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sudden deafness as a prodrome of cerebellar artery infarction:Three case reports

World Journal of Clinical Cases 2022年第15期10卷 4895-4903页

作者： Bang-Liang Li Jia-Yuan Xu Sen Lin Department of Ear Noseand ThroatThe Third Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND To summarize the clinical characteristics of acute cerebral infarction(ACI)in patients with sudden deafness(SD)as the first symptom,improve the awareness of the disease,and help diagnosis and *** SUMMARY From 2019 to 2020,three patients with ACI with SD as the first symptom were admitted to our *** tone audiometry,head magnetic resonance imaging(MRI),vertebral artery and carotid artery B-ultrasound,head and neck computed tomography angiography,and other examinations were *** the treatment of SD,hearing and dizziness were not significantly ***,the patients developed symptoms of related cranial nerve injury,and brain MRI showed cerebral infarction in the cerebellopontine angle *** three cases were transferred to the neurology department for relevant conservative *** Patients with ACI with SD as the first symptom usually attend the otolaryngology *** a diagnosis of SD,which is based on an audiological examination,is made and the corresponding treatment is *** reduce the misdiagnosis of this disease,close attention should be paid to the changes in the patient's clinical symptoms and related auxiliary examinations should be performed,such as brain MRI and cerebrovascular *** should pay attention to the type and severity of hearing loss,the accompanying symptoms,age,high-risk factors for cerebral infarction,and related cranial nerve symptoms in patients with *** the patient's early brain MRI does not show abnormalities,monitoring remains *** head MRI should be analyzed quickly based on the changes in the symptoms of the patient,to make an accurate diagnosis and provide the timely and correct treatment for the patients.

关键词： Acute cerebral infarction Anterior inferior cerebellar artery sudden deafness Case report

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Initial steps on the analysis of the underlying pharmacological mechanisms of Wendan decoction on sudden deafness using network pharmacology and molecular docking

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生物细胞(英文) 2023年第9期47卷 1947-1964页

作者： SHIMING YE YUFENG ZHANG TING LIU CONG WANG ZHENG YAN WANDONG SHE HAIBING HUA Department of Otolaryngology Yizheng People’s HospitalYangzhou211400China Department of Otolaryngology-Head and Neck Surgery Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing210008China Department of Pulmonary and Critical Care Medicine Jiangyin Hospital of Traditional Chinese MedicineJiangyin Hospital Affiliated to Nanjing University of Chinese MedicineJiangyin214400China Department of Gastroenterology Jiangyin Hospital of Traditional Chinese MedicineJiangyin Hospital Affiliated to Nanjing University of Chinese MedicineJiangyin214400China Department of Internal Medicine Jiangyin Hospital of Traditional Chinese MedicineJiangyin Hospital Affiliated to Nanjing University of Chinese MedicineJiangyin214400China

Background:Despite its widespread therapeutic use and effectiveness,the underlying pharmacologic mechanisms of Wendan decoction(WDD)and how it works to treat sudden deafness(SD)remain *** this study,the pharmacological mechanisms of WDD underlying SD were analyzed using network pharmacology and molecular ***:The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)was employed to identify the active compounds and target genes of WDD,and genes associated with SD were screened on five *** conducted Gene Ontology(GO)functional and the Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses.A compound-target network was established using Cytoscape,and the STRING database created a protein-protein interaction(PPI)network to identify the key compounds and ***,a network of crucial compound-target was generated for further molecular docking *** molecular docking simulations of the macromolecular target proteins and their matching ligand molecules,AutoDock Vina and AutoDockTool were ***:TCMSP identified 162 active target genes and 36 active compounds for *** active target genes were compared with the 2271 genes associated with SD to identify 70 intersecting active target genes linked to 34 active *** GO functional enrichment and KEGG pathway enrichment analyses were undertaken,and compound–target,and PPI networks were *** key compounds and protein targets were identified and integrated to form a key compound–target ***,molecular docking was performed to investigate the interactions of the protein targets with their respective ***:This study highlights the mechanisms of multi-compounds,targets,and pathways of WDD acting on SD and provides further evidence of crucial compounds and their matching target proteins of WDD acting on SD.

