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somatic growth of lean children:the potential role of sleep

World Journal of Pediatrics 2014年第3期10卷 245-250页

作者： Yan-Rui Jiang Karen Spruyt Wen-Juan Chen Xiao-Ming Shen Fan Jiang Department of Developmental and Behavioral Pediatrics Shanghai Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina and MOE-Shanghai Key Laboratory of Children's Environmental Health Shanghai Institute for Pediatric Research Xinhua HospitalShanghai Jiaotong University School of Medicine and MOE-Shanghai Key Laboratory of Children's Environmental HealthShanghaiChina

Background:Despite the current obesity pandemic,childhood malnutrition remains an urgent,public health *** to the obesity pandemic,childhood malnutrition is influenced by genetic and a number of social,environmental and biological *** this study,we investigated the association between sleep duration and somatic growth in lean ***:A stratified,randomly clustered sampling design was used to select fifth grade students from 10 primary schools in *** on a body mass index below the 15th percentile a subsample of 143 lean children aged 10-11 years old was defi *** duration and other potential confounders were surveyed through parental or self-report *** measurements were collected and used to calculate the Z score of weight,height,body mass index as well as body fat ***:Compared with children who slept<9 hours,those who slept for≥10 hours grew taller and gained more weight after adjusting for confounding *** children slept 9-10 hours,they had signifi cantly higher Z score of weight and body mass ***:Prolonged sleep not only benefi ts weight gain but also improves height in lean *** findings might provide important public health advice such that prolonged sleep may be an effective modifi er of nutritional problems in childhood.

关键词： height lean children sleep somatic growth weight

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The key role of myostatin b in somatic growth in fishes derived from distant hybridization

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Science China(Life Sciences) 2024年第7期67卷 1441-1454页

作者： Qingfeng Liu Lujiao Duan Bei Li Xuanyi Zhang Fanglei Liu Jianming Yu Yuqin Shu Fangzhou Hu Jingjing Lin Xiaoxia Xiong Shaojun Liu State Key Laboratory of Developmental Biology of Freshwater Fish Hunan Normal UniversityChangsha 410081China College of Life Sciences Hunan Normal UniversityChangsha 410081China

The basic mechanism of heterosis has not been systematically and completely *** previous studies,we obtained three economically important fishes that exhibit rapid growth,WR(WCC♀×RCC♂),WR-Ⅱ(WR♀×WCC♂),and WR-Ⅲ(WR-Ⅱ♀×4nAU♂),through distant ***,the mechanism underlying this rapid growth remains *** this study,we found that WR,WR-Ⅱ,and WR-Ⅲshowed muscle hypertrophy and higher muscle protein and fat contents compared with their parent species(RCC and WCC).Candidate genes responsible for this rapid growth were then obtained through an analysis of 12 muscle ***,the mRNA level of mstnb(myostatin b),which is a negative regulator of myogenesis,was significantly reduced in WR,WR-Ⅱ,and WR-Ⅲcompared with the parent *** verify the function of mstnb,a mstnb-deficient mutant RCC line was generated using the CRISPR-Cas9 *** average body weight of mstnb-deficient RCC at 12 months of age was significantly increased by 29.57%compared with that in wild-type ***,the area and number of muscle fibers were significantly increased in mstnb-deficient RCC,indicating hypertrophy and ***,the muscle protein and fat contents were significantly increased in mstnb-deficient *** molecular regulatory mechanism of mstnb was then revealed by transcription profiling,which showed that genes related to myogenesis(myod,myog,and myf5),protein synthesis(PI3K-AKT-mTOR),and lipogenesis(pparγand fabp3)were highly activated in hybrid fishes and mstnb-deficient *** study revealed that low expression or deficiency of mstnb regulates somatic growth by promoting myogenesis,protein synthesis,and lipogenesis in hybrid fishes and mstnb-deficient RCC,which provides evidence for the molecular mechanism of heterosis via distant hybridization.

关键词： distant hybridization heterosis somatic growth myostatin b genome editing

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Neuroendocrine regulation of somatic growth in fishes

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Science China(Life Sciences) 2015年第2期58卷 137-147页

作者： DAI XiangYan ZHANG Wei ZHUO ZiJian HE JiangYan YIN Zhan Key Laboratory of Aquatic Biodiversity and Conservation of the Chinese Academy of Sciences Institute of Hydrobiology Chinese Academy of Sciences University of Chinese Academy of Sciences

growth is a polygenic trait that is under the influence of multiple physiological pathways regulating energy metabolism and muscle *** the possible growth-regulating pathways in vertebrates,components of the somatotropic axis are thought to have the greatest *** is growing body of literature focusing on the somatotropic axis and its role regulating growth in *** includes research into growth hormone,upstream hypothalamic hormones,insulin-like growth factors,and downstream signaling *** of these signals have both somatic effects stimulating the growth of tissues and metabolic effects that play a role in nutrient *** of other endocrine axes exhibit profound effects on the function of the somatotropic axis in *** this review we highlight recent advances in our understanding of the teleost fish endocrine somatotropic axis,including emerging research using genetic modified *** studies have revealed new aspects and challenges associated with regulation of the important steps of somatic growth.

关键词： somatic growth endocrine regulation fish

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Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity

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Journal of Molecular Cell Biology 2020年第4期12卷 291-304页

作者： Chuang Shi Yao Lu Gang Zhai Jianfei Huang Guohui Shang Qiyong Lou Dongliang Li Xia Jin Jiangyan He Zhenyu Du Jianfang Gui Zhan Yin State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China School of Life Sciences East China Normal UniversityShanghai 200241China The Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100864China

The endocrine regulatory roles of the hypothalamic-pituitary-adrenocortical axis on anxiety-like behavior and metabolic status have been found throughout animal ***,the precise effects of the balancing adrenal corticosteroid biosynthesis under the influence of adrenocorticotrophic hormone(ACTH),a pro-opiomelanocortin(POMC)-derived peptide,on animal energy expenditure and somatic growth remain *** has also been identified as one of the candidate loci for polycystic ovary syndrome,which features hyperandrogenism and some prevalence of obesity in *** we show that zebrafish lacking functional POMCa exhibit similar phenotypes of stress response and body weight gain but not obesity as observed in mammalian *** contrast with the impaired anorexigenic signaling cascade of melanocyte-stimulating hormones and leptin,which are responsible for their obesity-prone weight gain observed in various pome mutant mammals,analyses with our pomca mutant series indicate that ACTH is the key regulator for the phenotype with enhanced somatic growth without obesity in pomca-deficient *** associated with hyperandrogenism has been observed in the pomca-deficient zebrafish,with enhanced activation of mammalian target of rapamycin complex 1;reutilization of amino acids and fatty acid^-oxidation are observed in the muscle tissue of the pomca-deficient *** reducing hyperandrogenism by crossing our pomca mutant fish with a cy p l 7a 1-deficient background,the phenotype of enhanced somatic growth in pomca-deficient fish was no longer ***,our work also demonstrated that the role of POMCa in stress response seems to be conserved in vertebrates,whereas its effect on adipostasis is unique to teleosts.

关键词： anabolic metabolism HPI axis pomca somatic growth stress response

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