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A Model of subarachnoid cavity Drugs Perfusion and ItsClinical Application in Treatment of Spinal Cord Injury

Journal of Huazhong University of Science and Technology(Medical Sciences) 1997年第2期17卷 102-105页

作者：杜靖远夏志道涂意辉汪岚 Department of Orthopedics Xiehe Hospital Tongji Medical University Wuhan

An animal model of subarachnoid cavity drugs perfusion and its prelimilary clinical application in treatment of acute spinal cord injury (SCI) were reported.Analysis of the heart rate (HR), ECG, blood pressure (CVP, CAP ),cerebrospinal fluid (CSF) pressuer and CSF gas and pH values of lo healthy adultgoats during subarachnoid daxamethasone, verapamil perfusion showed that thismodel was safe and reliable. 26 patients with acute SCl were selected for a clinicalobseration. Good results were obtained in 7 cases who received this treatment of subarachnoid cavity perfusion with dexamethasone and verapamil.

关键词： subarachnoid cavity drug perfusion spinal cord injury (SCI)

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Transplantation of erythropoietin gene-modified neural stem cells improves the repair of injured spinal cord

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Neural Regeneration Research 2015年第9期10卷 1483-1490页

作者： Min-fei Wu Shu-quan Zhang Rui Gu Jia-bei Liu Ye Li Qing-san Zhu Department of Orthopedics the Second Hospital of Jilin University Department of Orthopedics Tianjin Nankai Hospital Department of Orthopedics China-Japan Union Hospital of Jilin University

The protective effects of erythropoietin on spinal Here, the eukaryotic expression plasmid pcDNA3.1 cord injury have not been well described. human erythropoietin was transfected into rat neural stem cells cultured in vitro. A rat model of spinal cord injury was established using a free falling object. In the human erythropoietin-neural stem cells group, transfected neural stem cells were injected into the rat subarachnoid cavity, while the neural stem cells group was inject- ed with non-transfected neural stem cells. Dulbecco＇s modified Eagle＇s medium/F12 medium was injected into the rats in the spinal cord injury group as a control. At 1-4 weeks post injury, the motor function in the rat lower limbs was best in the human erythropoietin-neural stem ceils group, followed by the neural stem cells group, and lastly the spinal cord injury group. At 72 hours, compared with the spinal cord injury group, the apoptotic index and Caspase-3 gene and protein expressions were apparently decreased, and the bd-2 gene and protein expressions were noticeably increased, in the tissues surrounding the injured region in the human erythro- poietin-neural stem cells group. At 4 weeks, the somatosensory evoked potential latencies were cavities were clearly smaller and the motor and remarkably shorter in the human erythropoi- etin-neural stem cells group and neural stem cells group than those in the spinal cord injury group. These differences were particularly obvious in the human erythropoietin-neural stem cells group. More CM-Dil-positive cells and horseradish peroxidase-positive nerve fibers and larger amplitude motor and somatosensory evoked potentials were found in the human erythro- poietin-neural stem cells group and neural stem cells group than in the spinal cord injury group. Again, these differences were particularly obvious in the human erythropoietin-neural stem cells group. These data indicate that transplantation of erythropoietin gene-modified neural stem cells into the subarachnoid cavity to help repair spinal cord inj

关键词： nerve regeneration spinal cord injury neural stem cells erythropoietin motor function subarachnoid cavity transplantation injury recovery neural regeneration

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Effect of Intra-arachnoid Space Perfusion on Thromboxane A and Prostacycline in Experimental Spinal Cord Injury

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Journal of Huazhong University of Science and Technology(Medical Sciences) 1997年第1期17卷 40-43,53页

作者：涂意辉杜靖远夏志道汪岚 Department of Orthopedics Xiehe Hospital Tongji Medical University Wuhan

In order to understand the relation between TXA2- PGI2 and secondary trauma and the effect of intra-arachnoid perfusion of dexamethasone and verapamil on alteration of TXA,-PGI, following spinal cord injury, TXB2 and 6-keto-PGFconcentration and pathological changes in injured site 1, 2, 4 and 6 h after injury were studied using a rabbit spinal cord injury model by Allen's weight drop method.

关键词： subarachnoid cavity thromboxane A prostacycline experimental spinal cord injury

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