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Comprehensive association between plasma phospholipid fatty acids and body subcutaneous-to-visceral adipose tissue distribution in normal weight and overweight populations

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Comprehensive association between plasma phospholipid fatty ...

Transcriptional Features of Cattle Visceral and subcutaneous adipose tissues: A Study of RNA-seq

第十二届全国营养科学大会

作者： Jingjing Jiao jieni Qiu Shankuan Zhu Chronic Disease Research Institute Department of NutritionSchool of Public HealthZhejiang University School of Medicine

目的 The aim was to investigate the association between plasma phospholipid(PPL)fatty acid profiles and fat distribution in subjects.方法 Overall 102 of 1029 Chinese adults stratified by sex and body mass index(BMI)were enrolled,who received questionnaire survey,physical exam and magnetic resonance imaging(MRI)*** PPL fatty acids were analyzed by gas *** fat distribution including subcutaneous adipose tissue(SAT)and visceral adipose tissue(VAT)was measured by MRI.结果 PPL n-3 polyunsaturated fatty acids(PUFA)were inversely associated with SAT in normal weight *** n-6 PUFA were correlated with SAT and VAT in normal weight subjects,while PPL saturated fatty acids(SFA)were positively associated with SAT and VAT in overweight *** regression analysis revealed PPL n-6 PUFA positively correlated with SAT in normal weight subjects,but positively associated with VAT in overweight subjects after multiple covariate *** regression results showed PPL n-6 PUFA levels could be used to estimate the obese state.结论 PPL n-6 PUFA instead of n-3 PUFA and SFA as important predictors positively correlate with body SAT-toVAT distribution.

关键词： plasma phospholipid fatty acids polyunsaturated fatty acids fat distribution subcutaneous adipose tissue visceral adipose tissue magnetic resonance imaging

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Open Journal of Animal Sciences 2022年第3期12卷 441-453页

作者： Xiaoyan Duan Yu Liu Xiaoxiao Zhang Haiyi Zhao Office of Academic Affairs Hebei North University Zhangjiakou China Department of Laboratory Animal Center Hebei North University Zhangjiakou China Key Laboratory of Experimental Animals of Hebei Province Shijiazhuang China Hebei North University Zhangjiakou China

Visceral and subcutaneous are the two major types of bovine adipose tissues, and they show metabolic and functional differences according to their distribution, exploring the transcriptional features of visceral and subcutaneous adipose tissues is necessary. In the present study, we conducted RNA-seq analysis to compare the transcriptome between visceral (great omental) and subcutaneous (backfat) adipose tissues from Chinese Simmental cattle and validate them by qRT-PCR. We found that 5864 genes were differentially expressed between two tissues, including 2979 up-regulated and 2885 down-regulated in visceral adipose tissue. Functional analysis revealed a variety of differentially expressed genes (DEGs) involved in lipid metabolism and immune response processes. This may provide valuable information to further our understanding of the complexity of gene regulation governing the physiology of different fat depots. This work highlighted potential genes regulating lipid metabolism and immune responses;it may contribute to a better understanding of the metabolic and functional differences between visceral and subcutaneous adipose tissues.

关键词： Visceral adipose tissue subcutaneous adipose tissue Transcriptional Features Cattle

Semi-automated segmentation of magnetic resonance images for thigh skeletal muscle and fat using threshold technique after spinal cord injury

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Neural Regeneration Research 2018年第10期13卷 1787-1795页

作者： Mina P.Ghatas Robert M.Lester M.Rehan Khan Ashraf S.Gorgey Department of Spinal Cord Injury and Disorders Hunter Holmes McGuire VA Medical Center Department of Radiology Hunter Holmes McGuire VA Medical Center Department of Physical Medicine and Rehabilitation Virginia Commonwealth University

