donor and acceptor regions by an energy transfer mechanism. Theoretically, the characteristics of acceptor and donor DFDLs, and the dependence of their pulse widths and output powers on acceptor-donor concentrations and pump power, were studied. Experimentally, the output energy of DFDL was measured at the emission peaks of donor and acceptor dyes for different pump powers and different acceptor-donor concentrations. Tuning of the output wavelength was achieved by varying the period of the gain modulation of the laser medium. The laser wavelength showed continuous tunability from 563 nm to 648 nm.

关键词： sulforhodamine b crystal violet distributed feedback dye laser solid state distributed feedbackdye laser

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Effect of Guizhi Fuling capsule and its extracts on human breast cancer cells proliferation

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中国药理学与毒理学杂志 2017年第10期31卷 1013-1014页

作者： Zi-ru YU Li LI Jin-hua WANG Zhen-zhong WANG Wei XIAO Guan-hua DU beijing Key Laboratory of Drug Targets Identification and Drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process Jiangsu Kanion Pharmaceutical CoLtd

ObJECTIVE To evaluate the effect of Guizhi Fuling Capsule active pharmaceutical ingredient(API)and its fractions on human breast cancer cells proliferation by high-throughput screening *** The crude fractions were obtained from the extraction and elution of the API of Guizhi Fuling Capsule,and 929 standard fractions were obtained by the optimal separation *** b(SRb)method was used to evaluate the effects of the Guizhi Fuling capsule API and929 kinds of fractions on the proliferation of human breast cancer cells MCF-7 and *** The Guizhi Fuling capsule API had a strong ability to inhibit the proliferation of MCF-7 cells at high concentration and the ability to inhibit MDA-Mb-231 cells' proliferate at low concentration following 72 h treatment;some samples of 929 fractions(5μg·mL^(-1))was found to have a breast cancer cell growth inhibition rate above 50%,without toxicity on HUVECs *** The API of Guizhi Fuling capsule had significant cytotoxicity effects on these two human breast cancer cells,with significant concentration-and time-dependent manner.

关键词： high throughput screening Guizhi Fuling capsule breast cancer MCF-7 cell MDA-Mb-231 cell sulforhodamine b

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