检索结果-南通市图书馆

structure - Antimicrobial activity relationship Investigation of Some Butadiene and Chalcone Derivatives

Journal of Life Sciences 2013年第7期7卷 705-711页

作者： Hanoy AL-Amood Hadeel T.AL-Hadithi Ghazwan F. Fadhil Dept. of Chemistry College of Science University of Basrah Basrah 61001 Iraq Dept. of Biology College of Science University of Basrah Basrah 61001 lraq Dept. of Chemistry Faculty of Science University of Duhok Duhok 1048 BD lraq

The biological activity against Staphylococcus aureus, and Eschericia coil were investigated implementing three series, the first series was l-phenyl-2-（4＇-X-phenyl）-4-（2,4-dichlorophenyl）-1,3-butadiene, where X = H, CH3, OCH3, NH2, C1, F, NO2 and COOEt; the second was 3,4-dichlorochalcone series namely 3-（3,4-dichlorophenyl）-l-（4＇-X-phenyl）-2-propen-l-one, where X = H, CH3, OCH3, NH2, CI, F, NO2 and CN; and the third one was 2,4-dichlorochalcone series namely 3-（2,4-dichlorophenyl）-l- （4＇-X-phenyl）-2-propen-l-one, where X = H, CH3, OCH3, NH2, C1, F, NO2 and COOEt. MIC, MBC and the percentage of inhibition （activity） at 20 ~tg/mL, 15 μg/mL and 10μg/mL against Eschericia coli, and at 7.5 lag/mL, 5 μg/mL and 2.5 μg/mL against Staphylococcus aureus, were determined for each compound in the three series. Highest MIC activity against E. coli and S. aureus were given by 2,4-dichlorochalcone series. Butadiene series was similar in behavior to 2,4-dichlorochalcone series in MIC activity against S. aureus. Results of MBC revealed that compounds in the three series exerted high activity against both types of bacteria. Compounds substituted with nitro or nitril exhibited higher activity than other compounds in the three series. Percentage of inhibition of halogenated compounds （4＇-C1 and 4＇-F） was almost equal in every series. Compounds with substituents （4＇-H and 4＇-CH3） showed fluctuation in activity according to the nature of each series.

关键词： structure activity relationship chalcone butadiene, Eschericia coli Staphylococcus aureus.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immunomodulatory effects and structure-activity relationship of botanical pentacyclic triterpenes:A review

引用

Chinese Herbal Medicines 2020年第2期12卷 118-124页

作者： Nurul Hikmah Harun Abdi Wira Septama Wan Amir Nizam Wan Ahmad Rapeah Suppian School of Health Sciences Heath CampusUniversiti Sains MalaysiaKubang Kerian 16150Malaysia School of Biomedicine Faculty of Health SciencesUniversiti Sultan Zainal AbidinKuala Nerus 21300Malaysia Research Center for Chemistry Indonesian Institute of SciencesKawasan Puspitek SerpongTangerang Selatan 15314Indonesia

Botanical pentacyclic triterpenes possessed a broad range of pharmacological activities such as antioxidant,anti-tumor,anti-microbial and anti-inflammatory *** is believed that the mechanisms involved in these bioactivities are due to the modulation of immune ***,the pharmacological validation on immunomodulatory of pentacyclic triterpenes derived from higher plants is very limited and several existence review papers related for this group of compound have not been focused for this *** this review,we have highlighted several studies on immunomodulatory potential of botanical pentacyclic triterpenes isolated from wide array of different species of medicinal plants and herbs based on various preclinical in vitro and animal *** review also attempts to discuss on bioactivities of compouns related with their structure-activity ***,the evaluation of pentacyclic triterpenes offers a great opportunity to discover adjuvants and novel therapeutic agents that presented beneficial immunomodulatory properties.

关键词： botanical immunomodulatory pentacyclic triterpenes structure activity relationship

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

structure and Anti-HIV activity of Betulinic Acid Analogues

引用

Current Medical Science 2018年第3期38卷 387-397页

作者： Qiu-xia HUANG Hong-fei CHEN Xing-rui LUO Yin-xiang ZHANG Xu YAO Xing ZHENG University of South China Hengyang 421001 China Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study Hengyang 421001 China

Firstly discovered in 1980s, human immunodeficiency virus （HIV） continues to affect more and more people. However, there is no effective drug available for the therapy of HIV infection. Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects, especially its outstanding anti-HIV activity, which has drawn the attentions of many pharmacists. Among the derivatives of betulinic acid, some compounds exhibited inhibitory activities at the nanomolar concentration, and have entered phase II clinical trials. This paper summarizes the current investigations on the anti-HIV activity of betulinic acid analogues, and provides valuable data for subsequent researches.

