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Roles of sphincter of oddi motility and serum vasoactive intestinal peptide,gastrin and cholecystokinin octapeptide

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World Journal of Gastroenterology 2014年第16期20卷 4730-4736页

作者： Zhen-Hai Zhang Cheng-Kun Qin Shuo-Dong Wu Jian Xu Xian-Ping Cui Zhi-Yi Wang Guo-Zhe Xian Department of Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shangdong University Departments of Minimally Invasive Surgery and the Second General Surgery Shengjing Hospital of China Medical University

AIM: To investigate roles of sphincter of oddi (SO) motility played in pigment gallbladder stone formation in model of guinea pigs.

关键词： Pigment gallstone sphincter of oddi Manometry Myoelectric activity Guinea pig Vasoactive intestinal peptide Gastrin Cholecystokinin octapeptide

sphincter of oddi hypomotility and its relationship with duodenal-biliary reflux,plasma motilin and serum gastrin

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World Journal of Gastroenterology 2008年第25期14卷 4077-4081页

作者： Zhen-Hai Zhang Shuo-Dong Wu Bing Wang Yang Su Jun-Zhe Jin Jing Kong Hao-Lin Wang Department of Hepatobiliary Surgery Shandong Provincial Hospital Jinan 250021 ShandongProvince China Department of Hepatobiliary The Second Affiliated Hospital China Medical UniversityShenyang 110004 Liaoning Province China Department of Ophthalmology ShandongProvincial Hospital Jinan 250021 Shandong Province China

AIM: To detect whether patients with a T tube after cholecystectomy and choledochotomy have duodenal-biliary reflux by measuring the radioactivity of Tc99m-labeled diethylene triamine penta-acetic acid (DTPA) in the bile and whether the patients with duodenal-biliary reflux have sphincter of oddi hypomotility, by mea-suring the level of plasma and serum gastrin of the patients. Finally to if there is close relationship among sphincter of oddi hypomotility, duodenal-biliary reflux and gastrointestinal peptides. METHODS: Forty-five patients with a T tube after cholecystectomy and choledochotomy were divided into reflux group and control group. The level of plasma and serum gastrin of the patients and of 12 healthy volunteers were measured by radioimmunoas-say. Thirty-four were selected randomly to undergo choledochoscope manometry. sphincter of oddi basal pressure (SOBP), amplitude (SOCA), frequency of con-tractions (SOF), duration of contractions (SOD), duo-denal pressure (DP) and common bile duct pressure (CBDP) were scored and analyzed. RESULTS: Sixteen (35.6%) patients were detected to have duodenal-biliary reflux. SOBP, SOCA and CBDP in the reflux group were much lower than the controlgroup (t = 5.254, 3.438 and 3.527, P sphincter of oddi hypomotility and the decreased level of plasma motilin and serum gastrin. The disorder of gastroin-testinal hormone secretion may result in sphincter of oddi dysfunction. There is a close relationship between sphincter of oddi hyp

关键词： sphincter of oddi Tc99m-labeled diethylenetriamine penta-acetic acid Pressure Motilin Gastrin

Effect of morphine and M-cholinoceptor blocking drugs on human sphincter of oddi during choledochofiberscopy manometry

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Hepatobiliary & Pancreatic Diseases International 2003年第1期2卷 121-125页

作者： Shuo-Dong Wu Jing Kong Wei Wang Qiang Zhang Jun-Zhe Jin the Department of Hepatobiliary, Second Affiliated Hospital, China Medical University, Shenyang 110004, China Department of Hepatobiliary Second Affiliated Hospital China Medical University Shenyang 110004 China.

