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stem cell toxicology:a powerful tool to assess pollution effects on human health

National Science Review 2016年第4期3卷 430-450页

作者： Xinglei Yao Nuoya Yin Francesco Faiola Stake Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences

Environmental pollution is a global problem;the lack of comprehensive toxicological assessments may lead to increased health *** fully understand the health efects of pollution,it is paramount to implement fast,eicient and speciic toxicity screening that relies on human models rather than on time-consuming,expensive and oten inaccurate tests involving live *** stem cell toxicology represents a valid alternative to traditional toxicity assays because it takes advantage of the ability of stem cells to diferentiate into multiple cell types and tissues of the human ***,this branch of toxicology provides a possibility to assess cellular,embryonic,developmental,reproductive and functional toxicity in vitro within a single system highly relevant to human *** this review,we describe the development,performance and future perspectives of stem cell toxicology,with an emphasis on how it can meet the increasing challenges posed by environmental pollution in the modern world.

关键词： stem cell toxicology embryonic stem cells mesenchymal stem cells environmental pollution environmental toxicology health efects

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Profiling biotoxicities of hexafluoropropylene oxide trimer acid with human embryonic stem cell-based assays

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Journal of Environmental Sciences 2022年第6期34卷 34-42页

作者： Shengxian Liang Guoqiang Liang Yue Zhang Xiufang Zhang Li Zhong Institute of Life Sciences and Green Development College of Life SciencesHebei UniversityBaoding 071000China Western University of Health Sciences PomonaCalifornia 91766USA

Hexafluoropropylene oxide trimer acid(HFPO-TA), an emerging replacement of perfluorooctanoic acid(PFOA), has recently been reported to be a potential environmental *** to the similar structure to PFOA, HFPO-TA may cause comparable adverse effects on human health. Therefore, evaluating the toxic profiles of HFPO-TA has become an urgent *** this study, we investigated the cytotoxicity and hepatoxicity of HFPO-TA using human embryonic stem cell(h ESC)-based assays. Results showed that HFPO-TA reduced h ESCs’ viability in a dose dependent manner, and the calculated IC50 for 24, 48 and 72 hr were 222.8,167.4, and 80.6 μmol/L, respectively. Significant intracellular ROS accumulation and mitochondrion membrane potential reduction were detected with HFPO-TA exposure, and increased apoptotic/necrotic cells were also observed in high dose of HFPO-TA treated ***, HFPO-TA at noncytotoxic concentrations also significantly impaired the functions of induced hepatocytes by diminishing cell glycogen storage ability and deregulating specific functional genes. Transcriptome sequencing analysis identified a set of hepatic associated biological processes responding to HFPO-TA exposure. PPAR was the most significantly enriched pathway. Genes including FGA, FGB, FGG, AHSG, HRG, ITIH2, ALB were characterized as hub genes by cyto Hubba plug-in. These data indicated that HFPO-TA is a potential hepatotoxicant, and may not be a safe replacement for PFOA.

关键词： Hexafluoropropylene oxide trimer acid(HFPO-TA) stem cell toxicology Hepatoxicity Transcriptional analysis

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