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Computed tomography perfusion study of hemodynamic changes and portal hyperperfusion in a rabbit model of small-for-size liver

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Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 74-80页

作者： Zhi-Guo Zhuang,Jian-Rong Xu,Li-Jun Qian,Qiang Xia and Jia-Chang Chi Department of Radiology,and Center of Transplantation,Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200127,China Department of Radiology Shanghai Jiaotong University School of Medicine Shanghai 200127 Shanghai China Center of Transplantation Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai 200127 Shanghai China

BACKGROUND:Portal hyperperfusion in the small-for-size (SFS) liver can threaten survival of ***,it is important to understand the hemodynamic changes in the SFS ***:Twenty rabbits were divided into two groups:a control group and a modulation *** control group underwent an extended *** modulation group underwent the same procedure plus splenectomy to reduce portal blood *** perfusion examinations were performed on all rabbits before and after *** parameter values,especially portal vein perfusion (PVP),were ***:PVP in the modulation group was lower than in the control group after operation (P=0.002).In the control group,postoperative PVP increased by 193.7±55.1% compared with preoperative PVP.A weak correlation was found between the increased percentage of PVP and resected liver-to-body weight ratio (RLBWR) (r=0.465,P=0.033).In the modulation group,postoperative PVP increased by 101.4±32.5%.No correlation was found between the increased percentage of PVP and RLBWR (r=0.167,P=0.644).Correlations were found between PVP and serum alanine aminotransferase,aspartate aminotransferase,and total bilirubin after surgery (Pliver in rabbits by the CT technique.

关键词： computed tomography perfusion portal vein perfusion hemodynamics hepatectomy small-for-size liver

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