关键词： betulinic acid analogues HIV structural modification structure activity relationship

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A narrative review on inhibitory effects of edible mushrooms against malaria and tuberculosis-the world’s deadliest diseases

引用

Food Science and Human Wellness 2023年第4期12卷 942-958页

作者： Ashaimaa Y.Moussa Baojun Xu Department of Pharmacognosy Faculty of PharmacyAin Shams UniversityCairo 11566Egypt Food Science and Technology Program BNU-HKBU United International CollegeZhuhai 519087China

The isolated secondary metabolites from 39 edible mushrooms are reported,among which 107 compounds were active,61 demonstrated antitubercular activities with IC_(50) range of 0.2-50μg/mL and 46 manifested antimalarial effects with IC_(50) range of 0.061-36μg/*** more than 2000 strains of edible mushrooms are identified,this review shows the paucity of research in these rich organisms featuring a vital culinary ingredient worldwide.A thorough search was conducted on basidiomycetes to discuss the chemistry and biology of the isolated compounds,structure activity relationships(SAR)as well as the cytotoxicity profiles of,primarily,the active anti-plasmodial and antitubercular *** a safe cellular profile,lanostane triterpenoids were found to be the only molecules with combined activities against both *** correlations reviewed here indicated the significance of 3β-and 7α-hydroxylation in the anti-tuberculosis activity and the terminal unsaturated moiety between C-4 and C-28 in the antimalarial activity in the same terpene *** review will attract the attention of medicinal chemists,and food scientists to optimize and rationalize the use of mushrooms both as unexploited sources of novel molecules and as nutraceuticals to treat two of the deadliest infectious diseases,malaria,and tuberculosis.

关键词： Antituberculosis Antiplasmodial Macrofungi Mushrooms structure activity relationship

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of the structure of ginsenosides on the in vivo fate of their liposomes

引用

Asian Journal of Pharmaceutical Sciences 2022年第2期17卷 219-229页

作者： Chen Chen Jiaxuan Xia Hongwei Ren Anni Wang Ying Zhu Ru Zhang Zicheng Gan Jianxin Wang Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China Institute of Tropical Medicine Guangzhou University of Chinese MedicineGuangzhou 510006China Institute of Integrated Chinese and Western Medicine Fudan UniversityShanghai 200040China

To utilize themultiple functions and give full play of ginsenosides,a variety of ginsenosides with different structures were prepared into liposomes and evaluated for their effect on the stability,pharmacokinetics and tumor targeting capability of *** results showed that the position and number of glycosyl groups of ginsenosides have significant effect on the in vitro and in vivo properties of their *** pharmacokinetics of ginsenosides liposomes indicated that the C-3 sugar group of ginsenosides is beneficial to their liposomes for longer circulation in *** C-3 and C-6 glycosyls can enhance the uptake of their liposomes by 4T1 cells,and the glycosyls at C-3 position can enhance the tumor active targeting ability significantly,based on the specific binding capacity to Glut 1 expressed on the surface of 4T1 *** to the results in the study,ginsenoside Rg3 and ginsenoside Rh2 are potential for exploiting novel liposomes because of their cholesterol substitution,long blood circulation and tumor targeting *** results provide a theoretical basis for further development of ginsenoside based liposome delivery systems.

关键词： Ginsenosides Liposomes structure activity relationship Rg3 liposomes Long circulation Tumor targeting Glut 1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ordered mesoporous Sn-SBA-15 as support for Pt catalyst with enhanced performance in propane dehydrogenation

引用

Chinese Journal of Catalysis 2017年第4期38卷 726-735页

作者： Bing Li Zhenxin Xu Wei Chu Shizhong Luo Fangli Jing School of Chemical Engineering Sichuan University Chengdu 610065 Sichuan China Institut de Chimie et Procédés pour l'Energie l'Environnement et la Santé (ICPEES) UMR 7515 CNRS‐Université de Strasbourg (UdS) 25 rue Becquerel67087 Strasbourg Cedex 08 France

A series of Sn‐incorporated SBA‐15materials with high specific surface areas and highly orderedmesoporous structures were synthesized by a facile one‐pot method and used as catalyst supports.A reference sample was also prepared using a conventional impregnation *** catalystswere characterized using various methods,and their activities in propane dehydrogenation *** incorporation of Sn into the SBA‐15matrix led to strong interactions between Snspecies and the support,and these helped to maintain the oxidation states of Sn species during *** with Sn changed the interfacial properties of the Pt species and improved thefunction and effect of the Sn *** catalytic activities and stabilities of the Pt catalysts supportedon Sn‐incorporated SBA‐15were better than those of the impregnated ***,thecatalytic performance deteriorated when an excessive amount of Sn was introduced and the interactionsamong Pt,Sn species,and the support became *** Pt/0.5Sn‐SBA‐15catalyst gavethe best propene selectivity,i.e.,98.5%,with a corresponding propane conversion of about43.8%.

