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In situ absorption and metabolism of stilbene glycoside in rat

Journal of Pharmaceutical Analysis 2010年第4期22卷 223-232页

作者： Chun-Ying Wang1,Zi-Jian Zhang2,Li-Hong Gong3,Lan-Tong Zhang11.Department of Pharmaceutical Analysis,School of Pharmacy,Hebei Medical University,Shijia-zhuang 050017 2.Hebei Traditional Chinese Medical Hospital,Shijiazhuang 050011 3.Department of Chemistry,Research Institute of Sports Science,Shijiazhuang 050017,China Department of Pharmaceutical Analysis School of Pharmacy Hebei Medical University Shijiazhuang 050017 China Hebei Traditional Chinese Medical Hospital Shijiazhuang 050011 China Department of Chemistry Research Institute of Sports Science Shijiazhuang 050017 China

stilbene glycoside(TSG)has been shown to have many beneficial *** is therefore essential to understand the absorption and metabolism of TSG in *** determined the recovery of TSG and its metabolites(TSG sulfate/glucuronides)in rat gastric contents,gastric mucosa,portal vein plasma,celiac arterial plasma,bile,and urine after administration of 15 mg of TSG in 0.5 mL physiological saline or incubation for 20 min in situ in the stomach of *** 20 min,(64.0±9.8)% of the administered TSG disappeared from the stomach;later,TSG was recovered in both free and conjugated forms in plasma and bile,but not in *** the other hand,only free TSG was detected in the gastric contents and mucosa;it was also detected in the portal vein plasma as(48.1±3.5)% of the total TSG(all forms of TSG).However,the proportion of free TSG in the celiac arterial plasma and bile decreased to 4%-10%.In addition,the proportion of free TSG to total TSG in the liver microsome incubation mixture after TSG was incubated in liver microsome at 37 ℃ for 30 min was very low [(10.6 ± 2.6)%].These results indicate that TSG could be quickly absorbed from the rat stomach,conjugated in liver and excreted in *** novel information would be helpful for the use of TSG as a beneficial natural product which may improve its proposed efficacy in preventing chronic diseases.

关键词： in situ absorption metabolism stilbene glycoside rat

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Novel stilbene glycosides from Polygonum multiflorum

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Acta Botanica Sinica 2002年第12期44卷 1491-1494页

作者：肖凯宣利江徐亚明白东鲁中国科学院上海药物研究所上海200031

Two new stilbene glycosides (1 and 2), together with nine known compounds (3-11), were isolated from the water extract of Polygonum multiflorum Thunb. The structures of the new compounds were elucidated by their chemical properties and spectroscopic analyses, including extensive 2D NMR experiments. Compound 2 showed strong DNA cleavage activity, and compounds 1, 2 and 10 (2, 3, 4′, 5_tetrahydroxy_ trans _stilbene_2_O_β_ D _glucopyranoside) exhibited significant inhibition of lipid peroxidation.

关键词： Polygonum multiflorum stilbene glycoside DNA cleavage activity inhibition of lipid peroxidation

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Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action

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Food Science and Human Wellness 2022年第5期11卷 1177-1182页

作者： Wenping Tang Jianfeng Zhan Shiming Li Yue Liu Chi-Tang Ho Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization Huanggang Normal UniversityHuanggang 438000China Department of Food Science Rutgers UniversityNew Brunswick 08901USA Department of Chemical Biology Rutgers UniversityPiscataway 08901USA

In 2021,there are approximately 537 million adults ageing 20-79 years affected by diabetes worldwide and the number is rising rapidly,hence it is important to manage and control diabetes mellitus and its associated *** is one of the key factors in preventing and combating diseases such as *** as a food and an herbal medicine,Polygonum multiflorum(PM)has been used as an anti-aging tonic,for hair darkening in traditional Chinese medicine for several *** recent research effort of PM has been focused on antioxidant,anti-ageing and anti-tumor *** the present study,we utilized the traditional processing of harvested raw PM,and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract(PME).PME(0.075%)was given to diabetic mice(KK CgAy/J)in drinking water and after 7 weeks,PME-treated mice had significantly lower glucose levels than mice in the diabetic control group(P<0.01).The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintainingβ-cell function.

关键词： Diabetes stilbene glycoside Polygonum multiflorum Hypoglycemic activity Homeostatic model assessment

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