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Pulsed radiofrequency alleviated neuropathic pain by down-regulating the expression of substance P in chronic constriction injury rat model

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Chinese Medical Journal 2020年第2期133卷 190-197页

作者： Jing-Ai Wang Shao-Ning Niu Fang Luo Department of Anesthesiology Plastic Surgery HospitalChinese Academy of Medical ScienceBeijing 100144China Department of Anesthesiology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Pain Management Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China

Background:Pulsed radiofrequency(PRF),as a non-invasive treatment of neuropathic pain(NP),has been widely administered clinically.Previous studies have shown that PRF has the potential to improve hyperalgesia in animal models of NP.However,there have been few reports to clarify whether the mechanism of PRF treatment of NP involves intervention in the expression of substance P(SP).Therefore,this study administered PRF treatment to chronic constriction injury(CCI)model rats and observed the sciatic nerve mechanical pain threshold and SP expression in the spinal cord to explore the mechanism of PRF treatment.Methods:A total of 96 Sprague-Dawley rats were randomly divided into the sham-surgery-sham-treatment group(S-S group),the sham-surgery-PRF group(S-P group),the CCI-sham-treatment group(C-S group),and the CCI-PRF group(C-P group).The C-S group and the C-P group underwent sciatic nerve CCI,while the other groups received a sham operation.At 14 days after the operation,the C-P group and the S-P group were treated with PRF for 300 s.We recorded the hindpaw withdrawal threshold(HWT)and the thermal withdrawal latency(TWL)of rats in the various groups at baseline,before treatment(0 days),and at 1,7,14,and 28 days after treatment.L4 to L6 spinal cord tissues were taken before treatment(0 days)and 1,7,14,and 28 days after treatment.The transcription and translation of SP were measured by quantitative polymerase chain reaction and Western blotting,respectively.Results:The HWT and the TWL in the C-P group 28 days after PRF treatment were significantly higher than those in the C-S group(95%confidence interval[CI]:5.84–19.50,P<0.01;95%CI:2.58–8.69,P=0.01).The expression of SP in the C-P group 28 days after PRF treatment was significantly lower than that in the C-S group(95%CI:1.17–2.48,P<0.01).Conclusions:PRF may alleviate CCI-induced NP by down-regulating the expression of SP in the spinal cord of CCI model rats.

关键词： Pulsed radiofrequency Chronic constriction injury Sciatic nerve substance P

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Regulatory effects of Poria on substance and energy metabolism in cold-deficiency syndrome compared with heat-deficiency syndrome in rats

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Chinese Journal of Natural Medicines 2018年第12期16卷 936-945页

作者： HAN Xue-Ying WANG Ya-Nan DOU De-Qiang College of Pharmacy Liaoning University of Traditional Chinese Medicine

Recent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling(FL) in traditional Chinese medicine(TCM), in terms of its effects on the substance and energy metabolism in rat models of cold-deficiency and heat-deficiency syndromes, compared with Aconiti Lateralis Radix Praeparaia, called Fuzi(FZ) in TCM, with hot property, and Anemarrhenae Rhizoma, called Zhimu(ZM) in TCM, with cold property, as reference drugs, respectively. The appearance score, toe and rectal temperatures of the animals treated were assessed at different time points. Several indices in vivo correlated with substance and energy metabolism(glucokinas, phosphoglycerate kinase, cytochrome c reductase, cytochrome c oxydase, and Na^+-K^+-ATPase), endocrine system(triiodothyronine, thyroxine, and 17-hydroxycorticosteroid), nervous system(acetylcholin esterase), and cyclic nucleotide system were determined. The changes in appearance score and indices in vivo suggested the successful establishment of cold-deficiency and heat-deficiency syndrome models. FZ reversed the decreased levels of indices(substance and energy metabolism and endocrine system) and alleviated the syndrome of cold-deficiency model, and ZM showed obviously therapeutic effect on heat-deficiency syndrome(appearance score, substance and energy metabolism, and endocrine system). FL could alleviate cold-deficiency syndrome and raise the decreased levels of glucokinas, phosphoglycerate kinase, cytochrome c reductase and triiodothyronine in cold-deficiency model, but had no significant effect on heat-deficiency syndrome. Drug property of FL was inferred as trending to "flat and warm", which still need further study. It was advisable to adopt both cold-deficiency and heat-deficiency models to study the drugs with "flat" property.