OBJECTIVE: To evaluate the effects of morphine on the human sphincter of oddi pressure and the antagonism of anticholinergic agents against morphine. METHODS: The action of these drugs on the sphincter of oddi (SO) was evaluated by means of choledochofiberscopy manometry in 40 operated patients with T-tube. The patients were divided randomly into 4 groups: anisodamine, atropine, buscopan, and control. The following data were recorded: duodenal pressure (DP), basal pressure of the sphincter of oddi (BPSO), contractive amplitude of the sphincter of oddi (CASO), contractive frequency of the sphincter of oddi (CFSO), contractive duration of the sphincter of oddi (CDSO), and pressure of the common bile duct (PCBD). Both morphine and anticholinergic agents were given intramuscularly. RESULTS: After injection of 10 mg morphine, BPSO, CASO, CFSO, and PCBD increased significantly. After injection of 15 mg anisodamine or 0.75 mg atropine, CASO, BPSO declined obviously, and after injection of 20 mg buscopan, CASO, BPSO, CFSO declined obviously, but in anisodamine, atropine and buscopan groups, they differed insignificantly. CONCLUSIONS: The results illustrate that SO manometry via choledochofiberscopy is a new method for SO dynamic study. Morphine can increase DP, BPSO, CASO, PCBD, but anisodamine atropine and buscopan can antagonize the effect of morphine.

关键词： biliary manometry via choledochofiberscopy morphine anisodamine atropine buscopan contractive amplitude basal pressure sphincter of oddi

Effects of somatostatin analogues on human sphincter of oddi pressure

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 302-305页

作者： Shuo-Dong Wu, Zhen-Hai Zhang, Jing Kong, Yan-Jun Li, Jun-Zhe Jin, Wei Wang, Dong-Yan Li and Min-Fei Wang Shenyang, China No.2 Department of General Surgery, Second Affilia- ted Hospital, China Medical University, Shenyang 110004, China Department of General Surgery Second Affiliated Hospital China Medical University Shenyang 110004 China. wushuodong@***

BACKGROUND: Somatostatin, a neuropeptide and hor- mone , exists in the biliary tract of several species. The effects of somatostatin and its analogues on the sphincter of oddi motility have been controversial. The aim of this study was to observe the action of stilamin and sandostatin on the sphincter of oddi via choledochofiberscope manometry. METHODS: Twenty patients who had had'T' duct after cholecystectomy and choledochotomy were divided into 2 groups randomly: stilamin and sandostatin. They were subjected to manometry via a choledochofiberscope through the'T' duct tract. The following data recorded in- cluded duodenal pressure (DP), sphincter of oddi basal pressure (SOBP), sphincter of oddi contractive amplitude (SOCA), frequency of the sphincter of oddi (SOF), dura- tion of the sphincter of oddi, and the common bile duct pressure (CBDP). RESULTS: After intravenous administration of stilamin at a dose of 250 μg/h, the mean SOCA increased from 89.18 (26.50) to 128.57(54.21) mmHg (P sphincter of oddi whereas the injection of stilamin at a dose of 500 μg/h inhibits its motility. Intravenous injection of sandosta- tin of 100 μg has no effect on the sphincter of oddi.

关键词： biliary manometry via choledochofiberoscopy sphincter of oddi somatostatin stilamin sandostatin

Choledochoscope manometry about different drugs on the sphincter of oddi

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World Journal of Gastroenterology 2008年第38期14卷 5907-5912页

作者： Jing Kong Shuo-Dong Wu Xiao-Bo Zhang Zhen-Sheng Li Gang Shi Wei Wang Jun-Zhi Chen Department of General Surgery Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China Department of Pediatric Surgery Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China

AIM： To assess the effects of H2-receptor blocking pharmacon, protease inhibitor, and gastro kinetic agents on the human sphincter of oddi （SO） motility by choledochoscope manometry. METHODS： One hundred and seventy-five patients with T tube installed after cholecystectomy and choledochotomy were assessed by choledochoscope manometry. They were randomly assigned into groups of H2-receptor blocking pharmacon, protease inhibitor, and gastro kinetic agents. The sphincter of oddi basal pressure （SOBP）, amplitude （SOCA）, frequency of contractions （SOF）, duodenal pressure （DP）, and common bile duct pressure （CBDP） were scored and analyzed. RESULTS： SOBP and SOCA were significantly decreased after Cimetidine administration, and no statistical difference was seen in the Famotidine group. In the Gabexate mesilate group, SOBP had decreased significantly. In the Ulinastatin group, SOCA decreased when Ulinastatin was given at the rate of 2500 U/min; when Ulinastatin administration was raised to 5000 U/ rain, SOBP, SOF and SOCA all experienced a fall. SOBP and SOCA for Domperidone and SOCA for Mosapride groups all decreased distinctly after administration. CONCLUSION： The regular dosage of Cimetidine showed an inhibitory effect on the motility of SO, while Famotidine had no obvious effects otherwise. Gabnexata mesilate, Ulinastatin and gastro kinetic agents also showed inhibitory effects on the SO motility.

