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Application of the somatosensory Interaction Technology Combined with Virtual Reality Technology on Upper Limbs Function in Cerebrovascular Disease Patients

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Journal of Biomedical Science and Engineering 2020年第5期13卷 66-73页

作者： Wangxiang Mai Liang Fang Zhuoming Chen Xiuping Wang Wanting Li Weiyi He Department of Rehabilitation Medicine The First Affiliated Hospital of Jinan University Guangzhou China Haizhu District Hospital of Traditional Chinese Medicine Guangzhou China Department of Pediatrics The First Affiliated Hospital of Jinan University Guangzhou China.

Objective: To explore the effects of the somatosensory interaction technology combined with virtual reality technology on upper limbs function and activities of daily living (ADL) in cerebrovascular disease patients. Methods: Form January, 2019 to December, 2019, 80 cerebrovascular disease patients were recruited, and had been divided into control group (n = 40) and observation group (n = 40), randomly. The control groups received conventional rehabilitation treatment, for 40 minutes per day, while observation group received conventional rehabilitation treatment, for 20 minutes per day, and virtual reality technology treatment, 20 minutes per day, 5 days a week for 4 weeks. Wolf Motor Function Test (WMFT), Fugl-Meyer Assessment-Upper Extremities (FMA-UE) and modified Barthel index (MBI) were used to assess the motor function of the upper limbs and ADL before and after treatment. Results: Before treatment, the scores of WMFT, FMA-UE and MBI were no significant difference between two groups (P > 0.05). The scores improved in both groups after treatment (P somatosensory interaction technology combined with virtual reality technology could facilitate to improve the upper limbs function and ADL in cerebrovascular disease patients.

关键词： Cerebrovascular Disease somatosensory Interaction Virtual Reality Upper Limbs Function Rehabilitation

Using Variations of somatosensory Evoked Potentials to Quantify Spinal Cord Injury Level

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Engineering（科研） 2013年第10期5卷 99-102页

作者： Hasan Mir Hasan Al-Nashash Douglas Kerr Angelo All Nitish Thakor Department of Electrical Engineering American University of Sharjah Sharjah UAE Department of Neurology Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore USA

Existing work indicates that the degree of variation of somatosensory evoked potential (SEP) signals between a healthy spinal pathway and spinal pathway affected by spinal cord injury (SCI) can be used to evaluate the integrity of the spinal pathway. This paper develops a metric that exploits the time-domain features of SEP signals (relative amplitude, time scaling, and time duration) in order to quantify the level of SCI. The proposed method is tested on actual SEP signals collected from rodents afflicted with focal demyelination SCI. Results indicate that the proposed method provides a robust assessment of the different degrees of demyelination in the spinal cord.

关键词： somatosensory Evoked Potential (SEP) Spinal Cord Injury (SCI) Signal Morphology

Changes　of　somatosensory　evoked　potentials　and　sciatic　nerve　conductivity　in　chronic　renal　failure　in　rats

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Journal of Medical Colleges of PLA(China) 1996年第1期11卷 41-44页

作者：光丽霞袁发焕廖立生杨晓霞王东武赵士福郑健

Somatasensory evoked potentials (SEP), sciatic nerve conduction velocity (CV), sciatic nerve Na+-K+-ATPase activity, and lipid peroxide content (LPO) were determined in 8 rats with chronic renal failure induced with 5/6 nephrectomy. Meanwhile, the histological changes were also oserved. Ten rats wtih sham operation served as the control. It was found that in the group with chronic renal failure, the mean peak latency of SEP was significantly prolonged and CV slower than those of the control. In the sciatic nerve tissue, Na+-K+-ATPase activity was loyer and LPO content higher in the tested group than in the control. No significant histological changes of the sciatic nerve were found under optical microscope. These findings suggest that the decrease of nerve conductivity after chronic renal failure might result from the insufficient activity of Na+-K+-ATPase and enhanced generation of free oxygen radicals.