关键词： Poria substance metabolism Energy metabolism Cold-deficiency syndrome Heat-deficiency syndrome

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substance use disorders among older adults: A review of randomized controlled pharmacotherapy trials

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World Journal of Psychiatry 2019年第5期9卷 78-82页

作者： Rajesh R Tampi Aarti Chhatlani Hajra Ahmad Kripa Balaram Joel Dey Ricardo Escobar Thejasvi Lingamchetty Department of Psychiatry and Behavioral Sciences Cleveland Clinic Akron GeneralOhioNH 44106United States Cleveland Clinic Lerner College of Medicine of Case Western Reserve University ClevelandOH 44109United States Savant Care Clinic CaliforniaCA 90277United States Department of Psychiatry MetroHealthClevelandOH 44109United States Case Western Reserve University School of Medicine ClevelandOH 44109United States

substance use disorders(SUDs)are a growing problem among older adults.Acamprosate,disulfiram,and naltrexone are United States Food and Drug Administration(referred to as FDA)approved for the treatment of alcohol use disorder,and buprenorphine is approved for the treatment of opiate use disorder among adults.However,the data on the use of these medications for the treatment of SUDs among older adults are unclear from randomized controlled trials(referred to as RCTs).A review of the literature indicates that there are only two RCTs that evaluated the use of pharmacologic agents for SUDs among older adults(≥50 years).One trial evaluated the use of naltrexone when compared to placebo for the treatment of alcohol use disorder among individuals,50-70 years in age.The other trial evaluated the use of naltrexone or placebo as adjuncts with sertraline in the treatment of alcohol use disorder among individuals older than 55 years in age.Both trials indicated that the use of naltrexone reduced the rates of relapse among older adults with alcohol use disorder.However,we did not identify any RCTs that studied the use of buprenorphine,acamprosate,or disulfiram for SUDs among older adults.Based on available evidence,it would be safe to conclude that limited data indicate some efficacy for naltrexone in the treatment of alcohol use disorder among older adults.However,data from controlled trials on the use of other medications that are FDA approved for the treatment of SUDs among younger adults are nonexistent among older adults with SUDs.

关键词： Older adults substance use Naltrexone Acamprosate Disulfiram Buprenorphine

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Bacteriocin-like inhibitory substance (BLIS) activity of Streptococcus macedonicus MBF10-2 and its synergistic action in combination with antibiotics

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Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1140-1145页

作者： Sharon Edith Grazia Sumayyah Sumayyah Fakhri Subhana Haiti Muhamad Sahlan Nicholas C.K. Heng Amarila Malik Pharmaceutical Microbiology and Biotechnology Research Group Faculty of PharmacyUniversitas IndonesiaUI Campus DepokDepok 16424Indonesia Division of Bioprocess Engineering Faculty of EngineeringUniversitas IndonesiaUI Campus DepokDepok 16424Indonesia research centre for biomedical engineering faculty of engineering universitas indonesiaui campus depok Sir John Walsh Research Institute Faculty of DentistryUniversity of OtagoP.O. Box 56Dunedin 9054New Zealand

Objective: To characterize the bacteriocin-like inhibitory-substances(BLIS) activity of Streptococcus macedonicus MBF10-2 [named BLIS(MBF10-2)], a bacteriocinogenic strain isolated from an Indonesian tofu byproduct.Methods: BLIS(MBF10-2) was obtained by culturing the bacterium, and standard deferred antagonism assays were used to demonstrate its activity. The antibacterial testing of fractions collected by filtration using 3–30 kDa cut-off membrane sizes were carried out by performing well diffusion method.Results: The growth of Micrococcus luteus, Streptococcus pyogenes, Lactococcus lactis,Leuconostoc mesenteroides and Weissella confusa were inhibited by BLIS(MBF10-2).Interestingly, BLIS-containing fractions obtained from sequential application on ultrafiltration membranes indicated that this bacterium Streptococcus macedonicus MBF10-2 could produces at least two antimicrobial peptides activities, one of which is likely to be a lantibiotic peptide. Potential synergistic activity against certain Gram-positive(but not Gram-negative) species when partnered with antibiotics(ampicillin, tetracycline or kanamycin) were observed.Conclusion: Combination of some BLIS(MBF10-2) active fractions with antibiotics(ampicillin, tetracycline or kanamycin) could demonstrate synergistic activities against certain Gram-positive species.

关键词： Bacteriocin-like inhibitory substance Deferred antagonism assay Lantibiotic Protein fractionation Streptococcus macedonicus Well diffusion assay

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Emerging substance class with narrow-band blue/green-emitting rare earth phosphors for backlight display application

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Science China Materials 2019年第1期62卷 146-148页

作者： Andries Meijerink Condensed Matter and Interfaces Debye Institute for Nanomaterials Science Utrecht University

Solid state lighting (SSL)on the basis of phosphorconverted white light-emitting diodes (pc-wLEDs)is rapidly changing the lighting and display industry.New materials and concepts provide light sources and systems that have unmatched performance and/or functionality [1,2].In addition to the well-known application of pcwLEDs in home and office lighting,these efficient white light sources are also increasingly applied as alternative backlight units in liquid-crystal displays (LCDs),where there is a strong focus on improving resolution,wider color gamut,and decreased power consumption [3].