关键词： sphincter of oddi Medicamentum Choledochoscope manometry

Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of oddi

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World Journal of Gastroenterology 2005年第21期11卷 3264-3266页

作者： Attila Pálv(o|¨)lgyi Réka Sári József Németh Annamária Szabolcs István Nagy Péter Hegyi János Lonovics Zoltán Szilvássy First Department of Medicine Faculty of Medicine University of SzegedH-6720 SzegedKorányi fasor 8-10 Hungary Department of Pharmacology Medical University of Pécs H-7643 Pécs Szigeti u. 12 Hungary First Department of Medicine Faculty of Medicine University of Szeged H-6720 Szeged Korányi fasor 8-10 Hungary Department of Pharmacology Medical University of Debrecen H-4032 DebrecenNagyerdei krt.98Hungary

AIM: The sphincter of oddi (SO) plays an important role in delivery of bile into the duodenum. To establish whether vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) were involved in phasic contractile activity of the rabbit SO stimulated by cholecystokinin-octapeptide (CCK-8). METHODS: Isolated SO muscle rings were cleaned of fat and mounted horizontally on two small L-shaped hooks one of which was connected to a force transducer for the measurement of isometric *** experiments were carried out in a thermostatically controlled (37±0.2℃) organ bath (5 mL) containing Krebs *** organ fluid was gassed with 95% O2 and 50 mL/L CO2 to keep the pH at 7.40±0.05. Contractile responses to CCK-8 (1 μmol/L) were evaluated in the presence and absence of NG-nitro-L-arginine (LNNA), an inhibitor of NO synthase (100 μmol/L), and (p-chloro-D-Phe6-Leu17)-VIP (VlPa, 30 μmol/L), a VIP receptor antagonist. RESULTS: CCK-8 stimulated the phasic activity of the SO. NO synthase inhibition increased the frequency and amplitude of contractions with a slight increase in developed tension. Pre-incubation with VlPa also attenuated this CCK-8 effect. The combined application of LNNA and VlPa abolished the phasic activity of the muscle rings with a marked increase in tension in response to CCK-8. CONCLUSION: VIP and NO together contribute to an increase in phasic activity of SO.

关键词： sphincter of oddi CCK VIP NO LNNA

Measuring episodic abdominal pain and disability in suspected sphincter of oddi dysfunction

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World Journal of Gastroenterology 2010年第35期16卷 4416-4421页

作者： Valerie Durkalski Walter Stewart Paulette MacDougall Patrick Mauldin Joseph Romagnuolo Olga Brawman-Minzter Peter Cotton Division of Biostatistics and Epidemiology Medical University of South Carolina Center for Health Research Geisinger Health System Digestive Diseases Center Medical University of South Carolina Department of Pharmacy Medical University of South Carolina Department of Psychiatry Medical University of South Carolina

AIM:To evaluate the reliability of an instrument that measures disability arising from episodic abdominal pain in patients with suspected sphincter of oddi dysfunction(SOD).METHODS:Although several treatments have been utilized to reduce pain and associated disability,measurement tools have not been developed to reliably track *** pilot studies were conducted to assess test-retest reliability of a newly developed instrument,the recurrent abdominal pain intensity and disability(RAPID) *** RAPID score is a 90-d summation of days where productivity for various daily activities is reduced as a result of abdominal pain episodes,and is modeled after the migraine disability assessment instrument used to measure headache-related *** was administered by telephone on 2 consecutive occasions in 2 consenting populations with suspected SOD:a pre-sphincterotomy population(Pilot Ⅰ,n = 55) and a post-sphincterotomy population(Pilot Ⅱ,n = 70).RESULTS:The average RAPID scores for Pilots Ⅰ and Ⅱ were:82 d(median:81.5 d,SD:64 d) and 48 d(median:0 d,SD:91 d),*** concordance between the 2 assessments for both populations was very good:0.81 for the pre-sphincterotomy population and 0.95 for the post-sphincterotomy ***:The described pilot studies suggest that RAPID is a reliable instrument for measuring disability resulting from abdominal pain in suspected SOD patients.

