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The classification of ATP-binding cassette subfamily A member 3 mutations using the cystic fibrosis transmembrane conductance regulator classification system

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Pediatric Investigation 2018年第1期2卷 17-24页

作者： Laura Denman Lael M. Yonker Thomas Bernard Kinane Pulmonary Division MassGeneral Hospital for Children Boston MA USA Department of Pediatrics Harvard Medical School Boston MA USA

Importance: The ATP-binding cassette subfamily A member 3 (ABCA3) protein plays a vital role in surfactant homeostasis. Mutations in the ABCA3 gene lead to the development of interstitial lung disease. In the most severe manifestation, mutations can lead to a fatal respiratory distress syndrome in neonates. ABCA3 belongs to the same ATP-binding cassette transporter superfamily as the cystic fibrosis transmembrane conductance regulator (CFTR), the gene that causes cystic fibrosis. Objective: To classify ABCA3 mutations in a manner similar to CFTR mutations in order to take advantage of recent advances in therapeutics. Methods: Sequence homology between the CFTR protein and the ABCA3 protein was established. The region of CFTR that is a target for the new potentiator class of drugs was of particular interest. We performed a literature search to obtain all published mutations that were thought to be disease causing. We classified these mutations using the established CFTR classification system. When possible, we drew on previous experimental classification of ABCA3 mutations. Results: Although the proteins share the same overall structure, only a 19％identity was established between CFTR and ABCA3. The CFTR therapeutic target region has a 22％ homology with the corresponding ABCA3 region. Totally 233 unique protein mutations were identified. All protein mutations were classified and mapped to a schematic diagram of the ABCA3 protein. Interpretation: This new classification system for ABCA3, based on CFTR classification, will likely aid further research of clinical outcomes and identification of mutation-tailored therapeutics, with the aim for improving clinical care for patients with ABCA3 mutations.

关键词： ATP-binding cassette transporter subfamily A Cystic fibrosis Genetics Interstitial lung diseases Newborn Respiratory distress syndrome

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Computational identification and evolutional analysis of Piwi subfamily in 11 Drosophila species

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Insect Science 2008年第6期15卷 537-544页

作者： Xue Zhou Ya-Long Xu Luo-Gen Cheng Fei Li College of Life Science Nanjing Normal University Department of Entomology Nanjing Agricultural University Nanjing China

The complete genome sequences of 11 Drosophila species provide an opportunity to investigate the gene family evolution in closely related species. Drosophila Piwi subfamily, including three members, piwi, Aub and Ago3, has attracted increasing attention as it participates in the biogenesis of piRNA. Here, we identified 33 Piwi homologs from the genome of 11 Drosophila species. The full-length cDNA sequences ofpiwi and Aub genes were obtained by using New GENSCAN Web Server. The Ago3 homologs were difficult regarding full-length information because they had long introns. The genomic structure of Piwi subfamily genes are highly conserved among diverse Drosophila species. Insect piwi and Aub genes have long first introns. The average length of the first intron is 1 284 bp for piwi and 840 bp for Aub, which is much larger than those of other introns （93 bp for Piwi and 54 bp for Aub）. However, this phenomenon is not observed in mammalian piwi genes. We also found that there were abundant repeat sequences in both exons and introns of insect Ago3 genes. Due to recent insertions of long terminal repeat elements in four Drosophila species, part of the third introns exhibit higher conservation than adjacent exons and other introns. An evolutional tree created by Minimum Evolution method indicates that mammalian piwi genes are more closely related to the insect Ago3 Piwi subfamily.

