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Histological Features of Parotid Gland of Albino Rats Exposed to. smokeless tobacco

Journal of Northeast Agricultural University(English Edition) 2016年第3期23卷 54-60页

作者： Sana Murtaza Khoso Pervez Ahmed Khoso Navaid Qazi Mir Hassan Khoso Ahmed Sultan Jatoi Ubedullah Kaka Dental College Isra University Hyderabad Sindh Pakistan College of Veterinary Medicine Northeast Agricultural University Harbin 150030 China Shaheed Benazir Bhutto University of Veterinary and Animal Sciences Sakrand Biopharmaceutical Lab College of Life Sciences Northeast Agricultural University Harbin 150030 China

smokeless tobacco is very common personal habit of people living in various areas of Asia which is an alarming sign for the development of different oral diseases in such people. The aim of present study was to investigate effects of smokeless tobacco on parofid glands of the Aalbano rats by using various percentages of the smokeless tobacco. The rats were divided into three different groups, control group （A） no smokeless tobacco, experimental group （B） 5% smokeless tobacco and experimental group （C） 10% of smokeless tobacco with different feeds required according parameters. Weekly weight gain and partid gland were analyzed through student P test and histological structures were recorded through HE stain and Retculin stain. The results showed that as compared to control group body, weight of the rats was decreased in groups B and C having smokeless tobacco percentage in the diet. Weight of parotid gland as compared to control group was decreased in groups B and C with diet of smokeless tobacco. Further, histological observation under HE stain showed that parofid gland of group B showed mild narrowing of ductal lumen, collapse of vessels and stromal was also increased, in group C parenchyrnal tissues with loss of acini found damaged and glandular dystrop and lymphatic infiltration were determined moderate to severe. Meanwhile, reticulin stain showed that vascular collapses were shown because of increasing in stromal glandular atrophy in group C as compared to control group. In conclusion, this study showed that smokeless tobacco caused serious injuries in the tissue level in parotid gland with high percentage of smokeless tobacco which highlight health hazards on its consumption.

关键词： smokeless tobacco histological observation parotid gland Albino rat

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Review with meta-analysis relating North American,European and Japanese snus or smokeless tobacco use to major smoking-related diseases

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World Journal of Meta-Analysis 2022年第3期10卷 130-142页

作者： Peter Nicholas Lee Katharine Jane Coombs Janette Susan Hamling Department of Medical Statistics and Epidemiology P.N.Lee Statistics and Computing LtdSutton SM25DASurreyUnited Kingdom Department of Medical Statistics and Epidemiology RoeLee Statistics LtdSutton SM25DASurreyUnited Kingdom

BACKGROUND While extensive information exists relating cigarette smoking to the risk of lung cancer,chronic obstructive pulmonary disease(COPD),ischaemic heart disease(IHD)or acute myocardial infarction(AMI),and stroke,far less information is available on risks from moist snuff(“snus”)or smokeless tobacco(ST)in United States/Canada,Europe or *** To summarize data from the selected countries on risks of the four diseases associated with current ST or snus *** Publications in English in 1990-2020 were considered that,based on epidemiological studies in North America,Europe or Japan,estimated risks of lung cancer,COPD,IHD/AMI,or stroke according to use of ST or *** studies should involve at least 100 cases of the disease considered,and not be restricted to those with specific other *** literature searches were conducted,selecting papers initially from examination of titles and abstracts,and then from full *** papers were sought from reference lists in selected papers,reviews and *** each disease,relative risk estimates adjusted at least for age were extracted relating ST or snus use to risk,and combined using random-effects *** estimates were mainly for current *** or non-current use,but results for ever vs never use were also *** Seven publications reported results for ST use from six United States *** most useful results came from four studies which provided results for current *** ***-effects meta-analyses of these results showed an increased risk for each disease,clearest for lung cancer(relative risk 1.59,95%confidence interval 1.06-2.39,based on 4 estimates)and COPD(1.57,1.09-2.26,n=3),but also significant(at P<0.05)for IHD(1.26,1.10-1.45,n=4)and stroke(1.27,1.03-1.57,n=4).Also including results for ever *** use from two other studies increased the lung cancer estimate to 1.80(1.23-2.64,n=6),but had little effect on the other *** snus,16 pu

关键词： smokeless tobacco Moist snuff Lung disease Cardiovascular disease Meta-analysis Review

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