关键词： Wendan decoction sudden deafness Network pharmacology Molecular docking

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Current State of Clinical Studies on Diagnosis and Treatment of sudden deafness in China

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Journal of Otology 2006年第1期1卷 22-24页

作者： YU Yaping, YANG Shiming, GUO Wei, YANG Weiyan, GU RuiDepartment of Otolaryngology, Head and Neck Surgery, Institute of Otolaryngology, Chinese PLAGeneral Hospital, Beijing 100853, China. Department of Otolaryngology Head and Neck Surgery Institute of Otolaryngology Chinese PLA General Hospital Beijing 100853 China.

Objective To evaluate the current status of clinical studies on diagnosis and treatment of sudden deafness (SD) in China by retrospective reviewing articles on SD published in Chinese journals in the past 5 years. Special attention is given to whether the diagnosis and treatment standards established in 1996 by the otolaryngology branch of Chinese Medical Association (the'1996 standard') were followed. Methods The terms of 'sudden deafness' and 'treatment' were used as the keywords in searching articles published between 2000 and 2004 in the Chinese biomedicine literature database and Chinese journal network. Principles of evidence-based medicine were applied in reviewing the articles. Results Two hundreds and thirty- four articles were identified, including 176 between 2000 and 2002 and 58 between 2003 and 2004. Among the 176 articles published between 2000 and 2002, effects of medications were studies in 126 articles, of which only 26 (20.6%) followed the'1996 standards'. Eighty-nine (70.6%) were reported based on controlled clinical trials (CCT) and 36 (28.5%) met the criteria of randomized controlled trails (RCT). Of the 58 articles published between 2003 and 2004, drug effects were evaluated in 25 articles, which were all based on the '1996 standards'. However, there lacked placebo control, follow-up data or statistical analysis in these papers. Only 6 articles reported side-effects from pharmacological treatment. Conclusions While a significant number of articles on SD were published in the past 5 years, the '1996 standards' were followed only in a small number of them. The standards may not be appropriate in guiding research and need to be modified for improved guidance to SD management. Multi-center, RCTs should be a crucial part in studies on SD.

关键词： sudden deafness therapy evidence-based medicine randomized controlled trails

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Diuretic Agents in Treatment of sudden deafness

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Journal of Otology 2008年第1期3卷 35-38页

作者： JI Chang-you LI Hong-tao ZHOU Ding-rong CHEN Ji-chuan WANG Yi-nan GUAN Li-qian ZHANG Min Department of Otolaryngology-Head and Neck Surgery Daping Hospital Institute of Surgery ResearchThird Military Medical UniversityChongqing 400042China

Objective To study the role of diuretic agents in treating sudden deafness (SD) and explore the possibility of endolymphatic hydrops as a potential cause of SD. Methods Twenty-eight SD cases were reviewed. In 23 cases, treatment was initiated with routine agents. Diuretic agents were later added in 8 of these cases that failed to respond to routine treatment agents. Diuretic agents were included in the initial treatment in the rest 5 cases. In total, 13 cases received diuretics in addition to routine treatment agents and 15 cases received conventional treatment only. Results In the 8 cases who received diuretics after failed conventional treatments, 4 showed hearing improvement, whereas all 5 cases in which diuretics were included in the initial treatment demonstrated hearing improvement. Conclusion These results suggest a possible role of endolymphatic hydrops in the pathophysiologic course of SD. Diuretics should be considered when clear indications exist with no conflicts to other medical conditions.

关键词： sudden deafness Endolymphatic hydrops Diuretics

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Concurrent symptoms and disease conditions in sudden deafness

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Journal of Otology 2010年第1期5卷 20-23页

作者： ZHANG Xiao-tong1, SUN Bin1, ZENG Wen-Juan1, XU Min1, WEI Jun-rong1 1. Department of Otolaryngology-Head Neck Surgery, the Second Affiliated Hospital of Medical College, Xian Jiao Tong University, Xian Shaanxi 710004, China Department of Otolaryngology–Head Neck Surgery the Second Affiliated Hospital of Medical College Xian Jiao Tong University Xian Shaanxi 710004 China

