检索结果-南通市图书馆

Prediction model of stress ulcer after laparoscopic surgery for colorectal cancer established by machine learning algorithm

引用

世界胃肠外科杂志:英文版(电子版) 2023年第9期15卷 1978-1985页

作者： Dong-Mei Yu Chun-Xiao Wu Jun-Yi Sun Hui Xue Zhe Yuwen Jiang-Xue Feng School of Nursing Hebei University of Traditional Chinese MedicineShijiazhuang 050000Hebei ProvinceChina Department I of Anorectal Hebei Traditional Chinese Medicine HospitalShijiazhuang 050000Hebei ProvinceChina Department of Inspection Center Hebei Traditional Chinese Medicine HospitalShijiazhuang 050000Hebei ProvinceChina Department of Perivascular Hebei Traditional Chinese Medicine HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Patients with colorectal cancer(CRC)are prone to stress ulcer after laparoscopic *** analysis of risk factors for stress ulcer(SU)in patients with CRC is important to reduce mortality and improve patient *** To identify risk factors for SU after laparoscopic surgery for CRC,and develop a nomogram model to predict the risk of SU in these *** The clinical data of 135 patients with CRC who underwent laparoscopic surgery between November 2021 and June 2022 were reviewed *** were divided into two categories depending on the presence of SUs:The SU group(n=23)and the non-SU group(n=112).Univariate analysis and multivariate logistic regression analysis were used to screen for factors associated with postoperative SU in patients undergoing laparoscopic surgery,and a risk factor-based nomogram model was built based on these risk *** plotting the model's receiver operating characteristic(ROC)curve and calibration curve,a Hosmer-Lemeshow goodness of fit test was *** Among the 135 patients with CRC,23 patients had postoperative SU,with an incidence of 17.04%.The SU group had higher levels of heat shock protein(HSP)70,HSP90,and gastrin(GAS)than the non-SU ***,lymph node metastasis,HSP70,HSP90,and GAS levels were statistically different between the two groups,but other indicators were not statistically *** regression analysis showed that age≥65 years,lymph node metastasis,and increased levels of HSP70,HSP90 and GAS were all risk factors for postoperative SU in patients with CRC(P<0.05).According to these five risk factors,the area under the ROC curve for the nomogram model was 0.988(95%CI:0.971-1.0);the calibration curve demonstrated excellent agreement between predicted and actual probabilities,and the Hosmer-Lemeshow goodness of fit test revealed that the difference was not statistically significant(χ2=0.753,P=0.999),suggesting that the nomogram model had good discrimination,cali

关键词： Colorectal cancer Laparoscope stress ulcer Risk factors Nomogram

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect and Mechanism of Moxibustion on Acupoints Zusanli （ST 36） and Liangmen （ST 21） in the Prevention and Treatment of stress ulcer

引用

Journal of Acupuncture and Tuina Science 2007年第1期5卷 14-20页

作者：彭艳易受乡常小荣彭娜严洁林亚平朱忠春(Translator) Hu'nan College of Traditional Chinese Medicine Changsha 41000 P. R. China 不详

Objective： To observe the effect of moxibustion on acupoints Zusanli （ST 36） and Liangmen （ST 31） on cell proliferation and cell apoptosis of gastric mucosa in rats with stress ulcer, investigatethe mechanism of moxibustion in promoting the repair of gastric mucosal injury at cellular and molecular levels, Methods： Sixty healthy Sprague-Dawley rats were randomly divided into four groups： the restraint control group, model group, moxibustion on acupoints group and moxibustion on non-acupoints group. Water immersion and restraint stress （WRS） was used to copy the stress ulcer model of rats, radio-immunoassay was used to detect the content of transforming growth factor （TGF-α）, and S-P immunohistochemical assay was adopted to determine the HSP70 expression, the proliferating cell nuclear antigen （PCNA） and cell apoptosis index in gastric mucosa. Results： For the WRS-induced gastric ulcer model of rat, the gastric mucosal injury （gastric ulcer index, UI） was increased, the content of TGF-α was decreased, PCNA was also decreased, HSP70 expression and cell apoptosis index were all increased （P〈0.01）, Moxibustion on acupoints Zusanli （ST 36） and Liangmen （ST 31） could decrease UI, increase the content of TGF-α, promote the expression of PCNA and HSP70, decrease cell apoptosis index in gastric mucosa, with significant differences when compared with the model group and control group （P〈0.01）. Conclusions： Moxibustion on acupoints Zusanli （ST 36） and Liangmen （ST 31） had protective effect on the gastric mucosa of stress ulcer, its mechanism may be promoting the TGF-α synthesis, stimulating cell proliferation in gastric mucosa and inhibiting cell apoptosis in gastric mucosa, and this process is related to the moxibustion-induced HSP70 expression.