关键词： evolution Drosophila genome intron Piwi subfamily

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A REVISION OF THE SPECIES AND GENERA OF THE subfamily ANISENTOMINAE (Protura:Eosentomidae)

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昆虫分类学报 1984年第1期 72-76页

作者： Zhang Zhiyuan Yin Wenying(Shanghai Institute of Entomology, Academia Sinica)

During a study of the species of Anisentominae,which was erected by Yin in 1983,we have examined and reassessed,in the same time,some of the species of Eosentomon,which lack tarsal sensillae e but have sensillae g we... 详细信息

关键词： subfamily absent assigned genera Guangdong latter length generic segmented Jiangsu

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Fast Fourier Transform-based Support Vector Machine for Prediction of G-protein Coupled Receptor Subfamilies

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Acta Biochimica et Biophysica Sinica 2005年第11期37卷 759-766页

作者： Yan-Zhi GUO Meng-Long LI Ke-Long WANG Zhi-Ning WEN Min-Chun LU Li-Xia LIU Lin JIANG College of Chemistry,Sichuan University,Chengdu 610064,China College of Chemistry Sichuan UniversityChengdu 610064 China

Although the sequence information on G-protein coupled receptors(GPCRs)continues togrow,many GPCRs remain orphaned(i.***.ligand specificity unknown)or poorly characterized with littlestructural information available,so an automated and reliable method is badly needed to facilitate the identifi-cation of novel receptors.In this study,a method of fast Fourier transform-based support vector machinehas been developed for predicting GPCR subfamilies according to protein’s hydrophobicity.In classifyingClass B,C,D and F subfamilies,the method achieved an overall Matthew’s correlation coefficient andaccuracy of 0.95 and 93.3%,respectively,when evaluated using the jackknife test.The method achieved anaccuracy of 100% on the Class B independent dataset.The results show that this method can classify GPCRsubfamilies as well as their functional classification with high accuracy.A web server implementing theprediction is available at http://***/blast/Pred-GPCR.

关键词： G-protein coupled receptor subfamily fast Fourier transform support vector machine prediction

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Molecular phylogeny of Pamphagidae （Acridoidea, Orthoptera） from China based on mitochondrial cytochrome oxidase II sequences

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Insect Science 2011年第2期18卷 234-244页

作者： Dao-Chuan Zhang Hong-Yan Han Hong Yin Xin-Jiang Li Zhan Yin Xiang-Chu Yin College of Life Sciences Hebei University Baoding Hebei Province College of Plant Protection Shandong Agncultural University Taian Shandong Province China

Phylogenetic relationships of Pamphagidae were examined using cytochrome oxidase subunit II （COIl） mtDNA sequences （684 bp）. Twenty-seven species of Acridoidea from 20 genera were sequenced to obtain mtDNA data, along with four species from the GenBank nucleotide database. The purpose of this study was analyzing the phylogenetic relationships among subfamilies within Pamphagidae and interpreting the phylogenetic position of this family within the Acridoidea superfamily. Phylogenetic trees were reconstructed using neighbor-joining （NJ）, maximurn parsimony （MP） and Bayesian inference （BI） methods. The 684 bp analyzed fragment included 126 parsimony informative sites. Sequences diverged 1.0%-11.1% between genera within subfamilies, and 8.8%-12.3% between subfamilies. Amino acid sequence diverged 0-6.1% between genera within subfamilies, and 0.4%-7.5% between subfamilies. Our phylogenetic trees revealed the monophyly of Pamphagidae and three distinct major groups within this family. Moreover, several well supported and stable clades were found in Pamphagidae. The global clustering results were similar to that obtained through classical morphological classification： Prionotropisinae, Thrinchinae and Pamphaginae were monophyletic groups. However, the current genus Filchnerella （Prionotropisinae） was not a monophyletic group and the genus Asiotmethis （Prionotropisinae） was a sister group of the genus Thrinchus （Thrinchinae）. Further molec- ular and morphological studies are required to clarify the phylogenetic relationships of the genera Filchnerella and Asiotmethis.