关键词： Propane dehydrogenation One‐pot hydrothermal synthesis Sn‐incorporated SBA‐15 Pt‐based catalyst structure activity relationship

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of MgO contents on silica supported nano-size gold catalyst for carbon monoxide total oxidation

引用

Journal of Natural Gas Chemistry 2011年第5期20卷 498-502页

作者： Huiyuan Xu Weiyi Li Shuyong Shang Chunrong Yan Department of Chemical Engineering Yibin University Yibin 644000 Sichuan China Department of Chemical Engineering Stchuan University Chengdu 610065 Sichuan China

A series of nano-size gold catalysts were prepared by deposition-precipitation method using silica material promoted with different amounts of MgO as the carrier. The influences of MgO addition on the structure and property of the nano-size gold catalysts were characterized by X-ray diffraction （XRD）, transmission electron microscopy （TEM）, O2 temperature-programmed desorption （O2-TPD）, and inductively coupled with plasma atomic emission spectroscopy （ICP-AES） techniques. The total oxidation of CO was chosen as the probe reaction. The results suggest that for the gold catalysts supported on the silica material after MgO modification, the size of the gold particles is pronouncedly reduced, the oxygen mobility is enhanced, and the catalytic activity for low-temperature CO oxidation is greatly improved. The gold catalyst modified by 6 wt% MgO （Mg/SiO2 weight ratio） shows higher CO oxidation activity, over which the temperature of CO total oxidation is lower about 150 K than that over the silica directly supported gold catalyst.

关键词： new nano-size gold catalyst CO oxidation MgO SiO2 structure activity relationship

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Naphthalimides and analogues as antitumor agents:A review on molecular design, bioactivity and mechanism of action

引用

Chinese Chemical Letters 2018年第12期29卷 1741-1756页

作者： Zhuo Chen Yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologyShanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and Technology

In this review, we retrospect our progress in biological active naphthalimide and analogues as antitumor agents in the past 20 years. On one hand, various derivations in naphthalimide pharmacophores were developed to enhance their DNA binding affinity and antitumor property thereby. Heterocyclic fused naphthalimides, bis-naphthalimides, non-fused substituted naphthalimides and the carboxamide derivatives were synthesized. For example, thio-heterocyclic fused-naphthalimides were designed and evaluated in comparison with their oxo-heterocyclic fused analogues. Extended or created heterocyclebased skeleton were also developed as antitumor agents. On the other hand, we broaden the design strategy of naphthalimide antitumor agents besides DNA intercalation and topo II poison. We have introduced more drug design methods, such as prodrugs, multitarget drugs, computer-aided drug design,photodynamic therapy. For example, we have got naphthalimide derivatives which inhibited topo II and induced LMP by introducing long alkyl chain and polyamines. Several representative compounds were clarified of their antitumor mechanism of action. In all, our research improves the structure diversity of naphthalimide antitumor agents and distinct variances of antitumor targets and mechanism of action.

关键词： Naphthalimides Antitumor structure activity relationship Drug design strategy Mechanism of action

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis, Insecticidal Activities and Molecular Docking Studies on cis-Nitenpyram Analogues with a Flexible Amido Segment Anchored on Tetrahydropyrimidine Ring

引用

Chemical Research in Chinese Universities 2014年第6期30卷 931-936页

作者： FANG Ting SUN Chuanwen XU Yiyi YUAN Jing WANG Yuanfeng XING Jiahua College of Lzfe and Environment Sciences Shanghai Normal University Shanghai 200234 P. R. China Bioassay Department Branch of National Pesticide R&D South Center Hangzhou 310023 P R. China Patent Examination Cooperation Jiangsu Center of the Patent Office SIPO Suzhou 215011 P R. China

To make further studies on the difference of cis-nitenpyram analogues, a series of cis-nitenpyram com- pounds containing a flexible amido segment anchored on tetrahydropyrimidine ring was designed and synthesized. Preliminary bioassays indicate that all the analogues exhibit a mortality of 100% at 100 rag/L, and the analogue 4d shows the best activity against Nilaparvata lugens and Myzus persicae, with a mortality of 100% at 4 mg/L （LCs0=0.172 rag/L）. The structure activity relationship studies show that insecticidal activities of the analogues are affected by the kinds and size of substituent R. In addition, the molecular docking simulations reveal that compouds 4 with a flexible amido segment on tetrahydropyrimidine ring show their different binding affinities for the nicotinic acetyleholine receptor（nAChR） of insect and compoud 4d shows stronger hydrogen-bonding with nAChR, which may provide the structure-activity relationship observed in vitro.

关键词： cis-Nitenpyram analogue Nicotinic acetylcholine receptor(nAChR) Flexible amido segment Hydro-gen-bonding action structure activity relationship Insecticidal activity Molecular docking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis of Trihydrocarbyltin Chloride Containing Silicon and Crystal structure of (p-Cl-C_6H_4Me_2SiCH_2)_3SnCl

引用

Chemical Research in Chinese Universities 2002年第3期18卷 277-279页

作者： ZHONG Gui yun LIU Hua XIE Qing lan Institute of Elemento organic Chemistry Nankai UniversityTianjin 300071P.R.China

A series of trihydrocarbyltin chlorides containing silicon was synthesized. The acaricidal activity was determined and the structure activity relationship was tried to be found out with the hydrophobic parameter.

关键词： Organotin and organosilicon Acaricidal activity structure activity relationship

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：