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Targeting CXCR4 and EDN1 for the treatment of recurrent miscarriage using stearic acid from traditional Chinese medicine

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Traditional Medicine Research 2024年第11期9卷 65-75页

作者： Fang Liu Dong-Mei Shi Wen-Ye Ma Da-Wei Tang Gang Bai Xin-You Yu Reproductive Center of Yinchuan Maternal and Child Health Hospital Yinchuan 750001China Prenatal Diagnosis Center of Ningxia Medical University General Hospital Yinchuan 750004China

Background:Recurrent miscarriage(RM)affects an estimated 1-3%of couples attempting to conceive,and its molecular components stay ineffectively caught *** study aims to explore potential therapeutic targets for RM by examining gene expression patterns and biological pathways in both mouse and human RM ***,explore relevant traditional Chinese medicine(TCM)components targeting potential therapeutic ***:We utilized the GSE211251 mouse and the GSE26787 human datasets,employing gene set enrichment analysis and gene metaphysics analysis to examine differentially expressed genes and enriched ***-cell RNA analysis uncovered cellular heterogeneity and arranged pharmacology-mapped potential drug-target *** employed molecular docking strategies to assess the affinity of TCM components for key ***:In the mouse model,genes such as Ly6f1 and Gpr26 were upregulated,while Stc5a and Galca exhibited *** set enrichment analysis identified key pathways,including the tumor necrosis factor-mediated signaling *** human samples,Gene Ontology analysis highlighted processes such as apoptosis and cell ***-cell RNA analysis revealed distinct cellular populations between normal and RM *** pharmacology identified C-X-C motif chemokine receptor 4(CXCR4)and endothelin 1(EDN1)as potential key targets,and molecular docking confirmed that stearic acid from TCM appears to regulate these ***:This study presents a comprehensive analysis of the genetic and cellular underpinnings of RM,identifying CXCR4 and EDN1 as promising therapeutic *** acid from TCM could provide targeted treatment by modulating these key proteins,paving the way for new RM treatment strategies.

关键词： RM gene expression single-cell RNA analysis CXCR4 EDN1 stearic acid

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Modified sepiolite stabilized stearic acid as a form-stable phase change material for thermal energy storage

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International Journal of Minerals,Metallurgy and Materials 2023年第9期30卷 1835-1845页

作者： Chuanchang Li Xinke Peng Jianjun He Jian Chen Key Laboratory of Renewable Energy Electric-Technology of Hunan Province School of Energy and Power EngineeringChangsha University of Science and TechnologyChangsha 410114China

Sepiolite(ST) was used as a supporting matrix in compiste phase change materials(PCMs) due to its unique microstructure, good thermal stability, and other raw material advantages. In this paper, microwave acid treatment were innovatively used for the modification of sepiolite. The modified sepiolite(ST_(m)) obtained in different hydrochloric acid concentrations(0.25, 0.5, 0.75, and 1.0 mol·L^(-1)) was added to stearic acid(SA) via vacuum impregnation method. The thermophysical properties of the composites were changed by varying the hydrochloric acid concentration. The SA-ST_(m0.5)obtained by microwave acid treatment at 0.5 mol·L^(-1)hydrochloric acid concentration showed a higher loading capacity(82.63%) than other composites according to the differential scanning calorimeter(DSC) analysis. The melting and freezing enthalpies of SA-ST_(m0.5)were of 152.30 and 148.90 J·g^(-1), respectively. The thermal conductivity of SA-ST_(m0.5)was as high as 1.52 times that of pure SA. In addition, the crystal structure, surface morphology, and microporous structure of ST_(m)were studied, and the mechanism of SAST_(m0.5)performance enhancement was further revealed by Brunauere Emmett Teller(BET) analysis. Leakage experiment showed that SAST_(m0.5)had a good morphological stability. These results demostrate that SA-ST_(m0.5)has a potential application in thermal energy storage.

关键词： sepiolite stearic acid phase change materials thermal energy storage

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Study on Sustained-Release Pesticides Blended with Fosthiazate-stearic acid/Expanded Perlite

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Journal of Renewable Materials 2023年第1期11卷 257-272页

作者： Huimin Huang Zijun Wu Zhijian Zhou Qiulin Xu Jie Yan Qiaoguang Li College of Chemistry and Chemical Engineering Zhongkai University of Agriculture and EngineeringGuangzhou510225China College of Light Industry and Food Science Zhongkai University of Agriculture and EngineeringGuangzhou510225China

