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sperm origins and concentration do not impact the clinical outcomes in intracytoplasmic sperm injection cycles

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Asian Journal of Andrology 2018年第5期20卷 454-458页

作者： Cen Yang Ze-Hong Zhou Dan-Ni Zheng Xiao-Fei XU Jin Huang Ying Lian Jie Qiao Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction Technology Beijing 100191 China Key Laboratory of Assisted Reproduction Ministry Of Education Beijing 100191 China

In the present study, we evaluated the impact of sperm origins and concentration on the clinical outcomes of intracytoplasmic sperm injection （ICSI） cycles. A total of 1201 IC51 cycles were retrospectively analyzed for male azoospermia or oligozoospermia between January 2015 and December 2015 in the Peking University Third Hospital. Patients were divided into three groups （Group 1 vs Group 2/3; surgically extracted sperm vs ejaculated sperms）： Group 1 included 343 ICSI cycles and Group 2 analyzed 388 cycles on semen with sperm concentration 〈5 × 10^6 m1-1 （severe oligozoospermia group）. Group 3 included 470 cycles with sperm concentration between 5×10^6 m1-1 and 15 × 10^6 m1-1 （mild oligozoospermia group）. Fertilization rates, clinical pregnancy rates, and live birth rates were analyzed and compared among groups of different semen origins and concentrations on the oocyte retrieval day. Group 2 showed a lower fertilization rate than Group 3 （62.9%± 21.6% vs 66.8% ± 22.1%, P 〈 0.05）. There were no statistically significant differences in clinical pregnancy rate per transfer （51.3%, 46.7%, and 50.0%, respectively）, live birth rate per transfer （44.4%, 40.9%, and 41.4%, respectively）, accumulative live birth rate （58.3%, 51.0%, and 52.1%, respectively）, twin birth rate （18.4%, 10.6%, and 12.6%, respectively）, and birth defects rate （0, 0.3%, and 0.2%, respectively） among three groups. The results of this study indicated that sperm origins and concentration do not imDact the clinical outcomes in ICSI cycles.

关键词： azoospermia clinical outcomes intracytoplasmic sperm injection oligozoospermia sperm concentration

A comparison of conventional and computer-assisted semen analysis.（CRISMAS software） using samples from 166 young Danish men

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Asian Journal of Andrology 2011年第3期13卷 453-458,513页

作者： Anne Vested Cecilia H Ramlau-Hansen Jens P Bonde Ane M Thulstrup Susanne L Kristensen Gunnar Toft Danish Ramazzini Center Department of Occupational Medicine Aarhus University Hospital DK-8000 Aarhus C Denmark Department of Occupational and Environmental Medicine Copenhagen University Hospital Bispebjerg DK-2400 Copenhagen NV Denmark

The aim of the present study was to compare assessments of sperm concentration and sperm motility analysed by conventional semen analysis with those obtained by computer-assisted semen analysis （CASA）（Copenhagen Rigshospitalet Image House sperm Motility Analysis System （CRISMAS） 4.6 software） using semen samples from 166 young Danish men. The CRISMAS software identifies sperm concentration and classifies spermatozoa into three motility categories. To enable comparison of the two methods, the four motility stages obtained by conventional semen analysis were, based on their velocity classifications, divided into three stages, comparable to the three CRISMAS motility categories： rapidly progressive （A）, slowly progressive （B） and non-progressive （C＋ D）. Differences between the two methods were large for all investigated parameters （P〈0.001）. CRISMAS overestimated sperm concentration and the proportion of rapidly progressive spermatozoa and, consequently, underestimated the percentages of slowly progressive and non-progressive spermatozoa, compared to the conventional method. To investigate whether results drifted according to time of semen analysis, results were pooled into quarters according to date of semen analysis. CRISMAS motility results appeared more stable over time compared to the conventional analysis; however, neither method showed any trends. Apparently, CRISMAS CASA results and results from the conventional method were not comparable with respect to sperm concentration and motility analysis. This needs to be accounted for in clinics using this software and in studies of determinants of these semen characteristics.

关键词： computer-assisted semen analysis reproduction semen analysis sperm concentration sperm motility

Practical semen analysis： from A to Z

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Asian Journal of Andrology 2010年第1期12卷 14-20页

作者： Charlene Brazil Center for Health and the Environment University of California Davis CA 95616 USA

Accurate semen analysis is critical for decisions about patient care, as well as for studies addressing overall changes in semen quality, contraceptive efficacy and effects of toxicant exposure. The standardization of semen analysis is very difficult for many reasons, including the use of subjective techniques with no standards for comparison, poor technician training, problems with proficiency testing and a reluctance to change techniques. The World Health Organization （WHO） Semen handbook （2010） offers a vastly improved set of standardized procedures, all at a level of detail that will preclude most misinterpretations. However, there is a limit to what can be learned from words and pictures alone. A WHO- produced DVD that offers complete demonstrations of each technique along with quality assurance standards for motility, morphology and concentration assessments would enhance the effectiveness of the manual. However, neither the manual nor a DVD will help unless there is general acknowledgement of the critical need to standardize techniques and rigorously pursue quality control to ensure that laboratories actually perform techniques ＇according to WHO＇ instead of merely reporting that they have done so. Unless improvements are made, patient results will continue to be compromised and comparison between studies and laboratories will have limited merit.

