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Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss

International Journal of Oral Science 2015年第4期7卷 242-249页

作者： Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani Department of Biochemistry and Molecular Biology Nihon University School of Dentistry at Matsudo Research Institute of Oral Health Nihon University School of Dentistry at Matsudo Department of Oral Health Graduate School of DentistryKanagawa Dental University Department of Dental Hygiene Howon University Department of Preventive and Public Oral Health Nihon University School of Dentistry at Matsudo Department of Anesthesiology Nihon University School of Dentistry at Matsudo Department of Infection Control Division of MicrobiologyKanagawa Dental University Department of Radiopraxis Science Kanagawa Dental University

Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors. Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases. Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride （NaF） on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. NaF strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin （IL）-1β, matrix metalloproteinase 9 （MMP9）, and tartrate-resistant acid phosphatase, which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect, NaF inhibited osteoclast formation caused by the differentiation factor RANKL （receptor activator of nuclear factor KB ligand） and macrophage colony-stimulating factor （M-CSF）. The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells （NFAT） cl was also abrogated by NaF. Taken together, our data demonstrate that NaF inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATcl, ultimately leading to the suppressed expression of cathepsin K and MMP9. The in vivo effect of NaF on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of NaF for treating periodontal diseases.

关键词： alveolar bone loss osteoclasts Porphyromonas gingivalis sodium fluoride

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Bones and Crohn’s:No benefit of adding sodium fluoride or ibandronate to calcium and vitamin D

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World Journal of Gastroenterology 2011年第3期17卷 334-342页

作者： Jochen Klaus Max Reinshagen Katharina Herdt Christoph Schrter Guido Adler Georg BT von Boyen Christian von Tirpitz Department of Internal Medicine I University of Ulm Albert Einstein Allee 23 89081 Ulm Germany Department of Internal Medicine I Stdtisches Klinikum Braunschweig Salzdahlumer Straβe 90 38126 Braunschweig Germany Medizinische Klinik Kreisklinik Biberach Ziegelhausstraβe 50 88400 Biberach Germany

AIM: To compare the effect of calcium and cholecalciferol alone and along with additional sodium fluoride or ibandronate on bone mineral density (BMD) and fractures in patients with Crohn's disease (CD). METHODS: Patients (n =148) with reduced BMD (T-score sodium fluoride (25 mg bid) (group B, n = 62) or additional ibandronate (1 mg iv/3-monthly) (group C, n = 54). Dual energy X-ray absorptiometry of the lumbar spine (L1-L4) and proximal right femur and X-rays of the spine were performed at baseline and after 1.0, 2.25 and 3.5 years. Fracture-assessment included visual reading of X-rays and quantitative morphometry of vertebral bodies (T4-L4).RESULTS: One hundred and twenty three (83.1%) patients completed the first year for intention-to-treat (ITT) analysis. Ninety two (62.2%) patients completed the second year and 71 (47.8%) the third year available for per-protocol (PP) analysis. With a significant increase in T-score of the lumbar spine by +0.28 ± 0.35 [95% conf idence interval (CI): 0.162-0.460, P < 0.01], +0.33 ± 0.49 (95% CI: 0.109-0.558, P < 0.01), +0.43 ± 0.47 (95% CI: 0.147-0.708, P < 0.01) in group A, +0.22 ± 0.33 (95% CI: 0.125-0.321, P < 0.01); +0.47 ± 0.60 (95% CI: 0.262-0.676, P < 0.01), +0.51 ± 0.44 (95% CI: 0.338-0.682, P < 0.01) in group B and +0.22 ± 0.38 (95% CI: 0.111-0.329, P < 0.01), +0.36 ± 0.53 (95% CI: 0.147-0.578, P < 0.01), +0.41 ± 0.48 (95% CI: 0.238-0.576, P < 0.01) in group C, respectively, during the 1.0, 2.25 and 3.5 year periods (PP analysis), no treatment regimen was superior in any in- or between-group analyses. In the ITT analysis, similar results in all in- and between-group analyses with a significant in-group but non-significant between-group increase in T-score of the lumbar spine by 0.38 ± 0.46 (group A, P < 0.01), 0.37 ± 0.50 (group B, P < 0.01) and 0.35 ± 0.49 (group C, P < 0.01) was

关键词： Crohn’s disease Bone mineral density Vertebral fracture Cholecalciferol Calcium Ibandronate sodium fluoride

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Toxicity of sodium fluoride to Caenorhabditis elegans

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Biomedical and Environmental Sciences 2012年第2期25卷 216-223页

作者： LI Qiao ZHANG Shu Hua YU Yuan Hua WANG Li Ping GUAN Shu Wen LI Peng Fei Life Science and Technology Institute Changchun University of Science and Technology Changchun 130022 Jilin China College of Life Science Jilin University Changchun 130021 Jilin China

Objective To investigate the toxic effect of sodium fluoride（NaF） on the nematode Caenorhabditis elegans（***）.Methods Adult *** were exposed to different concentrations of NaF（0.038 mmol/L,0.38 mmol/L,and 3.8 mmol/L） for 24 *** assess the physiological effects of NaF,the brood size,life span,head thrashes,and body bend frequency were *** oxygen species（ROS） and cell apoptosis were detected as parameters of biochemical *** gene expressions were determined by real‐time polymerase chain reaction（PCR） to assess the molecular‐level *** At the physiological level,the brood size of *** exposed to 0.038 mmol/L,0.38 mmol/L,and 3.8 mmol/L concentrations of NaF were reduced by 6%,26%,and 28% respectively in comparison with the control *** maximum life spans of *** exposed to 0.038 mmol/L,0.38 mmol/L,and 3.8 mmol/L concentrations of NaF were reduced by 3 days and 5 days,*** thrashes and body bend frequency both decreased with increasing concentrations of *** the biochemical level,the production of ROS and the incidence of cell apoptosis increased with increasing concentrations of NaF（P0.05）.At the molecular level,different concentrations of NaF exposure raised the expression of stress‐related genes,such as hsp16.1,sod‐3,ctl‐2,dhs‐28,gst‐1,and cep‐*** NaF exposure could induce multiple biological toxicities to *** in a concentration‐dependent *** toxicities may be relevant to the oxidative stress induced by increased ROS production and accumulation in ***.

