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The Effect of Peony and Licorice Decoction on the Voltage-Gated Sodium Channel Subtype 1.4 Based on Standard Decoction

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World Journal of Traditional Chinese Medicine 2018年第2期4卷 69-76页

作者： Guang-Wei Zhu Jie Guo Ya-Jing Li Lu Luo Toru Sugita Takehisa Tomoda Research Center for Quality Standard China Academy of Chinese Medicinal SciencesInstitute of Chinese Materia MedicaSchool of Traditional Chinese Materia Medica Research Center for Quality Standard Shandong University of Traditional Chinese Medicine QC center of TCM China Academy of Chinese Medicinal SciencesInstitute of Acupuncture and Moxibustion Research Center for Quality Standard TSMUURA and Co.

Objective:The objective of this study is to investigate the inhibitory effect of peony and licorice decoction and its compatibility components on the Nav1.4 voltage-gated sodium channels(VGSCs).Materials and Methods:Writhing test was carried out with ICR *** lactiflora and Glycyrrhiza uralensis group were administrated 0.2 ml of solution of freeze-dried powder dissolved in normal saline with the concentration of 2.94 mg/ml,1.47 mg/ml,and 0.74 mg/ml using intragastric administration,*** and licorice decoction groups were administrated 0.2 ml of solution of freeze-dried powder dissolved in normal saline with the concentration of 5.89 mg/ml,2.94 mg/ml,and 1.47 mg/ml using intragastric administration,*** electrophysiology studies,each freeze-dried powder was dissolved in DMSO to make 10 mg/ml and 50 mg/ml stock *** electrophysiological recordings were obtained under visual control of a *** UPLC analysis,the freeze-dried powder was dissolved in methanol and then determines the contents of the nine marker ***:The effect of *** on incubation period and writhing frequency was significantly better than that of peony and licorice decoction group and *** *** inhibition rate of 50 mg/ml water extracts of the three samples was significantly higher than that of the 10 mg/ml ***,the water extract of *** at 50 mg/ml had the strongest inhibitory effect on I_(Nav) 1.4 of the ***:The possible mechanism of peony and licorice decoction in relieving spasm and pain is most likely by inhibiting Voltage-Gated Sodium Channel Subtype 1.4.

关键词： Nav1.4 voltage-gated sodium channels Paeonia lactiflora and Glycyrrhiza uralensis peony and licorice decoction spasm and pain relieving standard decoction

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