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Two ligands for a GPCR,proton vs lysolipid

Acta Pharmacologica Sinica 2005年第12期26卷 1435-1441页

作者： Dong-soon IM Laboratory of Pharmacology and Research Institute of Drug Development College of Pharmacy Pusan National University Busan 609-735 Republic of Korea

Recently,two different chemicals have been matched as ligands with the same G-protein-coupled receptor(GPCR).Double-pairing of OGR 1 family GPCRs with pro-ton and lysolipid raises several ***,whether both are the real ligandsfor the ***,whether modulation ofa GPCR by two chemicals could ***,one of the chemicals is ***-sensing not only is a newaction mode of GPCR activation,but also it could be generalized in other *** this review,I’d like to summarize the issue and discuss questions with pharma-cological criteria.

关键词： lysolipid proton G-protein-coupled receptor sphingosylphosphorylcholine lysophosphatidylcholine psychosine

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Effects of ovarian cancer G protein coupled receptor 1 on the proliferation, migration, and adhesion of human ovarian cancer cells

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Chinese Medical Journal 2011年第9期124卷 1327-1332页

作者： REN Juan ZHANG Long Cancer Center First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China

Background OGR1 was found as a G-protein coupled receptor （GPCR） and proton sensor. Our previous studies have found that OGR1 has inhibitory effect on the metastasis of prostate cancer. In order to investigate the roles of OGR1 gene in the biological activities of ovarian cancer, we studied the OGR1 effects on ovarian cancer cells, HEY *** OGR1 gene was transfected into HEY cell, in which endogenous expression is low. OGR1-overxepressed cells and vector-transfected cells were compared in different assays. Western blotting was employed to confirm the high expression level of OGR1. Cell proliferation was determined by MTT assay and cell doubling time assay. Cell migration assay （transwell assay） and cell adhesion assay were performed to determine the migration and adhesion potential of cells. Student＇s t test was employed for statistical *** Proliferation of OGR1-overexpressed cells was significantly reduced （P ＜0.01）; cell migration was significantly inhibited in the OGR1-transfected cells （P ＜0.01）; cell adhesion to extracellular matrix including fibronectin, vitronectin,collagen Ⅰ/Ⅳ was significantly increased （P ＜0.01）.Conclusions OGR1 expression in human ovarian cancer cells significantly inhibited the cell proliferation and migration,but significantly enhanced cell adhesion to the extracellular matrix. It indicated that OGR1 may be a tumor suppressor gene for ovarian cancer.

关键词： ovarian cancer g protein coupled receptor 1 ovarian cancer tumor metastasis sphingosylphosphorylcholine lysophosphatidylcholine

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