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Two New C21 steroidal glycosides from the Roots of Cynanchum paniculatum

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Natural Products and Bioprospecting 2019年第3期9卷 209-214页

作者： Hai-Li Yu Qin Long Wen-Fang Yi Bao-Jia Yang Yu Song Xiao Ding Shun-Lin Li Xiao-Jiang Hao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Two new C21 steroidal glycosides,paniculatumosides H and I,together with four known ones were isolated from the roots of Cynanchum paniculatum(Bge.)*** structures were identifed by spectroscopic methods including extensive 1D and 2D NMR *** compounds were subjected to detect the anti-tobacco mosaic virus(TMV)activities and their cytotoxities against three human tumor cell lines(SMMC-7721,MDA-MB-231 and A549).The results showed that compounds 1 and 5 exhibited potent protective activities against TMV,while 2,4 and 6 had moderate efects on the SMMC7721 cancer cells viability.

关键词： Cynanchum paniculatum steroidal glycosides Bioactivities NMR data

Two New steroidal glycosides from Fermented Leaves of Agave americana

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Chinese Chemical Letters 2002年第7期13卷 629-632页

作者： Jian Ming JIN Xi Kui LIU Rong Wei TENG Chong Ren YANG Kunming Institute of Botany Chinese Academy of SciencesKunming 650204

Two new spirostanol glycosides named agamenoside A and B, were isolated from the fermented leaves of Agave americana. Their structures were elucidated as (23S, 25R)-5a -spirostan-3b, 6a, 23-triol 3-O-a-L-rhamnopyranosyl-(13)- b-D-glucopyranosyl-(12)-[b-D- xylopyranosyl-(13)]-b-D-glucopyranosyl-(14)-b-D-galactopyranoside (1) and (25R)-5a-spiro- stan-3b, 6a-diol 3-O-b-D-glucopyranosyl-(12)-[ b-D-xylopyranosyl-(13)]- b-D-glucopyra- nosyl-(14)- b-D-galactopyranoside (2) by a combination of chemical and spectral methods.

关键词： Agave americana L. steroidal glycosides agamenosides.

steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity

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Steroidal glycosides from the underground parts of Dracaena ...

Novel cytotoxic steroidal glycosides from the roots of Liriope muscari

第十四届全国中药和天然药物学术研讨会

作者： Liying Tang Zhuju Wang Hongwei Wu Akihito Yokosuk Yoshihiro Mimaki Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Department of Medicinal Pharmacognosy School of PharmacyTokyo University of Pharmacy and Life Sciences

Six new spirostanol glycosides（1-6） and 12 known compounds（7-18） were isolated from the underground parts of Dracaena thalioides（Agavaceae）.The structures of 1-6 were determined by spectroscopic analysis,including 2D NMR spectroscopic data,and chemical *** isolated compounds were evaluated for cytotoxic activity against HL-60 human leukemia *** 1,3-6,and 8-18 showed cytotoxicity against HL-60 cells,of which 10,a bisdesmosidic spirostanol derivative,showed potent cytotoxicity against HL-60 cells with an IC50 value of 0.38 μM and induced apoptosis in HL-60 cells.

关键词： Dracaena thalioides Agavaceae steroidal glycosides spirostanol glycosides cytotoxic activity HL-60 cells apoptosis

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Chinese Journal of Natural Medicines 2015年第6期13卷 461-466页

作者： LI Yong-Wei QI Jin ZHANG Yuan-Yuan HUANG Zhen KOU Jun-Ping ZHOU Shui-Ping ZHANG Yu YU Bo-Yang State Key Laboratory of Natural Medicines Department of Complex Prescription of TCM China Pharmaceutical University Tasly Research and Development Institute Tasly Pharmaceutical Co. Ltd.

The present study was designed to investigate the chemical constituents and bioactivities of the roots of Liriope muscari(Decne.) L.H. Bailey. The compounds were isolated through various chromatography techniques, including silica gel, Sephadex LH-20, and semi-preparative HPLC. The structures were elucidated by infrared(IR), mass spectrometric(MS), 1D- and 2D-NMR analyses in comparison with reference data. In addition, the cytotoxicity of these compounds against human breast cancer MDA-MB-435 cells was evaluated by the MTT assay. Two new steroidal glycosides, 25(R, S)-ruscogenin-1-O-[β-D-fucopyranosyl(1→2)]-[ β-D-xylopyranosyl(1→3)]-β-D-glucopyranoside(Liriopem I, 1) and 25(R, S)- ruscogenin-1-O-[β-D-fucopyranosyl(1→2)]-[β-D-xylopyranosyl(1→4)]-β-D-fucopyranoside(Liriopem II, 2) and two known compounds LM-S6(3) and DT-13(4) were isolated and identified. Liriopem I(1), liriopem II(2) and DT-13(4) showed remarkable cytotoxicity with IC50 values being(0.58 ± 0.08),(0.05 ± 0.10), and(0.15 ± 0.09) μg·m L-1, respectively. In summary, compounds 1 and 2 identified in the present study exerted cytotoxicity against breast cancer cells, providing a basis for future development of these compounds as novel anticancer agents.