Objective To study concomitant symptoms and disease conditions in sudden deafness. Methods Clinical data of 418 cases of sudden deafness treated in this department from 2000 to 2007 were reviewed. Results Of the 418 cases, 201 were males and 217 were females. Right ear was involved in 184 cases and left ear in 191 cases. Bilateral involvement was seen in 43 cases. The average age was 44.1 years. Tinnitus was reported in 369 cases (88.3%) either before or after hearing loss, of which 64.5% was of low pitch, 27.1% of high pitch and 8.4% of mixed tones. Constant tinnitus was reported in 83% of the cases, and muffled feelings in 33.3% of the cases. Hearing loss was the only complaint in 221 cases (52.9%). Dizziness was reported in 77 cases (18.4%) and vertigo attacks in 120 cases (28%). Hypertension, coronary artery disease and diabetes were found in 19.6% of 418 cases and hyperlipidemia in 54.5% of 211 cases. CT and / or MRI data were available in 147 cases, with positive findings in 18 cases (12.3%): 2 with acoustic neuroma (1.36%); 4 with emphraxis in the basal ganglia, cerebellum, temporal lobe or parietal lobe, and 12 with poor pneumatization of ipsior contralateral mastoid cells. Conclusion In this case series of sudden deafness, low-pitch constant tinnitus was a common complaint. Most of the studied cases presented with simple hearing loss. Vertigo attacks were more common than dizziness in this group of patients. The most common concomitant disorder was hyperlipidemia, especially high triglycerides. Imaging studies are important in managing sudden deafness in ruling out acoustic neuroma and other intracranial diseases.

关键词： sudden deafness Constituent ratio Concomitant disorder

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Outcomes of treatment of sudden deafness using different Protocols:a retrospective analysis of 104 cases

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Journal of Otology 2010年第1期5卷 1-3页

作者： LIU Rong-rong, ZHOU Ding-rong , JI Chang-you, CHEN Ji-chuan Department of Otorhinolaryngology Head and Neck Surgery, Institute of Surgery Research, Third Affiliated Hospital, Third Military Medical University of Chinese PLA ,Chongqing 400042, China Department of Otorhinolaryngology Head and Neck Surgery Institute of Surgery Research Third Affiliated Hospital Third Military Medical University of Chinese PLA Chongqing 400042 China

Objective To compare different treatment protocols for sudden deafness(SD), for the purpose of identifying an appropriate approach to SD. Methods A total of 104 patients with diagnosis of sudden hearing loss treated from Jan 2006 to December 2008 were included in this study, of which 31 received the typical pharmaceutical treatment (groupⅠ), 40 received the typical pharmaceutical treatment plus polarized liquid (GroupⅡ) and 33 received the hyperbaric oxygen in addition to the treatment included in Group Ⅱ(Group Ⅲ). Results The total improvement rate (67.74%, 62.50% and 75.76% for Groups Ⅰ, Ⅱ and Ⅲ respectively) was not statistically different between the three groups (P > 0.05). Conclusion The three treatment protocols are similar when judged by the treatment outcomes in SD, neither being superior to the others. The two important factors that appear to influence treatment outcomes are the audiogram pattern and duration of hearing loss before seeking treatment. Patients with upsloping or peak-type audiograms and treated within 7 days from the onset have better prognosis than others.

关键词： sudden deafness Therapeutic Effect Prognosis

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Traditional Chinese Medicine Nursing Protocols for sudden deafness( sudden Sensorineural Hearing Loss)

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中西医结合护理（中英文） 2018年第6期4卷 1-6页

sudden deafness is one of the commonest acute symptoms in *** recent years,the incidence of sudden deafness is on the rise all over the world,but its etiology is still unclear,and the prognosis is greatly *** Chinese medicine(TCM)believes that the onset of sudden deafness is related to the liver,gallbladder,heart and triple energizer *** article mainly explored the key points of common syndromes,TCM nursing methods and health guidance of sudden deafness.

关键词： sudden deafness hearing loss tinnitus dizziness nursing of traditional Chinese medicine

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Clinical observation on the different frequency hearing damages in sudden deafness treated by electroacupuncture combined with western medicine comprehensive therapy

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World Journal of Acupuncture-Moxibustion 2012年第2期22卷 22-27页

