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Relationship among soluble cd105, hypersensitive C-reactive protein and coronary plaque morphology： an intravascular ultrasound study

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Chinese Medical Journal 2008年第2期121卷 128-132页

作者： CUI Song Lü Shu-zheng CHEN Yun-dai HE Guo-xiang MENG Li-jun LIU Jian-ping SONG Zhi-yuan LIU Xian-liang SONG Xian-tao GE Chang-jiang LIU Hong Department of Cardiology Anzhen Hospital Affiliated to Capital Medical University Beijing 100029 China Department of Cardiology Southwest Hospital Third Military Medical University Chongqing 400038 China Department of Cardiology Binzhou Central Hospital Binzhou Shandong 251700 China

Background Rupture of unstable plaque with subsequent thrombus formation is the common pathophysiological substrate of acute coronary syndrome （ACS）. It is of potential significance to explore the blood indexes predicting plaque characteristics. We investigated the relationship among soluble cd105, hypersensitive C-reactive protein （hs-CRP）, and coronary plaque morphology.Methods A clinical study from April 2004 to December 2006 was conducted in 130 patients who were divided into 3 groups： 56 patients （43.1%） in stable angina （SA） group, 52 patients （40.0%） in unstable angina （UA） group and 22 patients （16.9%） in acute myocardial infarction group. The concentrations of soluble cd105 and hs-CRP were measured in all of the patients by cardioangiography （CAG）. Plasma samples of arterial blood were collected prior to the procedure. The levels of soluble cd105 and hs-CRP were measured by enzyme-linked immunosorbent assay （ELISA）.Results Unstable and ruptured plaque was found more frequently in patients with acute myocardial infarction and UA. External elastic membrane cross-sectional area （EEM CSA）, plaque area, lipid pool area and plaque burden were significantly larger in the ruptured and unstable plaque group. Positive remodeling, thinner fabric-cap, smaller minimal lumen cross-sectional area （MLA）, dissection and thrombus were significantly more frequent in the ruptured and unstable plaque group. Remodeling index （RI） was positively correlated with the levels of soluble cd105 in the UA group （r=0.628, P〈0.01） and the acute myocardial infarction group （r=0.639, P〈0.01）. The levels of soluble cd105 and hs-CRP were higher in the ruptured plaque group. soluble cd105 〉4.3 ng/ml was used to predict ruptured plaque with a receiver operating characteristic （ROC） curve area of 0.77 （95% confidence interval （CI）, 66.8%-87.2%）, a sensitivity of 72.8%, a specificity of 78.0% and an accuracy of 70.2% （P〈0.01）, similarly for hs-CRP 〉 5.0 mg/ml with a ROC curve area of 0.70 （95

关键词： intravascular ultrasound soluble cd105 neovascularization hypersensitive C-reactive protein

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Relationship between intravascular ultrasound imaging features of coronary plaques and soluble cd105 level in patients with coronary heart disease

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Chinese Medical Journal 2007年第7期120卷 595-597页

作者： CUI Song LUe Shu-zheng CHEN Yun-dai HE Guo-xiang LIU Jian-ping SONG Zhi-yuan SHU Mao-qin HU Hou-yuan RAN Bo-li JING Tao Department of Cardiology Anzhen Hospital Affiliated to Capital Medical University Beijing 100029 China Department of Cardiology Southwest Hospital Third Military University Chongqing 400038 China

Plaque rupture with subsequent thrombus formation is the common pathophysiological substrate of acute coronary syndrome （ACS）. Moreno et al reported mat neovascularization as manifested by the localized appearance of microvessels is increased in ruptured plaques in the human aorta. Microvessel density is also increased in inflammatory lesions, with intraplaque hemorrhage and in thin-cap fibroatheromas. Microvessels at the base of the plaque are independently correlated with plaque rupture, suggesting a contributory role for neovascularization in the process of plaque rupture. soluble cd105, a sensitive serum marker of neovascularization, is thought to be associated with cardiovascular disease. The purpose of this study was to assess the relationship between the level of soluble cd105 and the morphological plaques by intravascular ultrasound （IVUS） in patients with stable angina （SA） and those with unstable angina （UA） and whether soluble cd105 may serve as a non-invasive marker of coronary plaque destabilization.

关键词： intravascular ultrasound soluble cd105 neovascularization angina pectoris

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