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Solubility measurement and thermodynamic properties of sulfamonomethoxine in pure solvents and sulfamonomethoxine hydrate in acetone + water binary solvent at different temperature

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Chinese Journal of Chemical Engineering 2021年第10期34卷 196-204页

作者： Yanmin Shen Wenju Liu Paifeng Shi Chao Wang School of Chemistry and Chemical Engineering Henan University of TechnologyZhengzhou 450001China

The experimental solubility of sulfamonomethoxine in six different pure solvents(methanol,ethanol,1-propanol,l-butanol,ethyl acetate and acetone)and sulfamonomethoxine hydrate in acetone+water mixture solvents were measured from 294.55 K to 362.15 K by a laser dynamic method under atmospheric *** results indicated that the solubility data of sulfamonomethoxine increased with temperature increasing in pure solvents and the solubility followed this order:acetone>methanol>ethanol>ethyl acetate>1-propanol>1-butanol,but solubility in ethyl acetate was not affected significantly by *** acetone+water mixture solvent,the solubility of sulfamonomethoxine hydrate increased with temperature and the acetone *** equations were applied to correlate solubility data of sulfamonomethoxine and sulfamonomethoxine hydrate including the modified Apelblat equation,kh equation,Wilson equation,NRTL equation,Van’t Hoff-Jouyban Acree equation and modified Apel-Jouyban-Acree ***,thermodynamic properties DGd,DHdand DSdof sulfamonomethoxine and sulfamonomethoxine hydrate in dissolution process were obtained and discussed with the modified Van’t Hoff equation and Gibbs equation.

关键词： Solubility sulfamonomethoxine sulfamonomethoxine hydrate Thermodynamic properties

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sulfamonomethoxine-induced urinary calculi in pigs

Sulfamonomethoxine-induced urinary calculi in pigs

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中国畜牧兽医学会家畜内科学分会2009年学术研讨会

作者： Wei-Dong Sun~1,Jin-Yong Wang~(1,2),Xiao-Long Wang~(1*) 1.Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls,Nanjing Agricultural University, Nanjing 210095,China 2.College of Agriculture,Hebei University of Engineering,Handan 057150,China

The authors report a case of swine urolithiasis caused by improper administration of sulfamonomethoxine and which was diagnosed by examination of urinary sediments and analyzing the composition of the *** chemical composition of urinary calculi obtained from affected pigs with urolithiasis was further confimed as sulfamonomethoxine by fourier transform infrared(FTIR).It is suggested that appearance of typical fanlike or wheat bunchy crystals in urinary sediments under observation of light-microscope and determination by FTIR for the crystals are helpful in diagnosing sulfa calculi causced swine urolithiasis.

关键词： calculi sulfamonomethoxine pig

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Persistently Upregulated Hippocampal mTOR Signals Mediated by Fecal SCFAs Impair Memory in Male Pups with SMM Exposure in Utero

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Biomedical and Environmental Sciences 2019年第5期32卷 345-356页

作者： ZHU Yi Tian LIU Xin Ji LIU Kai Yong ZHANG Qiang YANG Lin Sheng WEI Rong ZHANG Jing Jing TAO Fang Biao Department of Nutrition and Food Hygiene School of Public HealthAnhui Medical UniversityHefei 230032AnhuiChina Anhui Provincial Key Laboratory of Population Health and Aristogenics Hefei 230032AnhuiChina Hefei Municipal Center for Disease Control and Prevention Hefei 230000AnhuiChina Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032AnhuiChina

Objective To investigate the molecular mechanisms of the adverse effects of exposure to sulfamonomethoxin(SMM) in pregnancy on the neurobehavioral development of male offspring. Methods Pregnant mice were randomly divided into four groups: control‐(normal saline), low‐[10 mg/(***)], middle‐[50 mg/(***)], and high‐dose [200 mg/(***)] groups, which received SMM by gavage daily during gestational days 1‐18. We measured the levels of short‐chain fatty acids(SCFAs) in feces from dams and male pups. Furthermore, we analyzed the mR NA and protein levels of genes involved in the mammalian target of rapamycin(m TOR) pathway in the hippocampus of male pups by RT‐PCR or Western blotting. Results Fecal SCFA concentrations were significantly decreased in dams. Moreover, the production of individual fecal SCFAs was unbalanced, with a tendency for an increased level of total fecal SCFAs in male pups on postnatal day(PND) 22 and 56. Furthermore, the phosphatidylinositol 3‐kinase(PI3 k)/protein kinase B(AKT)/mTOR or mT OR/ribosomal protein S6 kinase 1(S6 K1)/4 EBP1 signaling pathway was continuously upregulated until PND 56 in male offspring. In addition, the expression of Sepiapterin Reductase(SPR), a potential target of m TOR, was inhibited. Conclusion In utero exposure to SMM, persistent upregulation of the hippocampal mTOR pathway related to dysfunction of the gut(SCFA)‐brain axis may contribute to cognitive deficits in male offspring.

关键词： Cognitive deficits sulfamonomethoxine Short-chain fatty acids Mammalian target of rapamycin Sepiapterin reductase

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