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Antioxidant and antipyretic properties of methanolic extract of Amaranthus spinosus leaves

Asian Pacific Journal of Tropical Medicine 2010年第9期3卷 702-706页

作者： Bagepalli Srinivas Ashok Kumar Kuruba Lakshman Jayaveera KN Devangam Sheshadri Shekar Avalakondarayappa Arun Kumar Bachappa Manoj Department of Pharmacognosy Sri K.V.College of PharmacyChickballapurKarnatakaIndia Department of Pharmacognosy PES College of PharmacyBangaloreKarnatakaIndia Department of Chemistry Jawaharlal Nehru Technological University of College of EngineeringAnantapurAndhra PradeshIndia Department of Pharmacology Sri K.V.College of PharmacyChickballapurKarnatakaIndia

Objective:Methanolic extract of Amaranthus spinosus（***） leaves was screened for antioxidant and antipyretic ***:Antioxidant activity was measured by l,l-diphenyl-2-picryl-hydrazile（DPPH） free radical scavenging,superoxide anion radical scavenging,hydroxyl free radical scavenging,nitric oxide radical scavenging,2,2 -azinobis-3- ethylbenzothiazole-6-sulfonic acid（ABTS） radical scavenging assays and total phenolic content was also *** activity of methanolic extract of *** was measured by yeast induced pyrexia method at concentration of 200 and 400 mg/kg using paracetamol as standard ***:Methanolic extract of *** showed potent antioxidant *** IC50 value was（87.50±3.52）μg/mL,（98.80±1.40）μg/mL,（106.25±0.20）μg/mL,（88.70±0.62）μg/mL and（147.50±2.61）μg/mL for DPPH,superoxide,hydroxyl,nitric oxide and ABTS radical scavenging *** extract of A spinosus showed significant（P<0.01） antipyretic activity.

关键词： Amaranthus spinosus Antioxidant activity Antipyretic activity

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The Synthesis of Gold Nanoparticles Using <i>Amaranthus spinosus</i>Leaf Extract and Study of Their Optical Properties

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Advances in Materials Physics and Chemistry 2012年第4期2卷 275-281页

作者： Ratul Kumar Das Nayanmoni Gogoi Punuri Jayasekhar Babu Pragya Sharma Chandan Mahanta Utpal Bora Bioengineering Research Laboratory Department of Biotechnology Indian Institute of Technology Guwahati Guwahati India Biotech Hub Centre for the Environment Indian Institute of Technology Guwahati Guwahati India Department of Civil Engineering Indian Institute of Technology Guwahati Guwahati India

We report here the application of a medicinally important plant Amaranthus spinosus for the synthesis of gold nanoparticles (AuNPs). Different concentrations of ethanolic leaf extract of the plant were reacted with aqueous solution of HAuCl4·4H2O under mild reaction conditions. Synthesis of AuNPs was confirmed from the UV-Vis study of surface plasmon resonance property of the colloidal solution. Transmission electron microscopy (TEM) revealed particles as spherical and triangular in shape. X-ray diffraction (XRD) confirmed the crystalline nature of AuNPs with average size of 10.74 nm as determined by Debye-Scherrer’s Equation. Fourier transform infra-red (FT-IR) analysis of leaf extract and lyophilized AuNPs showed the presence of various functional groups present in diverse phytochemicals. Energy dispersive X-ray (EDX) of purified AuNPs confirmed the formation of AuNPs and surface adsorption of biomolecules. We further investigated the toxicity of the synthesized AuNPs and found non toxic to the cancer cell lines and could be used for biomedical applications.

关键词： Gold Nanoparticles Leaf Extract Anti-Oxidant Amaranthus spinosus Crystal Growth

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Pain management in mice using methanol extracts of three plants belongs to family Amaranthaceae

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Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 527-530页

作者： Ashok Kumar BS Lakshman K Jayaveera KN Vel Murgan C Arun Kumar PA Vinod Kumar R Meghda Hegade Sridhar SM Department of Pharmacognosy.Sri K.V.College of Pharmacy ChickballapurKarnataka-562101India Department of Pharmacognosy PES College of PharmacyBangaloreKarnatakaIndia Department of Chemistry Jawaharlal Nehru Technological University of College of EngineeringAnantapurAndhra Pradesh.India Department of Pharmacology Sri K.V.College of PharmacyChickbaltapurKarnataka-562101.India Department of Pharmacology Sri K.V.College of PharmacyChickballapurKarnataka-562101India

Objective:To investigate the analgesic activity of methanolic extract of Amaranthus viridis(A. viridis),Amaranthus caudatus(***) and Amaranthus spinosus(***).Methods:In this study,the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg/kg were investigated by acetic acid-induced writhings test,hot plate test and tail immersion test for ***:It was found that all the three plants showed significant pain management effect(P<0.01) at a dose of 400 mg/kg,but showed a less significant effect at a dose of 20 mg/kg in the entire tests used for evaluation of analgesic activities(P<0.05).Conclusions:Methanol extracts of ***,*** and *** show potent analgesic activities,and this study provides the scientific proof for their traditional claims.

关键词： Amaranthus viridis Linn Amaranthus caudatus Linn Amaranthus spinosus Linn Analgesic Acetic acid induced writhings

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Anti-diabetic and anti-cholesterolemic activity of methanol extracts of three species of Amaranthus

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Asian Pacific Journal of Tropical Biomedicine 2011年第2期1卷 133-138页

作者： Girija K Lakshman K Udaya Chandrika Sabhya Sachi Ghosh Divya T Department of Pharmacognosy PES College of Pharmacy

Objective:To investigate the anti-diabetic and anti-cholesterolemic activity of methanol extracts of leaves of Amaranthus caudatus,Amaranthus spinosus and Amaranthus viridis in normal and streptozotocin(STZ) induced diabetic ***:In this study,the anti-diabetic and anti-cholesterolemic activity of methanol extracts of leaves of all three plants was evaluated by using normal and STZ induced diabetic rots at a dose of 200 mg/kg and 400 mg/kg *** for 21 *** glucose levels and body weight were monitored at specific intervals,and different biochemical parameters,serum cholesterol,serum triglyceride,high density lipoprotein, low density lipoprotein and very low density lipoprotein were also assessed in the experimental *** of pancreas was ***:It was found that all the three plants at 400 mg/kg dose showed significant anti-diabetic and anti-cholesterolemic activity(Pspinosus and Amaranthus viridis showed significant anti-diabetic and anti-cholesterolemic activity,which provides the scientific proof for their traditional claims.

关键词： Amaranthus caudatus Amaranthus spinosus Amaranthus viridis Anti-diabetic activity Anti-cholesterolemic activity Methanol extract Biochemical parameter

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