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stem cell homing-based tissue engineering using bioactive materials

Frontiers of Materials Science 2017年第2期11卷 93-105页

作者： Yinxian YU Binbin SUN Chengqing YI Xiumei MO Department of Orthopaedic Surgery Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200080 China State Key Lab for Modification of Chemical Fibers & Polymer Materials College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China

Tissue engineering focuses on repairing tissue and restoring tissue functions by employing three elements： scaffolds, cells and biochemical signals. In tissue engineering, bioactive material scaffolds have been used to cure tissue and organ defects with stem cell-based therapies being one of the best documented approaches. In the review, different biomaterials which are used in several methods to fabricate tissue engineering scaffolds were explained and show good properties （biocompatibility, biodegradability, and mechanical properties etc.） for cell migration and infiltration. stem cell homing is a recruitment process for inducing the migration of the systemically transplanted cells, or host cells, to defect sites. The mechanisms and modes of stem cell homing-based tissue engineering can be divided into two types depending on the source of the stem cells： endogenous and exogenous. Exogenous stem cell-based bioactive scaffolds have the challenge of long-term culturing in vitro and for endogenous stem cells the biochemical signal homing recruitment mechanism is not clear yet. Although the stem cell homing-based bioactive scaffolds are attractive candidates for tissue defect therapies, based on in vitro studies and animal tests, there is still a long way before clinical application.

关键词： stem cell homing cell migration cell proliferation tissue engineering scaffold biochemical signals

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