关键词： andrology laboratory quality assurance semen analysis sperm concentration sperm morphology sperm motility

Current treatment for male infertility:an umbrella review of systematic reviews and meta-analyses

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Asian Journal of Andrology 2024年第6期26卷 645-652页

作者： Jian-Jun Ye Ze-Yu Chen Qi-Hao Wang Xin-Yang Liao Xing-Yuan Wang Chi-Chen Zhang Liang-Ren Liu Qiang Wei Yi-Ge Bao Department of Urology and Institute of Urology West China HospitalSichuan UniversityChengdu 610041China West China School of Medicine Sichuan UniversityChengdu 610041China

This umbrella review aimed to summarize and provide a general evaluation of the effectiveness of current treatments for male infertility and assess the quality of evidence and possible *** umbrella review of systematic reviews and meta-analyses available in PubMed,Web of Science,and Scopus,covering studies published up to October 2023,was *** concentration,morphology,and motility were used as endpoints to evaluate the effectiveness of the *** 2998 studies,18 published meta-analyses were extracted,yielding 90 summary effects on sperm concentration(n=36),sperm morphology(n=26),and sperm motility(n=28)on 28 *** of the meta-analyses were classified as having low methodological quality,whereas 12(66.7%)and 6(33.3%)had high and moderate quality,*** the 90 summary effects,none were rated high-evidence quality,whereas 53.3%(n=48),25.6%(n=23),and 21.1%(n=19)were rated moderate,low,and very low,*** improvements in sperm concentration,morphology,and motility were observed with pharmacological interventions(N-acetyl-cysteine,antioxidant therapy,aromatase inhibitors,selective estrogen receptor modulators,hormones,supplements,and alpha-lipoic acid)and nonpharmacological interventions(varicocele repair and redo varicocelectomy).In addition,vitamin supplementation had no significant positive effects on sperm concentration,motility,or *** for male infertility are increasingly diverse;however,the current evidence is poor because of the limited number of *** well-designed studies on single treatment and high-quality meta-analysis of intertreatment comparisons are recommended.

关键词： male infertility meta-analyses sperm concentration sperm morphology sperm motility systematic review treatments umbrella review

Predictors for partial suppression of spermatogenesis of hormonal male contraception

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Asian Journal of Andrology 2008年第5期10卷 723-730页

作者： Jing-Wen Li Yi-Qun Gu peking Union Medical College Postgraduate School Beijing 100730 China National Research Institute for Family Planning Beijing 100081 China

Aim： To analyze factors influencing the efficacy of hormonal suppression of spermatogenesis for male contraception. Methods： A nested case-control study was conducted, involving 43 subjects, who did not achieve azoospermia or severe oligozoospermia when given monthly injections of 500 mg testosterone undecanoate （TU）, defined as partial suppressors compared with 855 subjects who had suppressed spermatogenesis （complete suppressors）. sperm density, serum testosterone, luteinizing hormone （LH） and follicle stimulating hormone （FSH） concentrations at the baseline and the suppression phase were compared between partial and complete suppressors. Polymorphisms of androgen receptor （AR） and three single nucleotide variants and their haplotypes of FSH receptor （FSHR） genes determined by polymerase chain reaction （PCR） and DNA sequencing technique were compared between 29 partial and 34 complete suppressors. Results： Baseline serum LH level was higher and serum LH as well as FSH level during the suppression phase was less suppressed in partial suppressors. Additionally, in a logistic regression analysis larger testis volume, higher serum FSH concentrations alone, or interaction of serum LH, FSH, testosterone and sperm concentrations were associated with degree of suppression. The distribution of polymorphisms of AR or FSH receptor genes did not differ between partial and complete suppressors. In cases with incomplete FSH suppression （FSH 〉 0.2 IU/L）, the chances of reaching azoospermia were 1.5 times higher in the subjects with more than 22 CAG triplet repeats. Conclusion： Partial suppression of spermatogenesis induced by 500 mg TU monthly injections is weakly influenced by hormonal and clinical features but not polymorphism in AR and FSHR genes.

关键词： male contraception genetic polymorphism androgen receptor CAG repeats follicle stimulating hormone receptor single nucleotide polymorphism sperm concentration

Do Ureaplasma urealyticum infections in the genital tract affect semen quality?

