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Basic fibroblast growth factor attenuates the degeneration of injured spinal cord motor endplates

Neural Regeneration Research 2013年第24期8卷 2213-2224页

作者： Jianlong Wang Jianfeng Sun Yongxiang Tang Gangwen Guo Xiaozhe Zhou Yanliang Chen Minren Shen Department of Orthopedics Third Xiangya Hospital of Central South University Department of Orthopedics Yichang Central People's Hospital Department of Nuclear Medicine Xiangya Hospital of Central South University

The distal end of the spinal cord and neuromuscular junction may develop secondary degeneration and damage following spinal cord injury because of the loss of neural connections. In this study, a rat model of spinal cord injury, established using a modified Allen＇s method, was injected with basic fibroblast growth factor solution via subarachnoid catheter. After injection, rats with spinal cord injury displayed higher scores on the Basso, Beattie and Bresnahan locomotor scale. Motor function was also well recovered and hematoxylin-eosin staining showed that spinal glial scar hyperplasia was not apparent. Additionally, anterior tibial muscle fibers slowly, but progressively, atrophied. Immu- nohistochemical staining showed that the absorbance values of calcitonin gene related peptide and acetylcholinesterase in anterior tibial muscle and spinal cord were similar, and injection of basic fi- broblast growth factor increased this absorbance. Results showed that after spinal cord injury, the distal motor neurons and motor endplate degenerated. Changes in calcitonin gene related peptide and acetylcholinesterase in the spinal cord anterior horn motor neurons and motor endplate then occurred that were consistent with this regeneration. Our findings indicate that basic fibroblast growth factor can protect the endplate through gene related peptide and acetylcholinesterase cord. attenuating the decreased expression of calcitonin n anterior horn motor neurons of the injured spinal

关键词： neural regeneration spinal cord injury motor endplate basic fibroblast growth factor calcJtonJngene related peptide acetylcholinesterase subarachnoid catheter grants-supported paper neu-roregeneration

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