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Progress in the generation of spinal cord organoids over the past decade and future perspectives

Neural Regeneration Research 2024年第5期19卷 1013-1019页

作者： Gang Zhou Siyuan Pang Yongning Li Jun Gao Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of International Medical Service Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

spinal cord organoids are three-dimensional tissues derived from stem cells that recapitulate the primary morphological and functional characteristics of the spinal cord in vivo.As emerging bioengineering methods have led to the optimization of cell culture protocols,spinal cord organoids technology has made remarkable advancements in the past decade.Our literature search found that current spinal cord organoids do not only dynamically simulate neural tube formation but also exhibit diverse cytoarchitecture along the dorsal-ventral and rostral-caudal axes.Moreover,fused organoids that integrate motor neurons and other regionally specific organoids exhibit intricate neural circuits that allows for functional assessment.These qualities make spinal cord organoids valuable tools for disease modeling,drug screening,and tissue regeneration.By utilizing this emergent technology,researchers have made significant progress in investigating the pathogenesis and potential therapeutic targets of spinal cord diseases.However,at present,spinal cord organoid technology remains in its infancy and has not been widely applied in translational medicine.Establishment of the next generation of spinal cord organoids will depend on good manufacturing practice standards and needs to focus on diverse cell phenotypes and electrophysiological functionality evaluation.

关键词： development organoid-on-a-chip pluripotent stem cells progress spinal cord diseases spinal cord organoids vascularization

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Neck pain and absence of cranial nerve symptom are clues of cervical myelopathy mimicking stroke:Two case reports

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World Journal of Clinical Cases 2022年第32期10卷 11835-11844页

作者： Li-Li Zhou Shi-Guo Zhu Yuan Fang Shi-Shi Huang Jie-Fan Huang Ze-Di Hu Jin-Yu Chen Xiong Zhang Jian-Yong Wang Institute of Geriatric Neurology Department of NeurologyThe Second Affiliated Hospital and Yuying Children’s HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

BACKGROUND Cervical myelopathy is a potential stroke imitator,for which intravenous thrombolysis would be catastrophic.CASE SUMMARY We herein present two cases of cervical myelopathy.The first patient presented with acute onset of right hemiparesis and urinary incontinence,and the second patient presented with sudden-onset right leg monoplegia.The initial diagnoses for both of them were ischemic stroke.However,both of them lacked cranial nerve symptom and suffered neck pain at the beginning of onset.Their cervical spinal cord lesions were finally confirmed by cervical computed tomography.A literature review showed that neck pain and absence of cranial nerve symptom are clues of cervical myelopathy.CONCLUSION The current report and the review remind us to pay more attention to these two clues in suspected stroke patients,especially those within the thrombolytic time window.

关键词： Cervical cord spinal cord diseases Stroke Neck pain Cranial nerves Hematoma,epidural,spinal Neoplasm metastasis Case report

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Diagnosis and clinical manifestations of subacute combined degeneration of the spinal cord: Analysis of 21 cases

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Neural Regeneration Research 2007年第2期2卷 112-116页

作者： Yanhong Shou Caifeng Li Dongsheng Fan Yang Shen Jun Zhang Weizhong Xiao Shuqing Zhao Jinsheng Liu Wei Sui Department of Neurology Third Hospital of Peking University Beijing 100083 China Department of Neurology Panshi Boren Hospital Panshi 130021 Jifin Province China

BACKGROUND： Subacute combined degeneration of the spinal cord is caused by vitamin B12 deficiency and is a kind of degenerative disease owing the characteristics of nervous system diseases. In addition, different patients have variously clinical manifestations and various prognoses after vitamin B12 therapy. OBJECTIVE： To investigate and analyze diagnosis, clinical manifestations and prognosis of subacute combined degeneration of the spinal cord. DESIGN： Case analysis. SETTING： Department of Neurology, the Third Hospital of Peking University. PARTICIPANTS： A total of 21 subacute combined degeneration of the spinal cord patients including 14 males and 7 females aged from 33 to 82 years were selected from Department of Neurology, the Third Hospital of Peking University from January 1999 to December 2005. Duration from onset to final diagnosis lasted for 1.5 - 108 months. All patients had typically clinical manifestations; meanwhile, level of serum vitamin B12 was decreased and/or vitamin B12 therapy was effective. All patients provided the confirmed consent. METHODS： Clinical data of 21 subacute combined degeneration of the spinal cord patients were retrospectively analyzed, while general data and clinical characteristics were recorded at the same time. Levels of blood routine, serum vitamin B12 and homocysteine were measured at the phase of hospitalization. Normal value of serum vitamin B12 was 187 - 1 059 ng/L and normal value of serum homocysteine was 5 - 15μ mol/L. All patients received neuroelectrophysiological examination and 15 patients received MRI examinations of spinal cord. After final diagnosis, patients were given vitamin B12 therapy. And follow-up was performed to investigate the prognosis. MAIN OUTCOME MEASURES：（1） Levels of blood routine, serum vitamin B12 and homocysteine; （2） results of neuroelectrophysiological examination; （3） results of MRI examination of spinal cord; （4） prognosis. RESULTS： Clinical data of 21 patients and follow-up data of 20 patients were involved in the final analysis and