关键词： Moxibustion Therapy stress ulcer HSP70 Cell Apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of astragaloside on gastric mucosa of stress ulcer rats

Influence of astragaloside on gastric mucosa of stress ulcer...

引用

两岸三地药理学与临床药理学术会议

作者： LI Yan-wu (Institute of PiWei, Guangzhou University of Chinese medicine, Guangzhou 510405, China)

Objective To investigate the effect of astragaloside (AST) on the gastric mucosal injury of water immersion restraint stress ulcer *** The stress ulcer model was made by water immersion and re- *** gastric mucosal injury index was *** SOD activity,the MDA contents and the gene expression of melatonin receptor 1 and 2 were detected in gastric *** Compared with the normal group,the model group showed mucous edema,hyperemia and even ulcer *** injury index and the MDA content of gastric mucosa in model group were significantly increased (Pulcer index and MDA con- tents relieved obviously (Pstress *** the mechanism of the gastric mucosal protection should be concerned with regulat- ing the melatonin receptor and lessening the injury of oxygen free radical.

关键词： astragaloside oxygen free radical melatonin receptor stress ulcer

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Investigation of the correlation between MODS score and incidence of stress ulcer

Investigation of the correlation between MODS score and inci...

引用

第七次全国中毒与危重症救治学术年会、第二届宝安急危重症高峰论坛、国家级继续项目“心肺复苏与急危重症学习班”

作者： LIN Jin-feng YANG Zhi-zhou Shinan Nie Jingling Hosp Dept EmergencyNanjing UnivSch Med

BACKGROUND:To predict the incidence of stress ulcer among multiple organ dysfunction syndrome（MODS）patients,which can provide basis for ***:Clinical data of two hundred and sixty-two patients who conform to the MODS diagnosis criterionadmitted to our EICU from August 2008 to August 2012 was investigated in the retrospective *** MODS patients were evaluated with MODS score criterion of *** to the diagnosis criterion of stress ulcer,the stress ulcer was *** between the score with incidence of stress ulcer was studied by rank *** ability of MODS score to predict the incidence of stress ulcer was estimated with *** critical value was obtained by Youden *** Correlation coefficient was 0.693（Pstress ulcer was ***:The incidences of stress ulcer can be predicted by MODS score to some *** ulcer prophylaxis is necessary when the MODS score is above 9.

关键词： stress ulcer multiple organ dysfunction syndrome severity score correlation prophylaxis intensive care unit retrospective study incidence

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Dynamic functional and ultrastructural changes of gastric parietal cells induced by water immersion-restraint stress in rats

引用

World Journal of Gastroenterology 2006年第21期12卷 3368-3372页

作者： Yu-Mei Li Guo-Ming Lu Xiao-Ping Zou Zhao-Shen Li Gui-Yong Peng Dian-Chun Fang Department of Gastroenterology Hospital of Zhejiang Armed Police Forces Crops Jiaxin 314000 Zhejiang Province China Department of Pathology Medical College Jiaxing University Jiaxing 314000 Zhejiang Province China Department of Gastroenterology of Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Gastro- enterology of Southwest Hospital Third Military Medical University Chongqing 400038 China

