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splicing factor proline and glutamine-rich is a prognostic biomarker and correlated with clinical pathologic features and immune infiltrates in hepatocellular carcinoma

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Medical Data Mining 2024年第2期7卷 45-59页

作者： Chao-Ran Zhu Shi-Chen Zhu Clinical and Basic Medical Sciences College Shandong First Medical UniversityJinan 250021China Department of Surgery Jinan Changqing District Traditional Chinese Medicine HospitalJinan 250021China

Background:Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-related deaths *** factor proline and glutamine-rich(SFPQ)is a multifunctional protein that controls various biological *** a potential therapeutic target and a promising prognostic indicator,the potential effects and processes of SFPQ in HCC require further ***:The RNA sequencing data were obtained from the Gene Expression Omnibus,International Cancer Genome Consortium,and The Cancer Genome Atlas databases to analyze SFPQ expression and differentially expressed genes(DEGs).We utilized the LinkedOmics database to identify co-expressed genes.A Venn diagram was constructed to determine the overlapping genes between the DEGs and the co-expressed *** enrichment analysis was performed on the overlapping genes and ***,our study involved functional enrichment analysis,a protein-protein interaction network analysis,and an analysis of immune cell *** cBioPortal and Tumor Immune Single-cell Hub were utilized to investigate the genetic alterations of SFPQ and the single-cell transcriptome visualization of the tumor microenvironment.A ceRNA network was established with the assistance of the ENCORI ***,we elucidated the clinical significance of SFPQ in HCC by employing Kaplan-Meier survival analysis,univariate and multivariate Cox regression,and prognostic nomogram ***:The expression of SFPQ in HCC tissues was significantly elevated compared to normal *** results indicated that increased expression of SFPQ was associated with pathways related to *** ceRNA network,including SFPQ,hsa-miR-101-3p,AC023043.4,AC124798.1,AC145207.5,and GSEC,was constructed with the assistance of *** SFPQ expression was related to a poor prognosis in HCC and its *** and multivariate Cox regression analysis showed that elevated SFPQ expression is an independent predictive ***

关键词： biomarker splicing factor proline and glutamine-rich prognosis immune infiltration hepatic cell carcinoma

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