关键词： renal failure chronic somatosensory evoked potential nerve conduction Na￣+-K￣+-ATPase rats

Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico I.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of Excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA Institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia Department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of Excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

FUNCTIONAL MAPPING OF THE HUMAN BRAIN DURING ACUPUNCTURE WITH MAGNETIC RESONANCE IMAGINGsomatosensory CORTEX ACTIVATION

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World Journal of Acupuncture-Moxibustion 1997年第3期7卷 44-49页

作者：许健生刘京邝健民

Hegu (LI 4) is one of the most frequently used and most important analgesic points in Chinese acupuncture. It is particularly effective for treating disorders of the head and face. According to the meridian theory in Traditional Chinese Medicine (TCM), the Large Intestine Meridian to which it belongs originates in the hand and terminates in the face. This theory is based, however, more on thousands of years of clinical experience rather than on scientific evidence. In our study of acupuncture effects on normal human volunteers with the non-invasive BOLD (blood oxygenation level dependant)technique for FMRI (functional magnetic resonance imaging), we demonstrated widespread effects in the brain during acupuncture at Hegu and Zusanli (ST 36). A finding of special interest was observed in the primary somatosensory cortes (SI) during Hegu acupuncture. In additlon to activation of the area representing the hand in response to the sensory impulses arising from the site of stimulation, activation also occurred in the face representation in all 3 subjects brains studied by coronal brain sections. In one of these subjects activation in the face representation was even stronger than that in the hand representation. Areas representing the neck, trunk and other parts of the upper extremity also exhibited increase in signal intensity, subject to individual variability. As compared with Hegu, such effects were either absent or much weaker with acupuncture at Zusanli (ST 36) or with other forms of sensory stimulation to the hand. Functional mapping of the brain with MRI has provided the first direct evidence in support of the important role of Hegu acupuncture in TCM.

关键词： FMRI Human brain Hegu(LI 4) Acupuncture somatosensory cortex activation Face representation

Morphological properties of nociceptive and non-nociceptive neurons in primary somatic cerebral cortex (SI) of cat

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Chinese Science Bulletin 2000年第22期45卷 2029-2034页

作者： Rihui Zhang Guoxi Teng China Med Univ Neurophysiol Lab Inst Brain Res Shenyang 110001 Peoples R China

With the techniques of intracellular recording and labelling, we investigated pain sensation and modulation of the somatic cortical cortex at the neuron’s level. After observing the evoked potentials from stimulating the saphenous nerves (SN) of 654 neurons in SI area of the cats, we labelled 30 of the neurons with Neurobiotin to preserve the distribution and the morphologic characteristics of the neurons in the cortex. Based on the tridimensional reconstruction in addition to the eletrophysiological functions, we found clear morphological distinctions between nociceptive and non-nociceptive neurons (Psomatosensory cortex (SI) and presented further evidence to support the 'specificity theory' of pain sensation in terms of morphology.

关键词： somatosensory cortex pain sensation intracellular recording intracellular labelling immunohisto-chemistry.

Functional dissection of parabrachial substrates in processing nociceptive information

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Zoological Research 2024年第3期45卷 633-647页

作者： Jin Ke Wei-Cheng Lu Hai-Yang Jing Shen Qian Sun-Wook Moon Guang-Fu Cui Wei-Xin Qian Xiao-Jing Che Qian Zhang Shi-Shi Lai Ling Zhang Ying-Jie Zhu Jing-Dun Xie Tian-Wen Huang Shenzhen Key Laboratory of Drug Addiction Shenzhen-Hong Kong Institute of Brain ScienceBrain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Anesthesiology State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China University of Science and Technology of China HefeiAnhui 230027China Department of Anesthesiology Shenzhen University General Hospital and Shenzhen University Academy of Clinical Medical SciencesShenzhen UniversityShenzhenGuangdong 518055China School of Medicine Yunnan UniversityKunmingYunnan 650091China

Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of *** lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity ***,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain *** this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such ***,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external ***,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive *** results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions.