关键词： sodium fluoride Caenorhabditis elegans Toxicity Real-time PCR

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The leaf extracts of Camellia sinensis (green tea) ameliorate sodium fluoride-induced oxidative stress and testicular dysfunction in rats

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Asian pacific Journal of Reproduction 2020年第6期9卷 267-274页

作者： Dibyendu Ray Sunidhi Roy Pradip Panda Partha Nandi Sandip Mukherjee Subrata Ghosh Department of Physiology Serampore CollegeSeramporeHooghly-712201West BengalIndia Department of Statistics Serampore CollegeSeramporeHooghlyW.B.India Government General Degree College LalgarhJhargramWest BengalIndia Department of Physiology Hooghly Mohsin College(PG Section)HooghlyW.B.Pin 712101India

Objective:To investigate the effect of Camellia(C.)sinensis in mitigating oxidative damage and reproductive toxicity in testis induced by sodium fluoride in a rat ***:Twenty-four adult male Wister rats were divided into 4 groups,with 6 rats in each *** 1 orally received distilled water(1 mL/100 g body weight)daily and served as the control group,while group 2 received drinking water with 100 ppm sodium fluoride per day for 21 consecutive days,group 3 was administered with only *** extract by gavage at a dose of 100 mg/kg body weight and group 4 received drinking water with 100 ppm sodium fluoride and 100 mg/kg body weight *** leaf extract per day for 21 consecutive *** the end of the treatment,the rats were sacrificed under light ether *** gonado-somatic index,sperm count and motility,serum level of luteinizing hormone and testosterone were *** peroxidation[malondialdehyde(MDA)level],nitric oxide(NO)production,and activities of antioxidant enzymes-superoxide dismutase(SOD),catalase,and reduced glutathione level(GSH)were also ***:sodium fluoride treatment significantly decreased gonado-somatic index,sperm count and motility as well as the serum level of luteinizing hormone and testosterone(Psodium fluoride-induced oxidative damage in the testis probably because of its antioxidant property.

关键词： Oxidative stress Testicular damage Camellia sinensis Antioxidant sodium fluoride

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Determination of Trace Iron in High Purity sodium fluoride by Graphite Furnace Atomic Absorption Spectrometry

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Wuhan University Journal of Natural Sciences 2000年第1期5卷 106-108页

作者： QIAN Sha-hua HUANG Gan-quan XUE Ai-fang CHEN Li-hua WANG Mei-lin (College of Chemistry and Environmental Science, Wuhan University, Wuhan, 430072, China) College of Chemistry and Environmental Science Wuhan University Wuhan 430072 China

A method is described for the direct determination of iron in high purity sodium fluoride using graphite furnace atomic absorption spectrometry. Interferences caused by the matrix are investigated. It is shown that the ashing temperature can be increased to 1 400°C and matrix interferences eliminated, the sensitivity of iron increased in 1. 27 fold by the addition of nickel nitrate. The method is applied to the determination of iron in sodium fluoride and satisfactory results are obtained.

关键词： Key words Graphite furnace atomic absorption spectrometry iron determination sodium fluoride matrix modifier

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Folic acid protects against fluoride-induced oxidative stress and testicular damage in rats

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Asian pacific Journal of Reproduction 2021年第6期10卷 274-283页

作者： Ray Dibyendu Chatterjee Tiasa Monalisha Das Panda Pradip Mukherjee Sandip Department of Physiology Serampore CollegeSeramporeHooghly-712201West BengalIndia Department of Statistics Serampore CollegeSeramporeHooghly-712201West BengalIndia

Objective:To investigate the effects of folic acid on testicular oxidative damage in sodium fluoride-induced male Wistar ***:A total of 24 male Wistar rats were divided into 4 groups:the control,sodium fluoride(fed with 100 mg/L sodium fluoride through drinking water orally for 21 days),folic acid(36μg/kg body weight/day,orally),and sodium fluoride plus folic acid(received similar dose orally)*** the end of 21 days,epididymal sperm parameters,biochemical analysis of testicular tissue,and serum hormonal levels were performed along with histopathological ***:sodium fluoride intoxication resulted in marked reduction in gonado somatic index,serum luteinizing hormone,and testosterone level along with 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase *** addition,reduction in sperm density,as well as loss of sperm motility and sperm viability,were also ***,increased levels of testicular malondialdehyde,nitrite,interleukin-6 and tumor necrosis factor-α as well as decreased levels of superoxide dismutase and catalase activities and reduced glutathione content were found to be associated with this *** acid co-treatment,on the other hand,could prevent all the sodium fluoride-induced testicular pathophysiology and oxidative stress related *** examinations of testicular sections from the experimental rats supported these ***:Combining all,this study suggests that being an antioxidant,folic acid plays a beneficial role against fluoride-induced adverse effects on the male reproductive system.

关键词： sodium fluoride Folic acid Testicular damage Sperm Oxidative stress Antioxidants

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