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Initiation of dendritic NMDA spikes co-regulated via distance-dependent and dynamic distribution of the spine number and morphology in neuron dendrites

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Science China(Technological Sciences) 2023年第2期66卷 429-438页

作者： CAO YuWei SHEN Chun QIU Hu GUO WanLin State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Mechanics and Control of Mechanical Structure and Key Laboratory for Intelligent Nano Materials and Devices of the Ministry of Education Institute for Frontier Science and Institute of NanoscienceNanjing University of Aeronautics and AstronauticsNanjing 210016China

Dendritic spines are small membranous protrusions that receive synaptic inputs from other neurons,enabling the initiation of dendritic N-methyl-D-aspartic(NMDA)spikes and somatic action *** learning and memory processes,both the number of spines on a dendrite and the morphology of individual spines are constantly *** individual influence of spine number and morphology on dendritic NMDA spikes has already been revealed,but the functional significance of the coregulation of spine number and morphology on NMDA spikes remains ***,we systematically investigated the initiation of local dendritic NMDA spikes by the dynamic distributions of the spine number and morphology on single dendrites in reconstructed neuron *** from the traditional cognition,we found the threshold number of spines required to generate local dendrite NMDA spikes on distal dendrites is fewer than that on proximal ones,because the thinner distal dendrites own higher *** for the spine morphology,the presence of moreα-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid(AMPA)receptors on the spine leads to larger NMDA spikes rather than an increase in the spine dimension ***,we first suggested that a single dendrite containing spines with gradually increasing head diameters away from the soma could generate larger NMDA spikes than that irrational distribution of spine morphology containing spines with decreasing head diameters,which can be compensated by the increasing spine ***,the distance-dependent distribution of spine number and morphology co-regulate the intension of dendritic NMDA *** findings about the threshold for NMDA spikes provide novel insights into the role of the irrational dynamic distribution of the spine number and morphology in senescence and disease processes such as Alzheimer’s disease,schizophrenia,and Parkinson’s disease,which causes abnormal neuron firing.

关键词： dendritic spine spine number spine morphology NMDA spikes memory neurological diseases

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