The low utilization rate of pesticides makes the migration of pesticides in water and soil,which brings great harm to the *** development of pesticide carriers with good drug loading capacity and release control abil-ity is an effective method to realize effective utilization of pesticides and reduce pesticide *** this work,fosthiazate-stearic acid/expanded perlite sustained-release particles were successfully prepared by vacuum impregnation using expanded perlite(EP)as carrier,fosthiazate(FOS)as model pesticide and stearic acid(SA)as hydrophobic *** structure and morphology of the samples were studied by BET,FT-IR,TGA,XRD,DSC and *** effects of different mass ratios of FOS to SA on loading capacity and release rate at 24 h were *** sustained release behavior of FOS-SA/EP at different temperatures and pH values was investigated by static dialysis bag *** results showed that FOS and SA were adsorbed in EP pores by physical *** the mass ratios of FOS to SA decreasing from 7:3 to 3:7,the 24 h release rate of FOS-SA/EP decreased from 18.77%to 8.05%,and the drug loading decreased from 461.32 to 130.99 mg/***-SA/EP showed obvious temperature response at 25℃,30℃ and 35℃,the cumulative release rate(CRR)of 200 h were 33.38%,41.50%and 51.17%,*** pH=5,the CRR of FOS was higher than that of pH=7,and the CRR of FOS for 200 h were 49.01%and 30.12%,*** different temperatures and pH=5,the release mechanism of FOS-SA/EP belongs to the Fickian diffusion mechanism;When pH=7,the diffusion mechanism is dominant,and the dissolution mechanism is complementary.

关键词： Expanded perlite fosthiazate stearic acid sustained release release kinetics

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Design of a stearic acid/boron nitride/expanded graphite multifiller synergistic composite phase change material for thermal energy storage

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Energy and Built Environment 2023年第5期4卷 557-567页

作者： Ci Ao Suying Yan Long Zhao Xiaoyan Zhao Yuting Wu College of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot 010051China College of Environmental and Energy Engineering Beijing University of TechnologyBeijing 100124China

In order to solve the problems of low thermal conductivity and easy liquid leakage of a stearic acid(SA),the composite phase change material(PCM)was prepared by adding boron nitride(BN)and expanded graphite(EG)to melted SA,and its thermal conductivity,crystal structure,chemical stability,thermal stability,cycle stability,leakage characteristics,heat storage/release characteristics,and temperature response characteristics were *** results showed that the addition of BN and EG significantly improved the thermal conductivity of the material,and they efficiently adsorbed melted *** maximum load of SA was 76 wt.%and there was almost no liquid ***,the melting enthalpy and temperature were 154.20 J·g^(−1) and 67.85℃,*** with pure SA,the SA/BN/EG composite showed a lower melting temperature and a higher freezing *** addition,when the mass fraction of BN and EG was 12 wt.%,the thermal conductivity of the composite was 6.349 W·m^(−1)·K^(−1),which was 18.619 times that of *** importantly,the composite showed good stability for 50 cycles of heating and cooling,and the SA/BN/EG-12 hardly decomposes below 200℃,which implies that the working performance of the composite PCM is relatively stable within the tem-perature range of 100℃.Therefore,the composite can exhibit excellent thermal stability in the field of building heating.

关键词： stearic acid Boron nitride Expanded graphite Phase change material Thermal properties

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Surface properties of superfine alumina trihydrate after surface modification with stearic acid

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International Journal of Minerals,Metallurgy and Materials 2015年第5期22卷 537-542页

作者： Gui-hua Liu Bo-hao Zhou Yun-feng Li Tian-gui Qi Xiao-bin Li School of Metallurgy and Environment Central South University

The surface properties of superfine alumina trihydrate （ATH） after surface modification were studied by measuring the contact angle, active ratio, oil adsorption, total organic carbon, adsorption ratio, and Fourier transform infrared （FTIR） spectrum. The contact angle increased initially and then slowly decreased with an increase of the amount of stearic acid. However, the surface flee energy decreased ini- tially and then increased. Surface modification with stearic acid or sodium stearate can benefit from elevating temperature. The base surface tension component and the free energy of Lewis acid-base both declined sharply following the surface modification. Excess stearic acid was physically adsorbed in the form of multilayer adsorption, and an interaction between oxygen on the ATH surface and hydroxyl in stearic acid was subsequently determined. Our results further indicated that the contact angle and adsorption ratio can be used as control indicators for surface modification compared with active ratio, oil adsorption and total organic carbon.

关键词： alumina trihydrate surface modification stearic acid surface flee energy surface tension contact angle

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Synthesis of Mesoporous, Nanocrystalline Lanthanum Phosphate in the Presence of Citric acid and stearic acid

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Journal of Rare Earths 2007年第6期25卷 684-691页

作者： Li-Ngee Ho Hiroyasu Nishiguchi Katsutoshi Nagaoka Yusaku Takita Department of Applied Chemistry Oita University Dannoharu 700 Oita 870-1192 Japan

Lanthanum phosphate was prepared in the presence of citric acid and stearic acid under methanolic conditions at pH 4.5 and pH 7, respectively. The samples obtained were intensively characterized using X-ray diffraction, nitrogen adsorption-desorption isotherm study, transmission electron microscopy （TEM）, thermal gravimetric and differential thermal analysis, and Fourier transform infrared （FTIR） analysis . The as-synthesized samples prepared at pH 4.5 showed lamellar mesostruroned form with high crystallinity. Results showed that the pore size and pore volume changed when the materials were prepared under different pH conditions. Morphology of the samples was observed by using TEM, which showed that the samples possessed relatively small particles closely packed together. The as-synthesized samples were investigated using FTIR, and the mesopore formation mechanism was discussed.

