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Polyethylene glycol 3350 in occasional constipation: A one-week, randomized, placebo-controlled, double-blind trial

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 274-282页

作者： Thomas Mc Graw Merck & Co. Inc.

AIM:to evaluate the efficacy and safety of polyethylene glycol(PEG)3350 in subjects with self-reported occasional ***:Eligible subjects≥17 years of age were randomized to receive either placebo or PEG 335017 g once daily in this multicenter,double-blind *** were conducted before(baseline)and after a 7-d treatment *** primary efficacy variable was the proportion of subjects reporting complete resolution of straining and hard or lumpy *** efficacy variables assessed the severity of the subjects’daily bowel movement(BM)symptoms,and preference of laxatives based on diary entries,visual analog scale scores,and ***:Of the 203 subjects enrolled in the study,11had major protocol *** resolution was noted by 36/98(36.7%)subjects in the PEG 3350 group and 23/94(24.5%)in the placebo group(P=0.0595).The number of complete BMs without straining or lumpy stools was similar between both *** receiving PEG 3350 experienced significant relief in straining and reduction in hardness of stools over a7-d period(P<0.0001).Subjects reported that PEG3350 had a better effect on their daily lives,provided better control over a BM,better relief from constipation,cramping,and bloating,and was their preferred *** events(AEs)were balanced between the PEG3350 and the placebo *** deaths,serious AEs,or discontinuations due to AEs were *** trial is registered at *** as ***:Oral administration of 17 g PEG3350 once daily for a week is effective,safe,and well tolerated in subjects with occasional constipation.

关键词： Polyethylene glycol 3350 Laxative straining Bowel movements Occasional constipation

Prospective evaluation of the hemorrhoid energy treatment for the management of bleeding internal hemorrhoids

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World Journal of Gastrointestinal Endoscopy 2021年第8期13卷 329-335页

作者： Truptesh H Kothari Krystle Bittner Shivangi Kothari Vivek Kaul Division of Gastroenterology and Hepatology University of Rochester Medical CenterRochesterNY 14642United States

BACKGROUND The hemorrhoid energy treatment(HET)system is a non-surgical bipolar electrotherapy device,which has previously demonstrated efficacy in the management of bleeding Grade I and II internal hemorrhoids;however,data is *** To prospectively assess the safety and efficacy of the HET *** This was an IRB-approved prospective study of 73 patients with Grade I or II internal hemorrhoids who underwent HET from March 2016 to June *** factors and procedural data were obtained.A post-procedure questionnaire was administered by telephone to all patients at 1-wk and 3-mo following HET to assess for improvement and/or resolution of rectal bleeding and adherence to a stool softener regimen.A chart review was performed to observe recurrent symptoms and durability of *** analyses were performed using SPSS software(IBM;SPSS Version 25.0).RESULTS Seventy-three patients underwent HET during the study *** post-HET follow-up was 1.89 *** resolution of bleeding was reported in 65%at 1 wk(n=48),with improvement in bleeding in 97.2%(n=71)of *** 3-mo,resolution and/or improvement in bleeding was reported in 90%(n=64)of *** procedure-related pain or adverse events were *** HET is well tolerated,safe and highly effective in the majority of our patients presenting with Grade I and II symptomatic internal hemorrhoids.

关键词： Internal hemorrhoids Bleeding hemorrhoids Painless bleeding Mucus Constipation straining

Different typologies of workplace conflict and their connections with post traumatic embitterment disorder (PTED)

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Health 2010年第3期2卷 234-236页

作者： Harald Ege Università Politecnica delle Marche Ancona Italy

Reported is an empirical study which shows that Post-Traumatic Embitterment Disorder (PTED) is the most appropriate psychological diagnosis for victims of workplace conflicts, particularly bullying. A group of 118 people all reporting conflict at work were evaluated with the LIPT questionnaire, the PTED self-rating scale and a guided psychological interview. 91.5% proved to be affected by a PTED, the slight majority males, aged between 31 and 40 years and subjected to bullying. The evidence suggests that some workplace conflict victims who are presently diagnosed and treated as depression or phobia can be in fact cases of PTED. The treatment may be adjusted and the PTED scale may be used as a screening in-strument similar to scales for anxiety and depressive disorders.

关键词： Workplace Conflict PTED Bullying straining

Complete rectal prolapse in young Egyptian males: Is schistosomiasis really condemned?

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World Journal of Gastrointestinal Surgery 2016年第12期8卷 779-783页

作者： Ahmed A Abou-Zeid Islam H El Abbassy Ahmed M Kamal Dina A Somaie Unit of Colorectal Surgery Department of General Surgery El Demerdash Hospital Ain Shams University

AIM To investigate the assumption that schistosomiasis is the main cause of rectal prolapse in young Egyptian males. METHODS Twenty-one male patients between ages of 18 and 50 years with complete rectal prolapse were included in the study out of a total 29 patients with rectal prolapse admitted for surgery at Colorectal Surgery Unit, Ain Shams University hospitals between the period of January 2011 and April 2014. Patients were asked to fill out a specifically designed questionnaire about duration of the prolapse, different bowel symptoms and any past or present history of schistosomiasis. Patients also underwent flexible sigmoidoscopy and four quadrant midrectal biopsies documenting any gross or microscopic rectal pathology. Data from questionnaire and pathology results were analyzed and patients were categorized according to their socioeconomic *** Twelve patients(57%) never contracted schistosomiasis and were never susceptible to the disease, nine patients(43%) had history of the disease but were properly treated. None of the patients had gross rectal polypsand none of the patients had active schistosomiasis on histopathological examination. Fifteen patients(71%) had early onset prolapse that started in childhood, majority before the age of 5 years. Thirteen patients(62%) were habitual strainers, and four of them(19%) had straining dating since early childhood. Four patients(19%) stated that prolapse followed a period of straining that ranged between 8 mo and 2 years. Nine patients(43%) in the present study came from the low social class, 10 patients(48%) came from the working class and 2 patients(9%) came from the low middle social class. CONCLUSION Schistosomiasis should not be considered the main cause of rectal prolapse among young Egyptian males. Childhood prolapse that continues through adult life is likely involved. Childhood prolapse probably results from malnutrition, recurrent parasitic infections and diarrhea that induce straining and prolaps

关键词： Rectal prolapse Schistosomiasis Young Egyptian males Low socioeconomic status Chronic straining