AIM： To investigate the dynamic functional and ultrastructural changes of gastric parietal cells induced by water immersion-restraint stress （WRS） in ***： WRS model of Sprague-Dawley （SD） rats was established. Fifty-six male SD rats were randomly divided into control group, stress group and post-stress group. The stress group was divided into 1, 2 and 4 h stress subgroups. The post-stress group was divided into 24, 48 and 72 h subgroups. The pH value of gastric juice, ulcer index （UI） of gastric mucosa and H^＋, K^＋- ATPase activity of gastric parietal cells were measured. Ultrastructural change of parietal cells was observed under transmission electron microscope （TEM）.RESULTS： The pH value of gastric juice decreased time-dependently in stress group and increased in post-stress group. The H^＋, K^＋-ATPase activity of gastric parietal cells and the UI of gastric mucosa increased time-dependently in stress group and decreased in poststress group. Compared to control group, the pH value decreased remarkably （P = 0.0001）, the UI and H^＋, K^＋- ATPase activity increased significantly （P = 0.0001, P = 0.0174） in 4 h stress subgroup. UI was positively related with stress time （r = 0.9876, P 〈 0.01） but negatively with pH value （r = -0.8724, P 〈 0.05）. The parietal cells became active in stress group, especially in 4 h stress subgroup, in which plenty of intracellular canalicular and mitochondria were observed under TEM. In post-stress group, the parietal cells recovered to resting ***： The acid secretion of parietal cells is consistent with their ultrastructural changes during the development and healing of stress ulcer induced by WRS and the degree of gastric mucosal lesions, suggesting gastric acid play an important role in the development of stress ulcer and is closely related with the recovery of gastric mucosal lesions induced by WRS.

关键词： stress ulcer Gastric parietal cells UItrastructure H^+, K^+-ATPase activity Sprague-Dawley rat

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of high expression in rat gastric mucosal heat shock protein 70 induced by moxibustion pretreatment with protection against stress injury

引用

World Journal of Gastroenterology 2007年第32期13卷 4355-4359页

作者： Xiao-Rong Chang La Peng Shou-Xiang Yi Yan Peng Jie Yan College of Acupuncture and Massage Hunan University of Traditional Chinese Medicine Changsha 410007 Hunan Province China Hunan Yi-Er-Kang Healthcare Limited Company Changsha 41001 Hunan Province China

AIM:To study the effect of moxibustion on Zusanli or Liangmeng point on gastric mucosa injury in stress-induced ulcer rats and its correlation with the expression of heat shock protein 70 (HSP70). METHODS:Sixty healthy SD rats (30 males,30 females) were divided into control group,injury model group,Zushanli point group,Liangmeng point group. stress gastric ulcer model was induced by binding cold stress method. Gastric mucosa ulcer injury (UI) index was calculated by Guth method. Gastric mucosa blood flow (GMBF) was recorded with a biological signal analyzer. Protein content and gene expression in gastric mucosal HSP70 were detected by immunohistochemistry (IHC) and reverse transcription polymerase chain reaction (RT-PCR). Thiobarbital method was used to determine malondialdehyde (MDA) content. Gastric mucosal endothelin (ET) and prostaglandin E2 (PGE2) were analyzed by radioimmunoassay. RESULTS:High gastric mucosal UI index,high HSP70 expression,low GMBF and PGF2,elevated MDA and ET were observed in gastric mucosa of rats subjected to cold stress. Moxibustion on Zusanli or Liangmeng point decreased rat gastric mucosal UI index,MDA and ET. Conversely,the expression of HSP70,GMBF,and PGE2 was elevated in gastric mucosa after pretreatment with moxibustion on Zusanli or Liangmeng point. The observed parameters were significantly different between Zusanli and Liangmeng points. CONCLUSION:Pretreatment with moxibustion on Zusanli or Liangmeng point protects gastric mucosa against stress injury. This protection is associated with the higher expression of HSP70 mRNA and protein,leading to release of PGE2 and inhibition of MDA and ET,impairment of gastric mucosal index.

关键词： Moxibustion Zusanli Liangmeng stress ulcer Gastric mucosa protection Heat shock protein70 Gastric mucosal blood flow Prostaglandin E2 Malondialdehyde Endothelin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of pre-moxibustion on apoptosis and proliferation of gastric mucosa cells

引用

World Journal of Gastroenterology 2007年第15期13卷 2174-2178页

作者： Shou-Xiang Yi Yan Peng Xiao-Rong Chang Na Peng Jie Yan Yap-Ping Lin The Institute of Acupuncture Moxibustion and Massage Hunan University of Traditional Chinese Medicine Changsha 410007 Hunan Province China

