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stimulatory effect on the transport mediated by organic anion transporting polypeptide 2B1

Asian Journal of Pharmaceutical Sciences 2020年第2期15卷 181-191页

作者： Jiro Ogura Hiroaki Yamaguchi Nariyasu Mano Tohoku University Hospital Department of Pharmaceutical SciencesMiyagi 980-8574Japan

Drug-drug interaction(DDI)is one of causes of adverse drug events and can result in lifethreatening *** anion-transporting polypeptide(OATP)2B1 is a major uptake transporter in the intestine and contributes to transport various clinically used therapeutic *** intestine has a high risk of DDI,because it has a special propensity to be exposed to a high concentration of ***,understanding drug interaction mediated by OATP2B1 in the absorption process is important for the prevention of adverse drug events,including decrease in the therapeutic effect of co-administered *** drug interaction occurs through the direct inhibitory effect on transporters,including ***,some compounds such as clinically used drugs and food components have an acute stimulatory effect on transport of co-administered drugs by *** review summarizes the acute stimulatory effect on the transport mediated by OATP2B1 and discusses the mechanisms of the acute stimulatory effects of *** are two types of acute stimulatory effects,substrate-independent and-dependent interactions on OATP2B1 *** facilitating translocation of OATP2B1 to the plasma membrane is one of causes for the substrate-independent acute stimulatory *** the contrary,the substrate-dependent effect is based on the direct binding to the substrate-binding site or allosteric progesterone-binding site of OATP2B1.

关键词： OATP2B1 Drug interaction stimulatory effect Membrane translocation Conformational change

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Reconstitution of Gs and Adenylate Cyclase From Bovine Brain Cortices on Asolectin Liposomes

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Chinese Science Bulletin 1994年第18期39卷 1558-1562页

作者：范高峰黄有国 State Key Laboratory of Biomacromolecules Institute of Biophysics Academia Sinica Beijing 100101 PRC

Signal transduction across cell membranes is an important subject of the current studies on biomembranes. Hormonally regulated adenylate cyclase signalling system is composed of three distinct types of plasma-membrane... 详细信息

关键词： stimulatory GTP-binding protein (Gs) adenylate cyclase (AC) reconstitution bovine brain.

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Purification of β-adrenergic receptors from Beijing duck erythrocyte plasma membranes and their reconstitution with Gs and adenylate cyclase on asolectin liposomes

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Chinese Science Bulletin 1995年第24期40卷 2075-2080页

作者：范高峰杨小毅黄有国 National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

Catecholamines such as adrenaline, norepinephrine and isoproterenol regulate a wide variety of physiological responses via their specific binding to adrenergic receptors located in the plasma membrane. Adrenergic receptors have been divided into two major types, α and β. Binding of ligands to β-adrenergic receptors (β-AR) first triggers the activation of stimulatory GTP-binding protein (Gs). The activated Gs then interacts

关键词： β-adrenergic receptors (β-AR) stimulatory GTP-binding proteins (Gs) adenylate cyclase (AC) reconstitution.

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Effects of Streptomyces <i>Biofertilizer</i>to Soil Fertility and Rhizosphere’s Functional Biodiversity of Agricultural Plants

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Advances in Microbiology 2015年第7期5卷 555-571页

作者： Tinatin Doolotkeldieva Saykal Bobusheva Maxabat Konurbaeva Plant Protection Department Faculty of Agriculture Kyrgyz-Turkish Manas University Bishkek Kyrgyzstan

In the present study, a biofertilizer on the basis of Streptomyces fumanus gn-2 was used for the treatment of wheat and soybean seeds (dose 104 spore/ml) before planting them in soil with low fertility in order to determine the effect of this biological agent on germination rate;the growth of seedlings, shoots, and the maturation phase of plants;the rhizosphere’s functional biodiversity;and the resistance of these plants to pathogens. Seeds were soaked in the suspension for a period of two or three hours. During the growing season of the crop, no additional fertilizing and spraying of a biopesticide against diseases or pests occurred. Despite the soil having low fertility, low quantities of organic matter, and not having been before used for the cultivation of agricultural plants, this biofertilizer showed a strong stimulatory effect on the growth of seeds and seedlings of wheat and soybeans. The average germination and seed vigor increased by 1.5 - 2.0 times, and the phenophases were accelerated to three to five days. In all phases of vegetation, the ammonifying bacteria in the presence of an antagonist (a biological agent) developed rapidly and were constantly present in significant numbers in the rhizosphere. Streptomyces fumanus introduced into non-sterile soil entered into competition with the local soil microflora and had the ability to colonize the rhizosphere system of plants. The use of a formulation of Streptomyces gn-2 has improved the composition of rhizosphere microflora, attracting saprophytic microorganisms: ammonificators and oligotrophs. The presence of the biocontrol microorganism Streptomyces fumanus in the rhizosphere plays an important role in enhancing the growth and development of useful groups, such as nitrogen-fixing bacteria.

关键词： A Low Fertility Soil A Biofertilizer Streptomyces fumanus gn-2 Wheat and Soybean Seeds stimulatory Effect on Seed Germination Rhizosphere’s Functional Biodiversity

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