Magnetic resonance imaging is considered the ＂gold standard＂ technique for quantifying thigh muscle and fat cross-sectional area. We have developed a semi-automated technique to segment seven thigh compartments in persons with spinal cord injury. Thigh magnetic resonance images from 18 men（18–50 years old） with traumatic motor-complete spinal cord injury were analyzed in a blinded fashion using the threshold technique. The cross-sectional area values acquired by thresholding were compared to the manual tracing technique. The percentage errors for thigh circumference were（threshold： 170.71 ± 38.67; manual： 169.45 ± 38.27 cm2） 0.74%, subcutaneous adipose tissue（threshold： 65.99±30.79; manual： 62.68 ± 30.22） 5.2%, whole muscle（threshold： 98.18 ± 20.19; manual： 98.20 ± 20.08 cm2） 0.13%, femoral bone（threshold： 6.53 ± 1.09; manual： 6.53 ± 1.09 cm2） 0.64%, bone marrow fat（threshold： 3.12 ± 1.12; manual： 3.1 ± 1.11 cm2） 0.36%, knee extensor（threshold： 43.98 ± 7.66; manual： 44.61 ± 7.81 cm2） 1.78% and % intramuscular fat（threshold： 10.45 ± 4.29; manual： 10.92 ± 8.35%） 0.47%. Collectively, these results suggest that the threshold technique provided a robust accuracy in measuring the seven main thigh compartments, while greatly reducing the analysis time.

关键词： spinal cord injury magnetic resonance imaging semi-automated segmentation subcutaneous adipose tissue intramuscular fat

Sex-and age-specific associations between abdominal fat and non-alcoholic fatty liver disease:a prospective cohort study

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Journal of Molecular Cell Biology 2023年第11期15卷 33-42页

作者： Hongli Chen Yuexing Liu Dan Liu Yebei Liang Zhĳun Zhu Keqing Dong Huating Li Yuqian Bao Jiarui Wu Xuhong Hou Weiping Jia Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Diabetes InstituteShanghai Key Laboratory of Diabetes MellitusShanghai Key Clinical Center for Metabolic DiseaseShanghai 200233China General Practitioner Teams in Community Health Service Center of Nicheng Pudong New Area DistrictShanghai 201306China CAS Key Laboratory of Systems Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China

Obesity is closely related to non-alcoholic fatty liver disease(NAFLD).Although sex differences in body fat distribution have been well demonstrated,little is known about the sex-specific associations between adipose tissue and the development of *** community-based cohort data,we evaluated the associations between magnetic resonance imaging quantified areas of abdominal adipose tissue,including visceral adipose tissue(VAT)and subcutaneous adipose tissue(SAT),and incident NAFLD in 2830 participants(1205 males and 1625 females)aged 55–70 *** a 4.6-year median follow-up,the cumulative incidence rates of NAFLD increased with areas of VAT and SAT both in males and in *** analyses showed that the abovementioned positive associations were stronger in males than in females,especially in participants under 60 years *** contrast,these sex differences disappeared in those over 60 years ***,the risk of developing NAFLD increased non-linearly with increasing fat area in a sex-specific ***,sex-specific potential mediators,such as insulin resistance,lipid metabolism,inflammation,and adipokines,may exist in the associations between adipose tissue and *** study showed that the associations between abdominal fat and the risk of NAFLD were stratified by sex and age,highlighting the potential need for sex-and age-specific management of NAFLD.

关键词： visceral adipose tissue subcutaneous adipose tissue sex difference NAFLD incidence prospective study

Prepartum dietary energy intake alters adipose tissue transcriptome profiles during the periparturient period in Holstein dairy cows

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Journal of Animal Science and Biotechnology 2020年第2期11卷 410-423页

作者： Andrea Minuti Massimo Bionaz Vincenzo Lopreiato Nicole A.Janovick Sandra L.Rodriguez-Zas James K.Drackley Juan J.Loor Department of Animal Sciences Food and NutritionFaculty of AgricultureFood and Environmental ScienceUniversitàCattolica del Sacro Cuore29122 PiacenzaItaly Animal and Rangeland Sciences Oregon State UniversityCorvallisOR 97330USA Department of Animal Sciences Division of Nutritional SciencesUniversity of IllinoisUrbanaIL 61801USA

