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Coupled effects of stress damage and drilling fluid on strength of hard brittle shale

Journal of Central South University 2016年第12期23卷 3256-3261页

作者：汪伟邓金根蔚宝华郑小锦闫传梁邓月 State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum

During well drilling process,original stress state of hard brittle shale will be changed due to stress redistribution and concentration,which leads to stress damage phenomenon around the ***,drilling fluid will invade into formation along the tiny cracks induced by stress damage,and then weaken the strength of hard brittle *** on this problem,a theoretical model was set up to discuss damage level of shale under uniaxial compression tests using acoustic velocity *** specifically,considering the coupled effect of stress damage and drilling fluid,the relationship between hard brittle shale strength and elapsed time was analyzed.

关键词： hard brittle shale stress damage drilling fluid time effect strength

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Prophylactic treatment with growth hormone improves intestinal barrier function and alleviates bacterial translocation in stressed rats

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Chinese Medical Journal 2004年第2期17卷 264-269页

作者：丁连安黎介寿李幼生刘放南谭力 Department of General Surgery Affiliated Hospital of Qingdao University Medical School Qingdao 266003 China Research Institute of General Surgery Nanjing University Medical School Nanjing Military Area the People ' s Liberation Army Nanjing 210002 China

Background damage to the gut barrier often occurs during critical illnesses. In such cases, it is very important to alleviate impairment of the intestinal barrier and protect intestinal barrier function. This study investigated the protective effect of growth hormone on intestinal barrier function in rats under stress.Methods This study consisted of prospective, randomized, and controlled animal experiments. Twenty-five Sprague-Dawley rats served as total parenteral nutrition (TPN) models and were divided into three groups: TPN group, sepsis (Sep) group, and growth hormone (GH) group. Another 8 rats served as normal controls. Each group received different stress stimuli. Rats were fed for 7 days, and samples were taken for examination 24 hours after gavaging with dual saccharides.Results The architecture of the small intestinal mucosa in the Sep group showed the most severe damage among all groups. Nitric oxide levels in blood plasma and immunoglobulin A levels in the intestinal mucosa of the GH group were significantly lower than in the Sep group (Pdamage to intestinal barrier function caused by trauma and endotoxemia in rats under stress.

关键词： growth hormone stress damage intestinal barrier bacterial translocation lactulose/mannitol test

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