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Risk factors of poor prognosis and portal vein tumor thrombosis after curative resection of solitary hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 68-73页

作者： Li Zhou Jing-An Rui Shao-Bin Wang Shu-Guang Chen Qiang Qu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences/Peking Union Medical College

BACKGROUND:Predictors of poor prognosis of solitary hepatocellular carcinoma(SHCC),a subgroup encompassing most patients with the malignancy,are still ***,risk factors for portal vein tumor thrombosis(PVTT) in SHCC are *** present study was designed to address this ***:Clinicopathological and follow-up data for 156 consecutive patients with SHCC following curative hepatic resection were analyzed using uni-and multi-variate ***:Univariate analysis showed that PVTT,tumornode-metastasis(TNM) stage,Edmondson-Steiner grade and preoperative serum alpha-fetoprotein(AFP) level were associated with the overall and disease-free survival,whereas tumor size only influenced the overall *** multivariate Cox regression tests,Edmondson-Steiner grade and TNM stage were independent prognostic markers for both overall and diseasefree *** addition,the Chi-square test showed that AFP level and Edmondson-Steiner grade were correlated with *** them,only Edmondson-Steiner grade was shown to be of independent significance for PVTT in multi-variate logistic regression ***,AFP,the sole preoperative factor for PVTT,was not adequately sensitive and ***:Factors relating to post-surgical prognosis and PVTT in SHCC are all *** these,EdmondsonSteiner grade and TNM stage might be of particular importance in survival *** addition,accurate prediction of PVTT by clinicopathological parameters before surgery remains difficult.

关键词： solitary hepatocellular carcinoma curative resection prognosis portal vein tumor thrombosis

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