关键词： Acridoidea cytochrome oxidase II gene molecular phylogeny mtDNA,Pamphagidae subfamily

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CLASSIFICATION AND EVOLUTION OF FAMILY PALEOLIMNADIOPSEIDAE (CONCHOSTRACA)

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中国科学B辑(英文版) 1985年第8期28卷 888-896页

作者：沈炎彬 Nanjing Institute of Gcology and Palaeontology Academia Sinica

Based on sculpture of the valve, the size of umbo and the growth line with or without nodes or spines, etc. the family Palcolimnadiopseidae may be classified into 5 subfamilies (including one new subfamily) and 18 genera (including two new genera). In the present paper the author tries to propose a new schcme of the classification and to discuss the origin and evolution of the family Paleolimnadiopseidae.

关键词： subfamily genera fossil dorsal Permian valve holotype earliest probably Jurassic

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SOME REVISIONS OF PYLONIDAE

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Chinese Journal of Oceanology and Limnology 1990年第2期8卷 109-127页

作者：谭智源陈木宏 Institute of Oceanology Acadenia Sinica Qingdao South China Sea Institute of Oceanology Academia Sinica Guanzhou

The three faces of the Pylonid are similar to one another but actually have obvious differences. Their similarities and obvious differences in dorsal, lateral, and apical views are the criteria for the author in species identification and redefinition of the Subfamilies Diplozonaria and Triplozonaria (6 species in all) and description of 7 new species .

关键词： medullary dorsal longitudinal subfamily actually gates somewhat latter radial sagittal

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SYBR Green I-based product-enhanced reverse transcriptase assay for quantification of retroviral PFV and detection of the divalent cation preference of PFV RT

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Virologica Sinica 2014年第5期29卷 314-317页

作者： Xiaofang Yi Yan Sun Qingmei Liu Zhi Li Wanhong Liu Xiaohua He Linjuan Zhang Yuxin Wang College of Life Sciences Shaanxi Normal University School of Medicine Wuhan University

Dear Editor,Prototype foamy virus(PFV)belongs to the genus Spumavirus in the Spumaretrovirinae subfamily of Retroviridae.Although PFV and HIV have much in common,research into PFV has lagged far behind that into HIV,as PFV appeared to be non-pathogenic both in accidentally infected humans and in experimentally infected animals.In recent decades,however,more attention has been focused on PFV because it seems to

关键词： preference transcriptase subfamily pathogenic quantification divalent belongs behind infected template

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COMPLETE ACCUMULATION POINTS AND COMPACTNESS OF FUZZY SETS

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数学物理学报(英文版) 1988年第3期8卷 323-326页

作者：蒋继光 Dept. of Math. Sichuang Univ. Chengdu

Let A be a fuzzy set in a fuzzy topological space (X,τ) and β∈(0, 1]. We denote by ζ_x~a the fuzzy point defined by ζ_x~a(x)=a and ζ_x~a(y)=0 for eaoh y≠x, where a is called the height of ζ_x~a. A subfamily u of τ is called an open β-cover of A if each fuzzy point in A with height β is quasi-coincident with ([1]) some member of u. By a β-subcover of the open β-cover u of A is meant any subfamily of u that is also an open β-cover of A. A is called β-compact in (X, τ) if every open β-cover

关键词： subfamily topological FUZZY meant neighborhood quasi holds 月闭 infinite 去边

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The expression of T-cell receptor Vβ subfamily in hepatitis B virus-related acute-on-chronic liver failure patients and its clinical significance

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China Medical Abstracts(Internal Medicine) 2014年第1期31卷 39-39页

作者：施文娟 Dept Infect Dis 2nd People's HospLanzhou

Objective To investigate the expression and clinical significance of T-cell receptor(TCR)Vβsubfamily in hepatitis B virus(HBV)-related acute-on-chronic liverfailure(HBV-ACLF)patients.Methods Twenty-eight patients with HBV-ACLF(HBV-ACLF group)and 32patients with chronic hepatitis B flare(CHB-F group),who were treated in The Second People’s Hospital

关键词： subfamily immunosorbent prothrombin interleukin cytokines interferon albumin normalized cholesterol bilirubin

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