AIM： TO observe the effects of pre-moxibustion on apoptosis and proliferation of gastric mucosal cell in rats with stress-induced ulcer, and to analyze the relationship between those effects and the expression of heat-shock protein 70 （HSP70）. METHODS： Sixty healthy Sprague Dawley rats were randomly assigned into four groups, namely group A, B, C and D. The animal model of stress ulcer was established by water immersion and restraint stress. The rats in group A, B, and D served as the restraint, model, and non-acupoint controls, respectively, while those in group C received moxibustion at Zusanli and Uangmen points. Immunohistochemical methodology was used to detect the expression of HSP70, apoptosis index （AI, × 10^-6/μm^2） and proliferation index （PCNA-LI, × 10^-6/μm^2）. The mucosal expression of transforming growth factor α （TGF-α） was detected by radioimmunoassay. RESULTS： IVloxibustion at Zusanli and Liangmen points significantly decreased the gastric injury and the apoptosis of gastric mucosal cells, while markedly increased the mucosal expression of TGF-α and HSP70 as well as the proliferation of gastric mucosal cells. Compared with group A, ulcer index （UI）（26.8 ± 9.8 vs 12.0 ± 5.9, P 〈 0.01）, AI （9.6 ± 4.2 vs 4.4 ± 2.6, P 〈 0.05） and expression of HSP70 （9.6 ± 4.2 vs 4.4 ± 2.6, P 〈 0.05） were significantly increased, but the content of TGF-α （104.7 ± 51.2 pg/mL vs 254.0 ± 86.9 pg/mL, P 〈 0.01） and PCNA-LI （6.9 ± 4.7 vs 14.9 ± 4.6, P 〈 0.05） were significantly decreased in group B. However, ulcer index values （UI） and AI were obviously lower in group C compared to groups B and D （14.1 ± 5.4 vs 26.8 ± 9.8 and 26.2 ± 7.7, P 〈 0.01, 3.0 ± 1.6 vs 9.6 ± 4.2 and 8.2 ± 5.2, P 〈0.05, respectively）, but content of TGF-α （237.0 ± 72.6 pg/mL vs 104.7 ± 51.2 pg/mL and 154.1 ± 61.3 pg/mL, P 〈0.01） and expression of HSP70 （0.13 ± 0.03 vs 0.08 ± 0.06 and 0.06 ± 0.04, P 〈 0.05） were higher in group C. Furthermore, the PCNA-LI was significantly higher in group C than in

关键词： Moxibustion stress ulcer HSP70 Proliferating cell nuclear antigen Apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Curling ulcer in the setting of severe sunburn: A case report

引用

World Journal of Gastrointestinal Endoscopy 2020年第11期12卷 500-503页

作者： Alexander Schosheim Michelle Tobin Anupama Chawla Department ofPediatric Gastroenterology Stony Brook University HospitalStony BrookNY 11794United States

BACKGROUND While sunburns are very common,especially in pediatrics,curling ulcers secondary to sunburns are a very rare entity that has not been noted in the literature in over fifty *** case is the first addition to the literature since the originally documented *** SUMMARY A previously healthy 17 year old male presents to the emergency room with lethargy,shortness of breath on exertion,dark stools and *** fatigue started to become significantly worse four days prior to *** two weeks prior to admission,the patient was on a beach vacation with his family at which time he suffered severe *** had developed crampy epigastric abdominal pain,which was followed by dark,loose *** exam,he is non-toxic appearing,but with pallor and peeling skin on his face and chest with epigastric *** stool studies were all negative including Helicobacter *** denies use of any non-steroidal anti-inflammatory drugs and also denies alcohol or recreational drug *** admitted he is found to be significantly anemic with his hemoglobin as low as 6.3 requiring two units of packed red blood *** revealed several severe and deep ulcerations in the antrum and body of the stomach indicative of stress or curling *** While the incidence of stress ulcers is not known,it is most common with severe acute illness,most commonly presenting as upper gastrointestinal(GI)*** is essential to be aware of the risk of curling ulcers secondary to severe sunburns as patients with stress ulcer GI bleeding have increased morbidity and mortality compared to those who do not have GI bleed.

关键词： Curling ulcer Sunburn stress ulcer Pediatrics Gastroenterology Gastrointestinal bleed Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：