关键词： Lateral parabrachial nucleus Substance P receptor Pain affect Defensive reaction somatosensory

Effect of Paired Associative Stimulation on Motor Cortex Excitability in Rats

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Current Medical Science 2018年第5期38卷 903-909页

作者： Xiang-yu ZHANG Yan-fang SUI Tie-cheng GUO Sai-hua WANG Yan HU Yin-shan LU Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Rehabilitation Medicine the 5th Hospital of Zhengzhou UniversityZhengzhou 470000China Department of Rehabilitation Medicine the 1st People's Hospital of HaikouHaikou 570208China Department of Rehabilitation Medicine the 1st Hospital of WuhanWuhan 430022China Department of Rehabilitation Medicine Zhongnan HospitalWuhan UniversityWuhan 430071China

Paired associative stimulation (PAS),combining transcranial magnetic stimulation (TMS) with electrical peripheral nerve stimulation (PNS) in pairs with an optimal interstimulus interval (ISI)in between,has been shown to influence the excitability of the motor cortex (MC)in ***,the underlying mechanisms remain *** study was designed to explore an optimal protocol of PAS,which can modulate the excitability of MC in rats,and to investigate the underlying mechanisms. The resting motor thresholds (RMTs) of TMS-elicited motor evoked potentials (MEPs) recorded from the gastrocnemius muscle and the latency of P1 component of somatosensory evoked potentials (SEPs) induced by electrical tibial nerve stimulation were determined in male Sprague-Dawley rats (n=10).Sixty rats were then randomly divided into 3 groups:a PAS group (further divided into 10 subgroups at various ISIs calculated by using the latency of P1,n=5,respectively),a TMS (only)group (n=5)and a PNS (only)group (n=5).Ninety repetitions of PAS,TMS and PNS were administered to the rats in the 3 groups,respectively,at the frequency of 0.05 Hz and the intensity of TMS at 120% RMT and that of PNS at 6 *** and motor evoked potentials'amplitude (MEPamp)were recorded before and immediately after the *** was found that the MEPamp significantly decreased after PAS at ISI of 5 ms (P0.05).PAS at other ISis as well as the sole use of TMS and PNS induced no remarkable changes in MEPamp and *** conclusion,PAS can influence motor cortex excitability in *** TMS alone nor PNS alone shows significant effect.

关键词： paired associative stimulation transcranial magnetic stimulation peripheral nerves electrical stimulation resting motor thresholds motor evoked potentials somatosensory evoked potentials

Prevention effect of medical self-crosslinking sodium hyaluronate gel on epidural scar adhesion after laminectomy

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Asian Pacific Journal of Tropical Medicine 2014年第6期7卷 501-504页

作者： Hua Liu Hai-Feng Li Jian-Yuan Wang Orthopaedic Department of PLA 474 Hospital Spinal Surgery Department of of First Affiliated Hospital of Xinjiang University

Objective:To analyze the effect and medical sclf-crosslinking sodium hyaluronate gel on epidural scar adhesion after ***:A total of 24 New Zealand L5 laminectomy rabbits were randomly divided into four groups,group A as the control group without any treatment:group B covered by sodium hyaluronate gel;group C and group D covered by 0.5 and1.0 mL medical self-crosslinking sodium hyaluronate *** rabbits were scored at various time points after 2.4,6,8,12 weeks,then the formation of scar was ***:In Groups B,C,D loose scar tissue occurred after 2 weeks of the operation,scar tissues were significantly less than that in group A,with mild inflammatory *** 8 weeks,the scar tissues of group B were significantly more than that of groups C,*** two weeks,group B,C were back to the preoperative level;After 4 weeks,group D was back to the preoperative level;After four weeks,the CSEP of group A was increased significantly,which was significantly higher than that in groups B,C,*** motor function score of group A,group B and group C were the same as preoperative,but that in group D it was decreased significantly,and then it gradually *** 4 weeks it kept a stable *** motor function score of group A was decreased gradually after the operation,which kept a stable level after 4 weeks,the motor function score was significantly lower man that in groups B,C,***:Determination of somatosensory evoked potentials is sensitive indicator of spinal cord injury;Application of medical selfcrosslinking sodium hyaluronate gel is effective on epidural scar adhesion after laminectomy.

关键词： Animal Hyaluronic acid Laminectomy Induced potentials somatosensory