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structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride

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Protein & Cell 2016年第4期7卷 300-304页

作者： Linlin Zhao Shuqing Wang Lingyu Du Jyoti Dev Liujuan Zhou Zhijun Liu James J. Chou Bo OuYang National Center for Protein Science State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai 200031 China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics) School of Pharmacy Tianjin Medical University Tianjin 300070 China Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA 02115 USA Shanghai Science Research Center Chinese Academy of Sciences. Shanahai 201204. China

Dear Editor, Hepatitis C virus （HCV） infection, which causes hepatitis C and can chronically lead to serious and life-threatening dis- eases including liver cirrhosis and hepatocellular carcinoma （Lauer and Walker, 2001）, is a rising global health problem. More than 170 million people are infected by HCV worldwide and 3-4 million people are infected each year. No effective vaccines are available to prevent HCV infection. Moreover, HCV is a fast mutating RNA virus with seven distinct genotypes and many subtypes within each genotype. The high degree of genetic diversity can lead to further viral resistance to the current therapies within individual patients （Li et al., 2012）. Hence, there remains a strong desire in the medical community to explore new therapeutic opportunities.

关键词： structural basis interaction between

Oligomerization of drug transporters:Forms,functions,and mechanisms

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1924-1938页

作者： Chunxu Ni Mei Hong College of Life Sciences South China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms South China Agricultural UniversityGuangzhou 510642China

Drug transporters are essential players in the transmembrane transport of a wide variety of clinical *** broad substrate spectra and versatile distribution pattern of these membrane proteins infer their pharmacological and clinical *** our accumulating knowledge on the three-dimensional structure of drug transporters,their oligomerization status has become a topic of intense study due to the possible functional roles carried out by such kind of post-translational modification(PTM).In-depth studies of oligomeric complexes formed among drug transporters as well as their interactions with other regulatory proteins can help us better understand the regulatory mechanisms of these membrane proteins,provide clues for the development of novel drugs,and improve the therapeutic *** this review,we describe different oligomerization forms as well as their structural basis of major drug transporters in the ATP-binding cassette and solute carrier superfamilies,summarize our current knowledge on the influence of oligomerization for protein expression level and transport function of these membrane proteins,and discuss the regulatory mechanisms of ***,we highlight the challenges associated with the current oligomerization studies and propose some thoughts on the pharmaceutical application of this important drug transporter PTM.

关键词： Drug development Drug transporters Oligomerization Protein expression Protein–protein interaction Regulatory mechanism structural basis Transport function

High-resolution 3D Structures Reveal the Biological Functions of Reoviruses

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维普期刊数据库

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Virologica Sinica 2013年第6期28卷 318-325页

作者： Xiaoming Li Qin Fang State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of Sciences School of Basic Medical Sciences Wuhan University

Viruses in the family Reoviridae are non-enveloped particles comprising a segmented double-stranded RNA genome surrounded by a two-layered or multi-layered icosahedral protein *** viruses are classified into two sub-families based on their particle structural *** studies have focused on high-resolution three-dimensional structures of reovirus particles by using cryo-electron microscopy (cryo-EM) to approach the resolutions seen in X-ray crystallographic *** results of cryo-EM image reconstructions allow tracing of most of the protein side chains,and thus permit integration of structural and functional information into a coherent mechanism for reovirus assembly and entry.

关键词： Non-enveloped virus Reoviruses structural basis Assembly Cell entry

The Research of Ecological Nutritional Organs of Invasive Plants structural Characteristics

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Agricultural Science & Technology 2011年第6期12卷 812-814页

作者：魏健盖玉红蔡立格曲红岩王英伟王光野长春师范学院生命科学学院吉林长春130032 吉林农业大学农学院吉林长春130118 吉林省实验中学吉林长春130022 东北师范大学生命科学学院吉林长春130024 吉林省梅河口市博文学校吉林梅河口135000

[Objective] The aim of this paper was to discuss the adaptability of ecological nutritional organs of invasive plants.[Method] By dint of high-definition display of plant tissue crystal method and paraffin section method,the vegetative organs root,stem and leaf cross-section of the organizational structure of Asteraceae Ambrosia trifida ***（Ambrosia trifida L.）in the suburbs of Changchun City in Jilin Province were inspected.[Result] The structural basis for ecological invasive plant Ambrosia trifida *** organs was mainly through strengthening the roots of water absorption and transporting function,increasing the water storage function of leaf and stem,reducing the water absorption of stem and leaf for plants to promote water absorption and to enhance the assimilation of leaves to achieve a variety of complex environmental conditions in the rapid growth and development in order to achieve an ecological invasion.[Conclusion] The study provided reference for the biological fundamental research of Ambrosia trifida L.

关键词： Ambrosia trifida L.(Ambrosia trifida L.) Crystal Ecological invasion structural basis

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民办高校高质量发展的基础