关键词： Liriope muscari steroidal glycosides Cytotoxicity

A new steroidal glycosides from roots of Reineckia carnea

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A new steroidal glycosides from roots of Reineckia carnea

Traditional Uses and Phytochemical Constituents of Cynanchum otophyllum C. K. Schneid (Qingyangshen)

中国化学会第十一届全国天然有机化学学术会议

作者： Ju-Yan Zheng Zhao-Xia Liu Kun Zou 三峡大学生物与制药学院

A new spirostanol（1） was isolated from the roots of Reineckia carnea,together with three known Compounds,25（S）-5β-spirostan-1β,3β-dioll-O-α-Lrhamnopyranosyl-（1→2）-β-D-xylopyranoside（2）,β-daucosterol（3）,（25S）-spirostanol-1β,3β,5β,26-tetraol-5-O-β-D-glucopyranoside（4）.Their structures were determined on the basis of chemical methods and spectral data,and their anticancer activities were evaluated by MTT method.

关键词： Reineckia carnea steroidal glycosides structural elucidation anticancer activity NMR

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World Journal of Traditional Chinese Medicine 2023年第1期9卷 1-7页

作者： Christian Bailly Cheng Xiang Ji-HongZhang Oncowitan Scientific Consulting OfficeLille(Wasquehal)59290France Faculty of life Science and Technology Kunming University of Science and TechnologyKunming 650500China Medical School Kunming University of Science and TechnologyKunming 650500China

The roots of the plant Cynanchum otophyllum C. K. Schneid(Apocynaceae), known as Qingyangshen in Chinese, are used for a long time as a traditional medicine by different ethnic communities in the Yunnan province(China). The multiple properties and applications of this herbal medicine have been analyzed. C. otophyllum is a perennial herbal liana, nonedible, and generally wild harvested. A cultivation method has been proposed to increase the fruit set level. Qingyangshen is used essentially to treat epilepsy, rheumatism, or other inflammatory diseases. The plant can be found also in diverse polyherbal preparations used in cosmetic or as food supplement(detox products), and in phyto-preparations claimed to reduce hair loss. The plant is a rich reservoir of C-21 steroidal glycosides. Many bioactive compounds have been isolated from this plant and some of them have been pharmacologically characterized, such as otophyllosides, cynotophyllosides, cynanotins, cynotogenins, cynanchins, all briefly evocated here. The plant presents also interesting features in other domains. In particular, leave extracts of C. otophyllum C. K. Schneid contain proteases which are exploited for the local preparation of a cheese-like milk cake. Qingyangshen herbal preparation can be useful to treat epilepsy and inflammation. It has applications beyond medicine in the cosmetic and food industry.

关键词： Cynanchum epilepsy medicinal plant steroidal glycosides

A new furostanol glycoside from Reineckia carnea

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Journal of Chinese Pharmaceutical Sciences 2014年第3期23卷 177-181页

作者：胡艳维王璇谢可辉涂光忠袁丹付宏征沈阳药科大学中药学院辽宁沈阳110016 北京大学医学部天然药物及仿生药物国家重点实验室北京100191 北京微量化学研究所北京100091

Phytochemical investigations of the aerial parts of Reineckia carnea, collected in Yunnan Province of China, were conducted to explore new chemical constituents. A series of chromatographic and spectroscopic procedures were utilized on the aqueous solution after partitioned with ethyl acetate, which resulted in the separation of a new furostanol-type glycoside and four known compounds. The structures of the isolated compounds were elucidated on the basis of spectroscopic techniques（1D and 2D NMR, IR, HRESIMS） as 26-O-β-D-glucopyranosyl-（25S）-5β-furost-20（22）-en-1α,3β,26-triol-1-O-α-L-arabinopyranosyl-（1→2）-[α-Lrhamnopyranos-yl]-3-O-α-L-rhamnopyranoside（1）,（1β,3β,16β,22S）-cholest-5-en-1,3,16,22-tetrol-1,16-di-（β-D-glucopyranoside）（2）, diosgenin（3）, β-sitosterol（4）, ecdysterone（5）.

关键词： Reineckia carnea steroidal glycosides Steroids Structural identification