关键词： sphincter of oddi Abdominal pain Disability measurement Reproducibility of results Pain measurement Episodic pain

Effects of orexins on myoelectric activity of sphincter of oddi in fasted rabbits

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Acta Pharmacologica Sinica 2006年第2期27卷 212-216页

作者： Song-tao LI~(2,4) Xiao-wei CHEN~(2,3,4) Hong-mei ZHAO~2 Na LI~2 Jie YAN~2 Zhi-an HU~(2,3,5) ~2 Experimental Center of Basic Medicine and ~3Department of Neurobiology.Third Military Medical University,Chongqing 400038,China Experimental Center of Basic Medicine Third Military Medical University Chongqing 400038 China

Aim:To investigate the effects of peripheral orexins on myoelectric activity of thesphincter of oddi(SO)in fasted rabbits,and carry out a preliminary investigationinto the mechanisms underlying these ***:Myoelectric activity ofSO in fasted rabbits was recorded before and after intravenous or local applicationof *** effects of intravenous atropine on orexin-increased myoelectricactivity of SO were ***:Myoelectric activity of SO was activated byboth intravenous and local injection of orexin-A or *** applica-tion of atropine completely inhibited the excitatory effect of orexins on ***:Peripheral application of orexins can increase myoelectric activity ofSO in fasted rabbits,which is partially associated with the activation of the cholin-ergic pathway.

关键词： sphincter of oddi orexins myoelectric activity spike potential rabbits

Nitroester drug's effects and their antagonistic effects against morphine on human sphincter of oddi motility

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World Journal of Gastroenterology 2005年第15期11卷 2319-2323页

作者： Shuo-DongWu Zhen-HaiZhang Dong-YanLi Jun-ZheJin JingKong ZhongTian WeiWang Min-FeiWang DepartmentofHepatobiliarySurgery theSecondAffiliatedHospitalChinaMedicalUniversityShenyang110004LiaoningProvinceChina

AIM: To evaluate the effects of nitroester drugs on human sphincter of oddi (SO) motility and their antagonistic effects against morphine which shows excitatory effect on oddi's sphincter ***: The effects of these drugs on SO were evaluated by means of choledochofiberoscopy manometry.A total of 67 patients having T-tubes after cholecystectomy and choledochotomy were involved in the study, they were randomly divided into glyceryl trinitrate (GTN) group,isosorbide dinitrate (ISDN) group, pentaerythritol tetranitrate (PTN) group, morphine associated with GTN group, morphine associated with ISDN group and morphine associated with PTN group. Basal pressure of oddi's sphincter (BPOS), amplitude of phasic contractions (SOCA), frequency of phasic contractions (SOF), duration of phasic contractions (SOD), duodenal pressure (DP) and common bile duct pressure (CBDP) were scored and analyzed. Morphine was given intramuscularly while nitroester drugs were applied ***: BPOS and SOCA decreased significantly after administration of ISDN and GTN, BPOS reduced from 10.95±7.49 mmHg to 5.92±4.04 mmHg (P＜0.05) evidently after application of PTN. BPOS increased from 7.37±5.58mmHg to 16.60±13.87 mmHg, SOCA increased from 54.09±38.37 mmHg to 100.70±43.51 mmHg, SOF increased from 7.15±3.20 mmHg to 10.38±2.93 mmHg and CBDP increased 3.75±1.95 mmHg to 10.49±8.21 mmHg (P＜0.01)evidently after injection of morphine. After associated application of ISDN and GTN, the four indications above decreased obviously. As for application associated with PTN,SOCA and SOF decreased separately from 100.64±44.99mmHg to 66.17±35.88 mmHg and from 10.70±2.76 mmHg to 9.04±1.71 mmHg (P＜0.05) ***: The regular dose of GTN, ISDN and PTN showed inhibitory effect on SO motility, morphine showed excitatory effect on SO while GTN, ISDN and PTN could antagonize the effect of morphine. Among the three nitroester drugs, the effect of ISDN on SO was most significant.

关键词： sphincter of oddi Nitroester drugs Glyceryl trinitrate Isosorbide dinitrate Pentaerythritol tetranitrate Morphine Choledochofiberoscopy manometry