Background:The aim of the study was to investigate the effect of energy overfeeding during the dry period on adipose tissue transcriptome profiles during the periparturient period in dairy ***:Fourteen primiparous Holstein cows from a larger cohort receiving a higher-energy diet(1.62 Mcal of net energy for lactation/kg of dry matter;15%crude protein)for ad libitum intake to supply 150%(OVR)or 100%(CTR)of energy requirements from dry off until parturition were *** calving,all cows received the same lactation *** adipose tissue(SAT)biopsies were collected at−14,1,and 14d fromparturition(d)and used for transcriptome profiling using a bovine oligonucleotide *** mining of differentially expressed genes(DEG)between treatments and due to sampling time was performed using the Dynamic Impact Approach(DIA)and Ingenuity Pathway Analysis(IPA).Results:There was a strong effect of over-feeding energy on DEG with 2434(False discovery rate-corrected P<0.05)between OVR and CTR at−14 d,and only 340 and 538 at 1 and 14 *** most-impacted and activated pathways in the Kyoto Encyclopedia of Genes and Genomes(KEGG)database that were highlighted by DIA analysis at−14 d in OVR *** included 9 associated with carbohydrate metabolism,with‘Pyruvate metabolism’,‘Glycolysis/gluconeogenesis’,and‘Pentose phosphate pathway’among the *** surprisingly,OVR led to marked activation of lipid metabolism(e.g.‘Fatty acid biosynthesis’and‘Glycerolipid metabolism’).Unexpected metabolic pathways that were activated at−14 d in OVR included several related to metabolism of amino acids(*** chain)and of cofactors and vitamins(thiamin).Among endocrine and immune system pathways,at−14 d OVR led to marked activation of‘PPAR signalling’and‘Antigen processing and presentation’.Among key pathways affected over time in OVR,a number were related to translation(*** signaling),endocrine/immune signaling(CXCR4 and IGF1),and lipid metabolism(oxidative

关键词： Periparturient cow Prepartum overfeeding subcutaneous adipose tissue Transcriptome

A comparative study on the tolerance of tilapia(Oreochromis niloticus)to high carbohydrate and high lipid diets

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Animal Nutrition 2023年第2期13卷 160-172页

作者： Lijun Ning Haotian Zhang Xiaoying Chen Jia Zhen Sen Chen Junfeng Guang Chao Xu Yuanyou Li University Joint Laboratory of Guangdong Province Hong Kong and Macao Region on Marine Bioresource Conservation and ExploitationCollege of Marine SciencesSouth China Agricultural University&Maoming BranchGuangdong Laboratory for Lingnan Modern AgricultureGuangzhou 510642GuangdongChina Laboratory of Aquatic Sciences Key Laboratory of Animal Nutrition and Feed Science in South China of Ministry of Agriculture and Rural AffairsGuangdong Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640China

A 12-wk trial was conducted to compare the tolerance of tilapia to high carbohydrate and high lipid *** isonitrogenous and isoenergetic diets,whose carbohydrate and lipid levels were the following:35.0%and 8%(control),44.2%and 4%(D1,high carbohydrate),and 25.8%and 12%(D2,high lipid),*** hundred tilapias(27±0.11 g)were fed the diets for 10 wk(4 replicates per group);72 fish from the D1 group were continually fed the D1(D1D1)and 72 fish from the D2 were continually fed the D2(D2D2)diet for 2 wk(3 replicates each group)to evaluate the tilapia's capacity to tolerate high carbohydrate and high lipid diets,*** 36 fish from D1 group were continually fed D2(D1D2)for comparison with D1D1 and D2D2 *** phase 1,hepatosomatic index,liver triglycerides(TG),glucose tolerance(GT)and crude protein in the whole body in D1 group were higher than those in D2 group(Psubcutaneous adipose tissue(SCAT)and liver TG than those in D1D1 group(P<0.05).The mRNA expression of brain npy,hepatic nrf2,gst1 and hepatic transcriptomic data showed that immune-related genes(gama,mrc2,mhc2 and cd163),were downregulated in D1D1 group compared to D2D2 and D1D2 *** together:1)tilapia have higher tolerance to a high lipid diet than high carbohydrate diet;2)despite retention of glucose tolerance,the continuous feeding of D1 diet impaired tilapia's appetite,weight gain rate and host immune response;3)specific distri-bution of fat in intraperitoneal regions,SCAT and liver may be a risk-avoidance strategy in tilapia in response to a continuous D2 diet.

