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Study on the Resolving phlegm Effect of D-Limonene in Mice with spleen deficiency and phlegm-dampness syndrome

World Journal of Traditional Chinese Medicine 2023年第4期9卷 430-437页

作者： Jie Luo Long-Jing Wang Yang-Song Li Jin Zhang Gui-Rong Zhang Fei Long Teng Peng Jie Yan Bao-Jie Zhu School of Pharmacy/School of Modern Chinese Medicine Industry Chengdu University of Traditional Chinese Medicine State Key Laboratory of Characteristic Chinese Drug Resources in Southwest China ChengduChina

Objective:According to Traditional Chinese Medicine theory,spleen deficiency and phlegm-dampness syndrome(SDPDS)are caused by abnormal water metabolism in the body because of spleen *** purpose of this article was to evaluate the efficacy of D-limonene(DL)in resolving phlegm in mice with SDPDS from the perspective of regulating the level of aquaporin 3(AQP3).Methods:The model of SDPDS was induced in mice using the multifactor modeling method,which combines internal and external *** artificial climate box was used to create a humid environment,whereas the irregular diet was caused by different feeding methods on odd-even *** mice were divided into blank control,model group,DL low-dose,DL high-dose,and positive *** mice were modeled and treated for 7 *** of gastrin and amylase(AMS)in the serum,mucus secretion in the trachea,and AQP3 in the tissue near the gastric ***:DL significantly reduced mucus secretion in the trachea(P<0.001).It also increased the level of AMS in the serum(P<0.01)and decreased the level of AQP3 in the gastric tissue(P<0.01).Conclusions:Mice with SDPDS exhibited disturbed water metabolism and significantly increased AQP3 *** can restore the levels of AQP3 and plays an important role in resolving *** study may also help expand the efficacy of natural drugs containing DL and improve the utilization of natural drug resources.

关键词： Aquaporins D-limonene phlegm spleen deficiency and phlegm-dampness syndrome stomach

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