关键词： vitamin B12 deficiency spinal cord diseases diagnosis prognosis

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Profiles of and correlation between objective and subjective outcome assessments following open-door laminoplasty for cervical spondylotic myelopathy

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Chinese Medical Journal 2014年第14期127卷 2659-2663页

作者： Zhou Feifei Zhang Yilong Sun Yu Zhang Fengshan Pan Shengfa Diao Yinze Chen Xin Zhao Yanbin Peking Univ Hosp 3 Dept Orthoped Beijing 100191 Peoples R China

Background Open-door laminoplasty is widely used in the treatment of cervical spondylotic myelopathy （CSM）. This study aimed to investigate the profiles of and correlation between objective and subjective short-term outcome assessments after open-door laminoplasty for CSM. Methods We retrospectively analyzed surgical outcomes in 129 consecutive CSM patients who underwent open-door laminoplasty in Peking University Third Hospital from February 2008 to November 2011. Both objective and subjective assessments were evaluated before surgery, 3 months after surgery, and 1 year after surgery. We then analyzed the profiles of and correlation between objective and subjective short-term outcomes. Results The Modified Japanese Orthopaedic Association （mJOA） score was significantly improved at 3 months （P〈0.01） and 1 year （P〈0.01） after surgery. Bivariate Logistic regression showed that sensory improvement contributed more to the recovery rate than motor function improvement at 3 months after surgery, while motor function contributed more to the recovery rate at 1 year after surgery. On the subjective assessment （the short form （SF）-36）, there was no significant improvement at 3 months after surgery （P〉0.05）, while physical function （PF）, role-physical （RP）, and social function （SF） were notably improved at 1 year after surgery （P〈0.01）. Improved mJOA score correlated with improvements in PF, RP, bodily pain, general health （GH）, vitality （VT）, and SF （P〈0.05） at 3 months after surgery; PF, GH, VT, and SF were associated with improved mJOA scores at 1 year after surgery. Conclusions Patients benefit from surgery by postoperative restitution of neurological function with early recovery of sensory function, followed by a gradual transition to motor function improvement. At the early stage of recovery, improvement in the mJOA score essentially correlated with improvements in the physical domains of the SF-36, while at the later stage, mJOA score improvement was associated with improvements in both mental and physical domains of

关键词： cervical verberae spinal cord diseases patient outcome assessment

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手的症状及体征在颈椎脊髓症的诊断与判断预后中的作用

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西安交通大学学报(医学版) 1987年第2期 199-201页

作者：陈君长牛广山李吾成西安医科大学第二附属医院外科学教研室山西省晋东南地区卫生学校

作者等在临床工作中观察到:颈椎脊髓症患者都有不同的手部异常表现,即所谓“颈髓症的手”。本文对此作了详细介绍,主要包括:手部精细运动功能低下;小指分离现象阳性;手指伸屈10秒试验阳性;手指伸屈与腕关节掌屈背伸异常连动;以及其它体... 详细信息

作者等在临床工作中观察到:颈椎脊髓症患者都有不同的手部异常表现,即所谓“颈髓症的手”。本文对此作了详细介绍,主要包括:手部精细运动功能低下;小指分离现象阳性;手指伸屈10秒试验阳性;手指伸屈与腕关节掌屈背伸异常连动;以及其它体征。“颈髓症的手”是诊断重症颈髓症的重要指标之一,能较客观地反映脊髓症的严重程度,并可做为手术预后判断的依据

关键词： spinal cord diseases surgery operative

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