关键词： Keywords:Carbohydrate and lipid Tilapia Glucose tolerance subcutaneous adipose tissue

Preoperative Assessment of Abdominal adipose tissue to Predict Microvascular Invasion in Small Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 184-189页

作者： Zongqian Wu Hong Lu Qiao Xie Jie Cheng Kuansheng Ma Xiaofei Hu Liang Tan Huarong Zhang Chen Liu Xiaoming Li Ping Cai Department of Radiology Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Department of Hepatobiliary Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Department of Neurosurgery Southwest HospitalThird Military Medical University(Army Military Medi-cal University)ChongqingChina Department of Electrical and Computer Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina Institute of Pathology and Southwest Cancer Center Third Military Medical University(Army Military Medical University)ChongqingChina

Background and Aims:Microvascular invasion(MVI)affects recurrence after treatment of small hepatocellular carcinoma(sHCC)of≤3 cm in *** present study aimed to investigate whether abdominal subcutaneous adipose tissue(SAT),visceral adipose tissue(VAT),and intermuscular adipose tissue(IMAT)are associated with MVI in patients with ***:A total of 124 patients with pathologicallyconfirmed sHCC diagnosed on surgical resection at the First Hospital Affiliated to Army Military University were recruited and divided into two groups according to MVI classification criteria(i.e.,MVI-positive or MVI-negative).The SAT,VAT,and IMAT areas at the lumbar 3 vertebral level were imaged with abdominal computed tomography and measured using ImageJ *** association with MVI in sHCC was ***:Of the 124 patients with sHCC,67 were MVIpositive and 57 were *** analysis revealed a significant difference in the abdominal VAT and SAT between the MVI-positive and MVI-negative groups(p<0.05),with an area under the receiver operating characteristic curve of 0.76 and 0.65,***:The results of this study suggest that the areas of abdominal SAT and VAT are of significant clinical value because they can effectively predict the MVI status in patients with sHCC.

关键词： Hepatocellular carcinoma subcutaneous adipose tissue Visceral adipose tissue Computed tomography

Determinants of Regional Obesity (Visceral and subcutaneous Obesity) within Cardiovascular Risk Factors in the Cardiology Department of the University Clinics of Kinshasa

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World Journal of Cardiovascular Diseases 2022年第9期12卷 444-456页

作者： Fabien Kintoki Mbala Junior Mabidi Mbangi Aliocha Natuhoyila Nkodila Jean-Robert Makulo Risassi Pascal Bayauli Eleuther Kintoki Vita Benjamin Longo-Mbenza Raoul Gombet Christian Kisoka Lusunsi Faculty of Medicine University of Kinshasa Kinshasa DR Congo Cardiology Unit Department of Internal Medicine University Clinics of Kinshasa Kinshasa DR Congo Department of Family Medicine and Primary Health Care Protestant University in Congo Kinshasa DR Congo Nephrology Unit Department of Internal Medicine University Clinics of Kinshasa University of Kinshasa Kinshasa DR Congo Cardiometabolic Unit Department of Internal Medicine University Clinics of Kinshasa University of Kinshasa Kinshasa DR Congo Walter Sisulu University Mthatha South Africa Marien Ngouabi University Brazzaville Republic of Congo Department of Public Health Lomo University of Research Kinshasa DR Congo

