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Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antivirai platform

Journal of Molecular Cell Biology 2014年第4期8卷 324-337页

作者： Yun-Jia Ning Manli Wang Maping Deng Shu Shen Wei Liu Wu-Chun Cao Fei Deng Yan-Yi Wang Zhihong Hu Hualin Wang State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 China

For antiviral signaling mediated by retinoic acid-inducible gene I （RiG-I）-like receptors （RLRs）, the recruitment of cytosoUc RLRs and downstream molecules （such as TBK1 and IKKε） to mitochondriaL platform is a central event that facilitates the establishment of host antiviral state. Here, we present an example of viral targeting for immune evasion through spatial isolation of TBK1/IKKε from mitochond riai antiviral platform, which was employed by severe fever with thrombocytopenia syndrome virus （SFTSV）, a deadly bunyavirus emerging recently. We showed that SFTSV nonstructural protein NSs functions as the interferon （IFN） antagonist, mainly via suppressing TBK1/IKKε-IRF3 signaling. NSs mediates the formation of cytoplasmic inclusion bodies （IBs）, and the blockage of IB formation impairs IFN-inhibiting activity of NSs. We next demonstrate that I Bs are utilized to compartmentalize TBK1/I KKε. The compartmentalization results in spatial isolation of the kinases from mitochondria, and deprived TBK1/IKKε may participate in antiviral complex assembly, leadingto the blockage of lFN ind uction. This study proposes a new role of viral I Bs as virus-built＇jail＇ for imprisoning cellular factors and presents a novel and likely common mechanism of viral immune evasion through spatial isolation of critical signaling molecules from the mitochondrial antiviral platform.

关键词： innate immunity immune evasion severe fever with thrombocytopenia syndrome virus inclusion bodies TBK1/IKKε spatial isolation

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Temporal and spatial differentiation in microhabitat use: Implications for reproductive isolation and ecological niche specification

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Integrative Zoology 2016年第5期11卷 375-387页

作者： Amaël BORZÉE Jun Young KIM Marina Andrade Martins DA CUNHA Donggeun Lee Eunchong SIN Sunmin OH Yoonjung YI Yikweon JANG Department of Life Sciences and Division of EcoScience Ewha Womans UniversitySeoulKorea Interdisciplinary Program of EcoCreative Ewha Womans UniversitySeoulKorea School of Biological Sciences Seoul National UniversityKorea

Niche differentiation enables ecologically similar species to coexist by lessening competition over food and/or shelters and may be critical for reproductive isolation between closely related species in close ***cause no extra traits need to evolve,spatial and temporal differentiation may readily take place to complement other isolating *** closely related treefrog species occur together in Korea:the endangered Hyla suweonensis and the widespread Hyla *** calls are differentiated,but it is unclear whether call difference is sufficient for reproductive *** tracked individuals of both species to study fine-scale differentiation in microhabitat use in the diel cycle of the breeding season using a harmonic direction *** male movement patterns of both species revealed spatial and temporal differentiation in microhabitat use for calling and resting during the breeding *** of both *** and *** occurred in all 5 microhabitats identified in this study:rice paddy,ground,buried,grass and *** treefrog species showed general similarities in calling from rice paddies and resting in grass and ***,*** moved into rice paddies and produced advertisement calls 3 h earlier than *** differences likely minimize contact between the species and provide an additional isolating *** addition,the activity of *** may be contributing to the decline of this species,as resting in grass would increase dangers from predatory birds and habitat disturbance.

关键词： harmonic direction finding hylid treefrog pre-mating isolation mechanisms spatial isolation temporal isolation

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Spatiotemporal isolation Based Super-Resolution Microscopy

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Chinese Journal of Chemistry 2023年第13期41卷 1608-1623页

作者： Yuxian Lu Pinlong Zhao Jiandong Feng Research Center for Quantum Sensing Research Institute of Intelligent SensingZhejiang LabHangzhouZhejiang311121 China Laboratory of Experimental Physical Biology Department of ChemistryZhejiang UniversityHangzhouZhejiang310027 China

Super-resolution microscopy(SRM)is a powerful imaging technique that overcomes the diffraction limit and allows imaging of the object structure in the ***,SRM suffers from a tradeoff between spatial and temporal resolution,which prevents further exploration in scientific *** this review,we mainly focus on the development of improving spatiotemporal resolution of SRM,including 1)SRM based on physical and computational principles,2)physical and computational factors affecting SRM,from which we conclude some strategies for developing new types of SRM,3)the summary of the various types of SRM based on physical and computational principles,as well as,the analysis of the ordinary and developing *** SRMs based on physical principles and computational principles can be realized with spatial isolation and temporal isolation *** expect this review will offer some new ideas to improve the spatial and temporal resolution simultaneously,which may lead to more new discoveries in biology,chemistry,and materials science.

关键词： Super-resolution imaging Fluorescence Luminescence spatial isolation Temporal isolation

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Soil microbial community diversity and driving mechanisms

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Progress in Natural Science:Materials International 2001年第11期 20-26页

作者：夏北成 D.S.TREVES 周集中 J.M.TIEDJE Center for Microbial Ecology China East Lansing Environmental Science Division Guangzhou 510275 Institute of Environmental Science MI 48824 Michigan State University Oak Ridge National Laboratory TN 38831 USA Zhongshan University

To study the structure of soil microbial communities, DNA was extracted from different environmental soil samples, and 16S rDNA clone libraries were constructed. The diversity of these 16S libraries were analyzed with restriction fragment length polymorphism based on amplification ribosomal DNA restriction analysis ( RFLP-ARDRA) method. The results reveal a high diversity of the soil microbial communities, and striking differences in community structure at different depths. In the surface soil environment, there is no dominant gene pattern, but in the subsurface samples some dominant gene patterns are much more common. With the increasing depth the preference dominance becomes more significant. A spatial isolation hypothesis is proposed to explain the different community structures at different soil depths. Microcosms are set to simulate competition between populations at different degrees of spatial isolation. These studies reveal that spatial isolation caused by low moisture affects the competitive in

关键词： soil microbe cloning community spatial isolation 16S rDNA.

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空间隔离视角下中西方城市社会排斥研究述评

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地理 2021年第2期

作者：韩勇贺萌琳高军波郑茜

空间已成为社会排斥研究的重要维度。本文通过梳理国内外相关文献，重点对空间隔离与社会排斥的内在逻辑及其重点研究领域进行阐述。总体上，社会排斥研究的空间维度聚焦于资源和机会的非均衡配置及流动性障碍导致的边缘化过程。具体来... 详细信息

空间已成为社会排斥研究的重要维度。本文通过梳理国内外相关文献，重点对空间隔离与社会排斥的内在逻辑及其重点研究领域进行阐述。总体上，社会排斥研究的空间维度聚焦于资源和机会的非均衡配置及流动性障碍导致的边缘化过程。具体来讲，从邻里结构性特征中辨识潜在的被排斥主体，强调了社会排斥产生的物质基础；厘清不同尺度、不同空间类型下空间隔离与社会排斥相互作用机制，为消除空间隔离产生的社会排斥障碍提供实践基础。基于社会融合发展目标，提出融贯社会空间隔离到社会空间融合的分析框架，为建构多尺度社会融合路径提供理论支持。

关键词：空间隔离社会排斥城市 spatial isolation social exclusion urban area

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