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spontaneous remission of Pneumocystisjiroveci pneumonia in 2 non-AIDS immunocompromised patients

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Chinese Medical Journal 2013年第1期126卷 184-185页

作者： MU Xiang-dong WANG Guang-fa MA Jing ZHANG Cheng SU Li CHEN Jian Department of Respiratory Medicine Peking University FirstHospital Beijing 100034 China

Pneumocystis jiroveci （P. jiroveci） pneumonia （PCP） in non-AIDS immunocompromised patients ismuch more critical than that in AIDS patients,1 Without treatment, mortality of PCP in immunocompromised patients approaches 100 percent, and there were no reports of spontaneous remissions of PCP without anti-PCP therapy.2 Here we report 2 non-AIDS immunocompromised patients in whom PCP developed and remitted without treatment.

关键词： Pneumocystis jiroveci pneumonia non-AIDS immunocompromised patients spontaneous remission

spontaneous remission of autoimmune pancreatitis: Four case reports

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World Journal of Clinical Cases 2022年第23期10卷 8232-8241页

作者： Bin-Bin Zhang Jian-Wei Huo Zheng-Han Yang Zhen-Chang Wang Er-Hu Jin Department of Radiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Radiology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China

BACKGROUND Autoimmune pancreatitis(AIP)is a particular type of chronic pancreatitis,and steroid treatment of AIP is *** remission(SR)of AIP without steroids is relatively *** international consensus for the treatment of autoimmune pancreatitis suggests that patients with AIP with obstructive jaundice,abdominal pain,and back pain related to the pancreas or the bile duct should be treated with steroids;most asymptomatic patients with AIP may improve without ***,in our clinical work,we found that the clinical characteristics of AIP patients with SR *** of these cases are described *** addition,to our knowledge,there is no previously published report of dynamic imaging before and after SR of AIP at *** SUMMARY We present the cases of four patients with AIP(two females and two males)in which the AIP improved spontaneously without steroid *** patients were asymptomatic,one patient had abdominal pain with obstructive jaundice,and one patient had intermittent right upper abdominal *** patients presented with localized pancreatic enlargement and one with diffuse pancreatic *** addition to the pancreatic lesions,bile duct involvement was seen in two patients,and no extra-pancreatic organ involvement was found in the other two *** serum IgG4 level of all patients was more than twice the normal *** SR in the four patients,the affected pancreases exhibited three types of image features:Return to normal,progressive fibrosis,and atrophy and *** The clinical features of SR in our four patients with AIP differ,but the imaging findings share some *** SR,in some cases the affected pancreas could return to normal,although some patients suffer from progressive fibrosis and atrophy as well as calcification.

关键词： Autoimmune pancreatitis spontaneous remission Computed tomography Magnetic resonance imaging Case report

Clinical Features of spontaneous remission in the Classic Fever of Unknown Origin:A Retrospective Study

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Chinese Medical Sciences Journal 2022年第2期37卷 134-141页

作者： Changyi Liu Xiaoqing Liu Xiaochun Shi School of Basic Medicine Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Infectious Diseases Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Centre for Tuberculosis Research Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Clinical Epidemiology Unit International Epidemiology NetworkChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To summarize the clinical features of spontaneous remission in classic fever of unknown origin(FUO).Methods Medical records of 121 patients diagnosed with FUO at admission in Peking Union Medical College Hospital between January 2018 and June 2018 were reviewed *** who were discharged without etiological diagnoses were followed for 2 *** clinical features and outcomes of these patients were *** logistic regression was used to analyze related factors of spontaneous remission of *** After excluding 2 patients who lost to follow-up,the etiology of 119 FUO patients were as follows:infectious diseases in 30(25.2%)cases,connective tissue diseases in 28(23.5%)cases,tumor diseases in 8(6.7%)cases,other diseases in 6(5.0%)cases,and unknown diagnoses in 47(39.5%)***,41 patients experienced spontaneous remission of fever(the median time from onset to remission was 9 weeks,ranging from 4 to 39 weeks).In patients with spontaneous remission in FUO,lymphadenopathy was less common clinical manifestation,the levels of inflammatory markers including leukocyte count,neutrophil count,neutrophil ratio,C-reactive protein,and ferritin were lower,and the proportion of CD8 positive T lymphocytes expressing CD38 was *** logistic regression analysis of factors with a P-valuespontaneous remission in *** This study suggested that most patients discharged with undiagnosed classic FUO would remit ***,for patients with stable clinical conditions,follow-up and observation could be the best *** with lower level of some inflammatory factors may have a high likelihood of spontaneous remission in classic FUO.

关键词： fever of unknown origin follow-up spontaneous remission diagnosis

Three Times spontaneous remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors:a Case Report and Literature Review

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Chinese Medical Sciences Journal 2013年第1期28卷 58-60页

作者： Bao-zhi Fang Guang-sheng He Hai-xia Zhou Hui-rong Chang De-pei Wu Ai-ning Sun Su-ning Chen Jiangsu Institute of Hematology Key Laboratory of Thrombosis and Hemostasis of Ministry of HealthThe First Affiliated Hospital of Soochow University The Affiliated Suzhou Hospital of Nanjing Medical University(Suzhou Municipal Hospital)

APLASTIC anemia （AA） is a bone marrow failure disease caused by abnormal activation of T lymphocytes, resulting in the apoptosis of he- matopoietic cells and bone marrow failure.