关键词： mesoporous lanthanum phosphate citric acid stearic acid nanocrystalline rare earths

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Effect of stearic acid on Ettringite Formation

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Journal of Materials Science & Technology 2002年第3期18卷 263-265页

作者： Essam A.KisharDepartment of Chemistry, Faculty of Girls, Ain Shams University, Cairo, Egypt [ Manuscript received March 29, 2001, in revised form June 11, 2001] Dept. of Chem. Faculty of Girls Ain Shams Univ. Cairo Egypt

The hydration reaction of a mixture of tricalcium aluminate (C3A) and gypsum with the molar ratio of 1:3 was carried out at room temperature and a water/solid ratio of 4.0. The hydration was carried out in presence of 0, 1 and 3% stearic acid and the mixes were designated as A, B and C, respectively. Ettringite was the only hydration product formed in the presence and absence of stearic acid. Phase composition, microstructure, infra-red analysis as well as degree of hydration were carried out for the different hydration mixtures. The rate of ettringite formation in the presence of 3% stearic acid was accelerated during the first half hour of hydration, and then retardation was occurred. In the presence of 1% stearic acid the ettringite formation was accelerated first till 3 days, then retardation was observed at later hydration ages.

关键词： stearic acid Hydration Ettringite

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Synthesis of stearic acid triethanolamine ester over solid acid catalysts

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Chinese Chemical Letters 2010年第9期21卷 1020-1024页

作者： Tao Geng Qiu Xiao Li Ya Jie Jiang Wei Wang College of Chemistry and Chemical Engineering Taiyuan University of Technology Taiyuan 030024 China China Research Institute of Daily Chemical Industry Taiyuan 030001 China

The synthesis of stearic acid triethanolamine ester over solid acid catalysts was *** results showed that the catalytic activity and selectivity of zirconium sulfate supported on SBA-15（6）（pore diameter 6 nm） is better than that of commonly used hypophosphorous acid,zirconium sulfate supported on MCM-41 and zirconium sulfate supported on SBA-15（9）（pore diameter 9 nm）.

关键词： Zirconium sulfate SBA-15 stearic acid Triethanolamine

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Solubility of stearic acid in supercritical CO_2-acetonitrile mixtures

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Chinese Journal of Chemistry 1999年第3期17卷 231-236,201页

作者：毛灿鲁洁韩布兴闫海科 Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

The solubility of stearic acid in supercritical CO2 with acetonitrile (CH3CN) cosolvent was measured at 318.15 K in the pressure range from 9.5 to 16.5 MPa, and the cosolvent concentration ranges from 0. 0 to 5.5 mol% . The solubility increases with acetonitrile concentration and pressure, and it also increases with the apparent density of CO2 d1(moles of CO2 in per liter of fluid) at higher cosolvent concentrations. At lower d1, however, the solubility of the acid at lower acetonitrile concentrations is lower than that in pure CO2 provided that d1 is fixed, which is discussed qualitatively based on the clustering of the components in the system.

关键词： Green chemistry solid-fluid equilibria supercritical CO2 stearic acid acetonitrile

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Molecular Dynamic Studies on Langmuir Monolayers of stearic acid

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Chemical Research in Chinese Universities 2013年第3期29卷 545-550页

作者： KONG Chui-peng ZHANG Hong-xing ZHAO Zeng-xia ZHENG Qing-chuan State Key Laboratory of Theoretical and Computational Chemistry Institute of Theoretical Chemistry Jilin University Changchun 130021 P. R. China

Compression isotherm for stearic acid was obtained by means of molecular dynamic simulation and compared to experimentally measured values for the Langmuir monolayers. Compared to the previous simulation, the present simulation has provided a method to reproduce the compression of the monolayer. The result is consistent with other experimental results. By analyzing the alkyl tails, the configuration of stearic acid molecules during the compression process was studied and a uniform monolayer was obtained after compression. stearic acid molecules were observed to form fine organized monolayer from completely random structure. Hexatic order of the arrangement has been identified for the distribution of stearic acid molecules in the monolayer. At the end of the compression, the stearic acid molecules were tightly packed in the gap of two other molecules. At last, the hydrogen bonds in the system were analyzed. The main hydrogen bonds were from stearic acid-water interaction and their intensities constantly decreased with the decreased of surface area per molecule. The weak hydrogen bond interaction between stearic acid molecules may be the reason of easy collapse.

关键词： stearic acid Monolayer Molecular dynamics

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