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small-cell neuroendocrine carcinoma of the prostate： are heterotransplants a better experimental model？

Asian Journal of Andrology 2010年第3期12卷 308-314,I0007页

作者： Lluis-A. Lopez-Barcons Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center New Orleans LA 70112 USA

small-cell neuroendocrine carcinoma of the prostate （SCNCP） is an uncommon type of prostate cancer. However, it is of clinical importance because it is one of the most aggressive tumors of the prostate with a very poor prognosis. There exist few artificially cultured tumor cell lines to study SCNCE Then, another approach to that study consists in the use of fresh tumor tissue obtained from patients and its heterotransplantation into host mice. The purpose of this review is to integrate data from more than 20 years of heterotransplantation research in the study of small-cell neuroendocrine carcinoma of the prostate （SCNCP）. Heterotransplantation has provided data regarding the histopathology, karyotype, DNA content, cell cycle frequency, tumor markers, androgen receptor expression, metastasis and take rate of this prostate disease. When possible, comparisons between original in situ specimens removed from patients and heterotransplanted tissue from host mice have been made. There are advantages, as well as limitations, that have been identified for SCNCP heterotransplants versus xenotransplantation of cultured cells. Overall, heterotransplanted tumors are better than conventional tumor xenografts at retaining tumor morphology, pathology, secretory activity and expression of tumor markers of the patient＇s original specimen. Furthermore, heterotransplanted tissue preserves the three-dimensional tumor architecture of the prostate to maintain critical stromal-epithelial cell interactions.

关键词： heterotransplant nude mice prostate small-cell neuroendocrine carcinoma xenotransplant

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small-cell neuroendocrine carcinoma of the rectum—a rare tumor type with poor prognosis:A case report and review of literature

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World Journal of Clinical Cases 2020年第23期8卷 6095-6102页

作者： Zhen-Zhou Chen Wang Huang Zheng-Qiang Wei Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China

BACKGROUND small-cell neuroendocrine carcinoma(SNEC)of the rectum is a rare tumor associated with poor *** SUMMARY We report a case of a 77-year-old male who came into our hospital because of blood with his *** endoscopy revealed a cauliflower-like neoplasm in his *** examination showed that the lesion in the upper rectum was likely rectal cancer,and there was no evidence of *** patient was treated with *** examination confirmed SNEC of the rectum and an R0 resection was ***,1 mo after the operation,the patient developed intestinal and ureteral obstructions due to peritoneal ***,the patient died from renal *** SNEC of the rectum is a high-grade carcinoma with an aggressive phenotype,and surgery should be cautiously considered.

关键词： Case report small-cell neuroendocrine carcinoma Rectum Treatment Prognosis Rare tumor

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neuroendocrine carcinoma of the cervix:A comprehensive clinicopathologic study and literature review

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Gynecology and Obstetrics Clinical Medicine 2023年第3期3卷 163-169页

作者： Xiaobo Zhang Mingzhu Li Guo Zhang Danhua Shen Department of Pathology Peking University People's Hospital11 Xizhi Men South StreetXicheng DistrictBeijing100044China Department of Obstetrics and Gynecology Peking University People's Hospital11 Xizhi Men South StreetXicheng DistrictBeijing100044China

Aims neuroendocrine carcinoma of the cervix(NECC)is a rare variant of cervical *** study aims to investigate the clinicopathological features and prognosis of *** A retrospective analysis was conducted on twenty-one patients diagnosed with NECC between May 2008 and September 2021at Peking University People's *** study involved histopathological examination,immunohistochemistry,ThinPrep cytology test(TCT),and high-risk HPV hybrid capture 2(HC2)***-up was conducted through telephone interviews and medical records for a range of 3–160 months,with an average follow-up period of 49.8 *** The average age of the patients was 48.6 years(range:33–69 years).Seventeen patients were diagnosed with neuroendocrine carcinoma through *** cases underwent TCT and HC2 tests before biopsy,and TCT results of four cases showed high-grade squamous intraepithelial lesion(HSIL).High-risk HPV(HR-HPV)positive was detected in seven *** cancer cells exhibited consistent morphological features,including sparse cytoplasm,intensely stained nuclei,and extensive neoplastic *** cases were classified as pure NECC(61.9%),while eight cases were mixed types(38.1%).Three cases were associated with squamous cell carcinoma(SCC),and five cases were associated with *** varied significantly among these subtypes(p<0.05).The overall survival rate in the follow-up period was 66.7%(12/18).Conclusions NECC is an extremely rare and highly aggressive tumor with a poor prognosis,particularly in cases of mixed *** is strongly associated with HPV *** and HPV testing significantly enhance the detection rate before the *** diagnosis of NECC relies on histological and immunohistochemical *** study provides valuable clinical observations on NECC and emphasizes the importance of early detection and accurate diagnosis for improved patient outcomes.

关键词： neuroendocrine carcinoma Cervix small-cell neuroendocrine carcinoma Pathology Clinicopathological features Immunohistochemistry Prognosis

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