关键词： aplastic anemia granulocyte transfusion spontaneous remission related donor

Antibiotic and glucocorticoid-induced recapitulated hematological remission in acute myeloid leukemia:A case report and review of literature

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World Journal of Clinical Cases 2022年第22期10卷 7890-7898页

作者： Xiao-Yun Sun Xiao-Dong Yang Xiao-Qiu Yang Bo Ju Nuan-Nuan Xiu Jia Xu Xi-Chen Zhao Department of Hematology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Pharmacology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina

BACKGROUND Leukemic hematopoietic cells acquire enhanced self-renewal capacity and impaired *** emergence of symptomatic leukemia also requires the acquisition of a clonal proliferative *** leukemia patients usually experience an aggressive ***,spontaneous remission occasionally occurs in patients with acute myeloid leukemia(AML),most frequently after recovery from a febrile episode,and this is generally attributed to the triggering of antineoplastic *** may be another explanation for the spontaneous remission as implicated in this *** SUMMARY A 63-year-old Chinese man presented with high fever,abdominal pain and urticaria-like skin *** was diagnosed with AML-M4 with t(8;21)(q22;q22)/RUNX1-RUNX1T1 based on morphological,immunological,cytogenetic and molecular *** had a complex chromosome rearrangement of 48,XY,t(8;21)(q22;q22),+13,+13[9]/49,idem,+mar[9]/49,idem,+8[2].He also had a mutated tyrosine kinase domain in fms-like tyrosine kinase 3 *** was treated with antibiotics and glucocorticoids for gastrointestinal infection and urticaria-like skin *** infection and skin lesions were quickly ***,he achieved hematological remission along with resolution of the febrile episode,gastrointestinal symptoms and skin ***,after relapse,repeating these treatments resulted in a return to hematological ***,he demonstrated strong resistance to antibiotic and glucocorticoid treatment after the second relapse and died of sepsis from bacterial infection with multidrug *** main clinical feature of this patient was that symptomatic AML emerged with flaring of the gut inflammatory disorder and it subsided after resolution of the *** from the present case raises the possibility that in a subgroup of AML patients,the proliferative advantage of leukemia cells may critically require the presence of inflammatory ***

关键词： Acute myeloid leukemia Fms-like tyrosine kinase 3 tyrosine kinase domain Glucocorticoid Antibiotic spontaneous remission Gastrointestinal infection Case report

Natural regression of fibrosis in chronic hepatitis B

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World Journal of Gastroenterology 2016年第24期22卷 5459-5466页

作者： Shogo Ohkoshi Haruka Hirono Kazuhiko Watanabe Katsuhiko Hasegawa Kenya Kamimura Masahiko Yano Department of Internal Medicine School of Life Dentistry at Niigata The Nippon Dental University Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

The fibrosis of liver cirrhosis was considered to be irreversible before the anti-viral drugs showed that it is reversible when they lead to continuous suppression of viral replication and inflammation. However, several reports previously showed that fibrosis of type B liver cirrhosis was almost completely absorbed after the natural remission of chronic inflammation. This phenomenon might not be limited to exceptional patients, but rather occur commonly, considering the dynamic clinical features of chronic hepatitis B(CHB), where inactive carrier stage normally follows aggravation of hepatitis and progression of fibrosis at the time of HBe Ag seroconversion. Thus, fibrosis levels of CHB as a hepatocellular carcinoma(HCC)-surveillance marker, particularly those of the inactive stage, could be underestimated, because some of them might have been(pre)cirrhotic in the past and recovered with the natural regression of fibrosis. We argue that cirrhosisinduced HCC mechanisms, rather than direct action of viral genome, may be more common than generally considered in CHB patients. This may have some impact on reconsidering the surveillance rationale for HCC in CHB, from where advanced HCCs tended to be missed. In addition, a molecular marker to assess the cancer-prone characteristics of the liver will definitely be needed to resolve the issue.

关键词： Chronic hepatitis B Cirrhosis spontaneous remission Regression of fibrosis Occult hepatitis B infection Hepatocellular carcinoma surveillance of hepatitis B virus

Spontanous remission of PAN

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Open Journal of Gastroenterology 2023年第11期13卷 377-381页

作者： Arowa Abdelgadir Srinivasa Elamanchi Department of Acute Medicine Walsall Manor Hospital Walsall UK Sandwell and West Birmingham Hospitals NHS TRUST Lyndon UK

Polyarteritis nodosa (PAN) affects mostly medium-sized arteries and sometimes small ones as well. The primary methods used to make the diagnosis are through physical examinations, biopsies of organs that are affected, and/or angiographic studies. Immunosuppressants like glucocorticoids and cyclophosphamide are usually started as soon as possible after a diagnosis. So, it’s not clear if sudden remission of PAN happens or not. Here we present a 42-year-old male who presented with right upper quadrant, right flank pain and fever. CT angiogram Aorta revealed soft tissue rind around the small to medium sized vessel in the abdomen and bilateral cortical renal infarcts of variable age in the right more than the left. A diagnosis of polyarteritis nodosa was made and the patient achieved spontaneous remission with no need for corticosteroids or immunosuppressive therapy.

关键词： Polyarteritis Nodosa (PAN) spontaneous remission