Objective: This study aimed to determine searching for the determinants of regional obesity (visceral and subcutaneous obesity) within the cardiovascular risk factors (CVRF) in patients followed in cardiology at the University Clinics of Kinshasa (UCK) in the Democratic Republic of Congo (DRC). Material and Methods: Cross-sectional and analytical study had sought the determinants of regional obesity (visceral and subcutaneous obesity) by bio-impedance inside the CVRF during the period from July 1 to September 31, 2014. The multivariate analysis (logistic regression) has established the levels of association between regional obesity and CVRF. The statistical significance threshold was set at p Results: A total of 642 patients participated in the present study. The frequencies of visceral and subcutaneous obesity were respectively 45.5% (without significant distinction between the two sexes: Men 48% n = 92/188 vs. Women 44.1 n = 200/454;p = 0.148) and 60.7% with a predominance in women (36.2 n = 68/188 vs. 70.9% n = 322/454;p that alongside regional obesity was: advanced age, tobacco use, alcohol use, physical inactivity, high blood pressure (HBP), diabetes mellitus (DM) and Chronic renal failure (CRF) in the respective proportions of 50.8%, 13.4%, 44.2%, 86.3%, 10.7%, 13.4% and 0.3%. The determinants of regional obesity were advanced age, smoking and obesity on body mass index (BMI) for visceral obesity;advanced age, female gender, alcohol intake and obesity on BMI and waist circumference (WC) as well as hypertriglyceridemia for subcutaneous obesity. Conclusion: This study showed a significant frequency of regional obesity with the following determinants: advanced age, female gender, smoking, alcohol, BMI/WC obesity and hypertriglyceridemia.

关键词： Regional Visceral subcutaneous adipose tissue Bio-Impedance Determinant CVRF DRC

adipose stromal/stem cells in regenerative medicine:Potentials and limitations

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World Journal of Stem Cells 2020年第1期12卷 1-7页

作者： Leandra Santos Baptista Multidisciplinary Center for Biological Research (Numpex-Bio) Federal University of Rio de Janeiro (UFRJ) Campus Duque de Caxias Post-graduate Program in Biotechnology National Institute of MetrologyQuality and Technology (INMETRO) Post-graduate Program in Translational Biomedicine (Biotrans) UnigranrioCampus Ⅰ Laboratory of tissue Bioengineering Directory of Metrology Applied to Life SciencesNational Institute of MetrologyQuality and Technology(INMETRO)

This article presents the stem and progenitor cells from subcutaneous adipose tissue,briefly comparing them with their bone marrow counterparts,and discussing their potential for use in regenerative *** adipose tissue differs from other mesenchymal stromal/stem cells(MSCs)sources in that it contains a pre-adipocyte population that dwells in the adventitia of robust blood ***-adipocytes are present both in the stromal-vascular fraction(SVF;freshly isolated cells)and in the adherent fraction of adipose stromal/stem cells(ASCs;in vitro expanded cells),and have an active role on the chronic inflammation environment established in obesity,likely due their monocyticmacrophage lineage *** SVF and ASCs have been explored in cell therapy protocols with relative success,given their paracrine and immunomodulatory ***,the widely explored multipotentiality of ASCs has direct application in bone,cartilage and adipose tissue *** aim of this editorial is to reinforce the peculiarities of the stem and progenitor cells from subcutaneous adipose tissue,revealing the spheroids as a recently described biotechnological tool for cell therapy and tissue *** cell culture techniques,in particular 3D scaffold-free cultures such as spheroids,are now available to increase the potential for regeneration and differentiation of mesenchymal *** are being explored not only as a model for cell differentiation,but also as powerful 3D cell culture tools to maintain the stemness and expand the regenerative and differentiation capacities of mesenchymal cell lineages.

关键词： Mesenchymal stromal/stem cells subcutaneous adipose tissue Stromalvascular fraction adipose stromal/stem cells Regenerative medicine Cell therapy tissue engineering Spheroids