关键词： Emerging substance class narrow-band blue

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Reduction of GABA-and substance P-immunoreactivities in spinal dorsal horn by capsaicin

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Chinese Science Bulletin 1996年第17期41卷 1472-1477页

作者：赵志奇魏锋杨焕乔 Shanghai Brain. Research Institute Chinese Academy of Sciences Shanghai 200031 China Shanghai Brain. Research Institute Chinese Academy of Sciences Shanghai 200031 China γ-aminobutyric acid (GABA)-containing neurons are densely located in laminae Ⅰ-Ⅱof the spinal cord where substance P (SP)-containing primary afferent C fibers terminate. By the antibody microprobe technique we found that capsaicin a chemical irritant selectively activating C fibers significantly produced the release of SP in lamina Ⅱ. The

γ-aminobutyric acid (GABA)-containing neurons are densely located in laminae Ⅰ—Ⅱ of the spinal cord where substance P (SP)-containing primary afferent C fibers terminate. By the antibody microprobe technique, we found that capsaicin, a chemical irritant selectively activating C fibers, significantly produced the release of SP in lamina Ⅱ.

关键词： γ-aminobutyric acid substance P capsaicin spinal dorsal horn C fiber.

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Non-cholinergic late slow excitatory postsynaptic potential, 5-hydroxytryptamine and substance P

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Chinese Science Bulletin 1996年第9期41卷 762-765页

作者：孔德虎黄振信马如纯蔡圣荣裴文芬 Department of Physiology Anhui Medical University Hefei 230032 China Department of Physiology Anhui Chinese Traditional Med. Coll. Hefei 230038 China

It has been recognized that substance P (SP) and 5-hydroxytryptamine (5-HT) maybe the transmitters mediating non-cholinergic late slow excitatory postsynaptic potential(LS-EPSP) in the neurons of guinea pig inferior m... 详细信息

关键词： late slow excitatory postsynaptic potential 5-hydroxytryptamine substance P inferior mesenteric ganglion.

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Anomaly of the Moist Potential Vorticity substance with Mass Forcing and Its Application in Diagnosing Mei-Yu Front Rainfall

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Atmospheric and Oceanic Science Letters 2015年第1期8卷 39-44页

作者： ZHOU Yu-Shu ZHU Ke-Feng ZHANG Zhe Laboratory for Cloud-Precipitation Physics and Severe Storms (LACS) Institute of Atmospheric Physics Chinese Academy of Sciences School of Atmospheric Sciences Nanjing University University of Chinese Academy of Sciences

The effects of precipitation on the moist potential vorticity substance(MPVS) are investigated by analyzing the MPVS with precipitation mass forcing and its impermeability in daily 1°× 1° data of the National Centers for Environmental Prediction/National Center for Atmospheric Research(NCEP/NCAR) over the Yangtze River Basin from 21 June to 2 July 1999. The results show that the positive MPVS anomalies appear mainly along the Mei-yu front, where the maximum MPVS collocates with the maximum surface rainfall. Rain case diagnoses indicate that the MPVS anomaly may be used as a dynamical signal to detect the location and shift of the rain band when its impermeability is considered.

关键词： moist potential vorticity substance mass forcing i

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Participation of substance P in Noxious Stimulus-evoked c-fos Expression in Spinal Cord

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Chinese Science Bulletin 1994年第20期39卷 1725-1729页

作者：阮怀珍李希成蔡文琴李海蒂赵邦云张遐

It was reported that substance P (SP) is an excitatory neurotransmitter released from nociceptive primary afferent nerve terminals,and takes a double-effect part in modulation of pain transmission and analgesia in spi... 详细信息

关键词： substance P c-fos protein spinal cord immunohistochemistry formalin.

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Somatostatin involved in transmission of nociceptive information induced by substance P in the spinal cord

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Chinese Science Bulletin 1997年第5期42卷 426-429页

作者： Ruan, HZ Li, XC Cai, WQ Department of Physiology China Department of Histology and Embryology Third Military Medical College Chongqing China

substance P (SP) and somatostatin (SOM), which were believed to have relation with the transmission of nociceptive information, were distributed commonly in the spinal cord. In the previous study, we observed that SP mainly functioned as an algogenesia in spinal cord and could enhance noxious stimulus-evoked pain response. It was reported that SOM was also

关键词： somatostatin substance P in situ hybridization immunohistochemistry spinal cord.

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