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Asian Journal of Andrology 2006年第5期8卷 562-568页

作者： Yan Wang Cui-Ling Liang Jun-Qing Wu Chen Xu Shi-Xiao Qin Er-Sheng Gao Shanghai Institute of Planned Parenthood Research Fudan University Shanghai 200032 China Department of Epidemiology Shanghai Institute of Planned Parenthood Research Shanghai 200032 China Institute of Population Studies East China Normal University Shanghai 200062 China Department of Histology and Embryology School of Medicine Shanghai Jiaotong University Shanghai 200025 China

Aim： To investigate the relationship between Ureaplasma urealyticum （UU） infection and semen quality. Methods： From 2001 to 2003, 346 eligible patients aged 20-45 years were invited from two hospitals in Shanghai, China, to participate in an investigation which included questionnaires about general and reproductive health, an external genital tract examination, UU culture and semen analysis. Multiple linear regression models were used to examine whether UU had a significant effect on semen quality after adjustment for confounding factors. Results： Findings suggested that UU infection was associated with higher semen viscosity and lower semen pH value. sperm concentration was lower in UU positive subjects than that in UU negative subjects （54.04 × 10^6/mL vs.70.58 × 10^6/mL）. However, UU did not significantly affect other semen quality indexes. Conclusion： UU infection of the male genital tract could negatively influence semen quality.

关键词： Ureaplasma urealyticum semen quality sperm concentration seminal plasma questionnaire infection

Single semen analysis as a predictor of semen quality： clinical and epidemiological implications

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Asian Journal of Andrology 2009年第6期11卷 723-730页

作者： Lars Rylander Boel Wetterstrand Trine B Haugen Gunilla Malm Johan Malm Cathrine Bjorsvik Trine Henrichsen Thomas Saether Aleksander Giwercman Reproductive Medicine Centre Maltao University Hospital Lund University Maltao SE-20502 Sweden Division of Occupational and Environmental Medicine Lund University Lund SE-22185 Sweden Faculty of Health Sciences Oslo University College Oslo NO-O130 Norway Andrology Laboratory Dept of Gynecology and Obstetrics Rikshospitalet University Hospital Oslo N0-0027 Norway Department of Clinical Chemistry Malmo University Hospital Malmo SE-20502 Sweden Department of Molecular Biosciences University of Oslo Oslo N0-0316 Norway

It is generally thought that a single ejaculate is a bad predictor of semen quality of a subject, because of significant intra-individual variation. Therefore, we investigated the degree to which the results of a first semen analysis differ from that of a second analysis among men from a how the two different semen results mirrored the overall general population in Norway. In addition, we analysed semen quality assessment. A total of 199 volunteers participated in the study and delivered two semen samples with an interval of 6 months. The semen parameters were determined according to the World Health Organization （WHO） 1999 guidelines, which were also used to determine whether semen quality was normal or abnormal. In addition, the DNA fragmentation index （DFI） was determined using the sperm Chromatin Structure Assay. The two samples from each individual were very similar with regard to standard semen parameters and DFI （rs： 0.67-0.72）, and there were no significant systematic differences between the two samples. The result of the first sample （normal/abnormal） was highly predictive of the overall conclusion based on the two samples （sperm concentration： in 93% of the cases （95% confidence interval [CI]： 89%-96%）; sperm motility： in 85% of the cases （95% CI： 79%-89%）; overall semen quality： in 85% of the cases （95% CI： 80%-90%）. In epidemiological studies, one ejaculate is a sufficient indicator of semen quality in a group of subjects. In a clinical situation, when the question is whether the semen quality is normal or not, the first ejaculate will, in at least 85% of cases, give a correct overall conclusion.

关键词： DNA fragmentation intra-individual semen quality semen volume sperm concentration sperm motility

Correlation between seminal plasma levocarnitine and semen quality

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Correlation between seminal plasma levocarnitine and semen q...

Association between apparent temperature and semen quality:a longitudinal study of Chinese sperm donors

第十五届全国泌尿外科学术会议

作者： Tang Lingfeng, Zhao Lianming, Bai Quan, Hong Kai, Yuan Renpei, Chen Qian, Ma Lulin, Jiang Hui 北京大学第三医院泌尿外科

Objective: To evaluate the relationship between seminal plasma levocarnitine and sperm motility as well as sperm concentration. Methods: 64 infertile men which were divided into four groups (normozoospermia, n = 12, oligozoospermia, n = 16, asthenozoospermia, n = 20, oligoasthenozoospermia, n=16) based on the results of routine sperm test were enrolled in the study. The semen quality was determined by

关键词： levocarnitine male infertility sperm concentration motility

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Association between apparent temperature and semen quality:a...