检索结果-南通市图书馆

sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis

Acta Pharmacologica Sinica 2006年第10期27卷 1359-1366页

作者： Ha-young LEE~(2,3,4) Eun-ha SHIN~(2,4) Yoe-sik BAE~(2,3,5) ~2Medical Research Center for Cancer Molecular Therapy,College of Medicine,Dong-A University,Busan 602-714,Korea,~3Department of Biochemistry,College of Medicine,Dong-A University,Busan 602-714,Korea Medical Research Center for Cancer Molecular Therapy College of Medicine Dong-A University Busan Korea Department of Biochemistry College of Medicine Dong-A University Busan Korea

Aim:To investigate the effects of sphingosylphosphorylcholine(SPC)on humanmonocyte-derived dendritic cell(DC)***:Human DC were gen-erated from peripheral blood monocytes by culturing them with granulocyte mac-rophage-colony stimulating factor and *** effect of SPC on the DCchemotactic migration was measured by chemotaxis *** signalingevent involved in the SPC-induced DC chemotaxis was investigated with severalinhibitors for specific *** expression of the SPC receptors was examinedby reverse transcription polymerase chain ***:We found that SPCinduced chemotactic migration in immature DC(iDC)and mature DC(mDC).Interms of SPC-induced signaling events,mitogen activated protein kinase activa-tion and Akt activation in iDC and mDC were ***-induced chemotaxiswas mediated by extracellular signal-regulated protein kinase and phosphoino-sitide-3-kinase,but not by calcium in both iDC and *** mDC expressovarian cancer G protein-coupled receptor 1,but not G protein-coupled receptor 4,iDC do not express any of these *** examine the involvement of sphin-gosine-1-phosphate(S1P)receptors,we checked the effect of an S1P receptorantagonist(VPC23019)on SPC-induced DC ***23019 did not affectSPC-induced DC ***:The results suggest that SPC may playa role in regulating DC trafficking during phagocytosis and the T cell-stimulatingphase,and the unique SPC receptor,which is different from SIP receptors,isinvolved in SPC-induced chemotaxis.

关键词： dendritic cells sphingosylphosphorylcho line chemotaxis pertussis toxin-sensitive G protein extracellular signal regulated protein kinase

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：