作者：邱玲郑旭谢芳张敏张吉袁松柏曾光志成都市中西医结合医院疼痛科中国四川成都610041 南充市中医院成都中医药大学附属医院针灸学校四川省凉山州德昌县中医院

Objective To compare the difference in the clinical efficacy on the different frequency hearing damages for the patients with sudden deafness between the comprehensive therapy of electroacupuncture and western medicine and the simple western medicine comprehensive therapy. Methods Fifty-eight cases were randomized into an acupuncture plus medication group （28 cases, 32 damaged ears） and a western medicine group （30 cases, 34 damaged ears）. In the acupuncture plus medication group, the comprehensive therapy of electroacupuncture and western medicine was used. The main points were ěrmén （耳门 TE 21）, Tīnggōng （听宫 SI 19）, Tīnghuì （听会 GB 2）, Yìfēng （翳风 TE 17）, etc. The western medicine therapy was the comprehensive treatment with vasodilators, the medicines for promoting nerve function and releasing inner ear edema and hyperbaric oxygen. In the western medicine group, the western medicine comprehensive therapy was adopted. 10-day treatment made one session. Two sessions of treatment were required. In 1 or 2 sessions of treatment, the efficacy was observed, the electric audiometry was evaluated. Additionally, the blood routine and liver and kidney functions were detected. Results The total effective rate was 50.0% （16/32） in the acupuncture ＋ medication group and was 55.9% （19/34） in the western medicine group. The efficacies were similar between the two groups （P〉0.05）. In 1 and 2 sessions of treatment, at 250 Hz, 500 Hz and 1 kHz, the electric audiometry values in either group were recovered significantly as compared with those before treatment （all P〈0.01）. At 2 kHz, in 1 and 2 sessions of treatment, the improvements of the electric audiometry values were significant as compared with those before treatment in the acupuncture plus medication group separately （P〈0.05, P〈0.01）. At 4 kHz, the differences were not significant statistically before and after treatment in either group （all P〉0.05）. There were no abnormalities in the blood routine and liver and kidney function d

关键词： sudden deafness nerve deafness electroacupuncture hearing different frequencies

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Clinical Efficacy of Hyperbaric Oxygen Therapy at Different Pressures in the Treatment of sudden deafness

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Proceedings of Anticancer Research 2022年第2期6卷 39-42页

作者： Xinli Feng Shuang Dong Jun Wang Jie Yang Yamei Wang Dahui Zhang Guangjun Peng Jinhua Luo Affiliated Hospital of Hebei University Baoding 071000Hebei ProvinceChina College Hospital of Shijiazhuang University Shijiazhuang 050000Hebei ProvinceChina

Objective:To analyze the efficacy of hyperbaric oxygen at different pressures in the treatment of sudden ***:Eighty-two patients with sudden deafness treated in the Affiliated Hospital of Hebei University from September 2019 to September 2021 were selected as the research *** patients were randomly divided into study group 1 and study group 2,and they were treated with hyperbaric oxygen on the basis of routine treatment,in which the pressure used was 1.8 ATA and 2.2 ATA,*** was delivered via the pressure stabilizing mask for 60 *** patients received two courses of treatment,each lasting 10 *** changes in hearing(pure tone audiometry)and the clinical efficacy of both the groups were compared before and after *** data obtained were statistically analyzed using SPSS ***:The total effective rate of study group 1 was 90.00%,while that of study group 2 was 76.19%.The differences between the two groups were statistically significant(psudden deafness treated with hyperbaric oxygen,the clinical efficacy of 1.8 ATA is more significant than that of 2.2 ATA.

关键词： sudden deafness Hyperbaric oxygen therapy Different pressures Clinical efficacy

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The Clinical Effects of Hyperbaric Oxygen in the Treatment of sudden deafness

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Journal of Clinical and Nursing Research 2021年第4期5卷 242-245页

作者： Xinli Feng Ying Chang Hyperbaric Oxygen Treatment Room Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Gastroenterology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

Objective:To observe the clinical effect of hyperbaric oxygen in the treatment of sudden ***:Ninety-six patients with sudden deafness diagnosed by the otolaryngology department were divided into 2 groups which comprised of 48 patients in the conventional treatment group and the other 48 patients in the hyperbaric oxygen treatment *** groups were treated with methylcobalamin,vitamin B1,and ginkgo biloba *** patients in the hyperbaric oxygen treatment group were given hyperbaric oxygen therapy of 2.0 ATA once a *** course of treatment lasted 10 days and after two courses of treatment,the clinical efficacies of the two groups were ***:After two courses of treatment,the effect of treatment in the hyperbaric oxygen treatment group was significantly better than that of the conventional treatment ***:Hyperbaric oxygen therapy can effectively improve the hearing level of patients with sudden deafness and the overall effective rate of treatment.

关键词： sudden deafness Hyperbaric oxygen Clinical effect

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