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subconjunctival conbercept for the treatment of corneal neovascularization

International Journal of Ophthalmology(English edition) 2023年第6期16卷 871-875页

作者： Cun Sun Fang Ruan Shang Li Jian-Qiang Zhang Ying Jie Department of Ophthalmology Beijing Huimin HospitalBeijing 100053China Department of Ophthalmology Beijing You’an HospitalCapital Medical UniversityBeijing 100054China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LabBeijing 100730China

·AIM:To investigate the effectiveness and safety of subconjunctival injection of conbercept in the treatment of corneal neovascularization(CNV).·METHODS:The data on 10 consecutively recruited patients with CNV who received a subconjunctival conbercept(1 mg)once,and measured the area,length,and diameter of neovascularization before and after(1d,1,2wk,and 1mo)treatment as well as the occurrence of systemic and ocular complications after treatment were analyzed.·RESULTS:There was a statistically significant reduction in the area of CNV one day after treatment(mean±SD:38.46±11.36 mm^(2)),compared with before treatment(42.46±12.80 mm^(2),Psubconjunctival injection of conbercept is an effective and safe method for the reduction of CNV.It may be effective as a preoperative drug for neovascular corneal transplantation.

关键词： KEYWORDS:corneal neovascularization conbercept anti-vascular endothelial growth factor subconjunctival injection

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subconjunctival injections of triamcinolone acetonide to treat uveitic macular edema

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1087-1091页

作者： Yi Qu Xin-Shu Liu An-Yi Liang Jun-Yan Xiao Chan Zhao Fei Gao Mei-Fen Zhang Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College100730BeijingChina Department of Ophthalmology the Fourth People’s Hospital of ShenyangShenyang 110031Liaoning ProvinceChina Key Laboratory of Ocular Fundus Diseases Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

AIM:To evaluate the efficacy and safety of subconjunctival triamcinolone acetonide(TA)injections for treating uveitic macular edema(UME).METHODS:This retrospective case series study included patients with UME who received subconjunctival TA injections with a minimum follow-up period of 6 mo.The main outcome measure was central macular thickness(CMT).The secondary outcome measures included best-corrected visual acuity(BCVA),recurrence rate and intraocular pressure(IOP).RESULTS:In total,65 patients(80 eyes),mainly including idiopathic uveitis in 33 patients(50.77%)and VogtKoyanagi-Harada(VKH)syndrome in 19 patients(29.23%),were enrolled in this study.The mean CMT decreased from 457.6±173.0μm at baseline to 325.9±176.8,302.7±148.2,332.2±177.3 and 270.6±121.6μm at 1-,2-,3-and 6-months postinjection,respectively(all Pinjection visits,respectively(all Psubconjunctival TA deposit.CONCLUSION:subconjunctival TA injections appear to be safe and effective for UME.

关键词： triamcinolone acetonide subconjunctival injection uveitis macular edema intraocular pressure

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Comparison of subconjunctivally injected bevacizumab, ranibizumab, and pegaptanib for inhibition of corneal neovascularization in a rat model

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International Journal of Ophthalmology(English edition) 2013年第2期6卷 136-140页

作者： Ebru Eren Akar Veysi ner Cem Küükerdnmez Yonca Aydin Akova Department of Ophthalmology Artvin State Hospital Department of Ophthalmology Recep Tayyip Erdogan University Medical School Department of Ophthalmology Izmir University Medical School Kavaklidere Bayindir Hospital

AIM: To compare the efficacies of subconjunctival bevacizumab, ranibizumab, and pegaptanib sodium injections for the inhibition of corneal neovascularization in an experimental rat model. METHODS: Sixteen corneas of 16 rats were chemically cauterized and randomized into four groups: bevacizumab group that treated with 0.05mL/1.25mg bevacizumab, ranibizumab group that treated with 0.05mL/0.5mg ranibizumab, pegaptanib group that treated with 0.05mL/0.15mg pegaptanib sodium, and control group that treated with 0.05mL saline solution. Digital photographs of the corneas were taken and analyzed using an image analysis software program. All corneas were excised and examined histologically on the 15 th day. RESULTS: Each treatment group had significantly less neovascularized corneal areas and fewer blood vessels than the control group (all P 0.05). CONCLUSION: subconjunctival bevacizumab, ranibiz-umab, and pegaptanib sodium were effective with no corneal epitheliopathy for inhibiting corneal neovascularization after corneal burn in rats .Bevacizumab was more effective than ranibizumab and pegaptanib sodium.

关键词： corneal neovascularization bevacizumab ranibizumab pegaptanib subconjunctival injection

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