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Effects of Shenmai and Aminophylline on Apoptosis of small airway smooth muscle cells and the Expression of Relevant Genes in Rats with Emphysema

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第4期22卷 310-312页

作者：牛汝楫刘辉国傅娟 DepartmentofRespiratoryMedicine

The effects of Shenmai injection (SMI) and am inophylline on apoptosis of sm all airway smooth muscle cells (SASMC) and the Fas/ Fas L expression in rats with papain- induced em physe- ma were *** emphysema model was established by a single intratracheal instillation of *** and Fas/Fas L expression of SASMC were detected by im munohistochemistry SABC and TU NEL assay at day1,3,5 ,7,15 ,30 after modeling,and the effect of SMI and am inophylline on them were *** results indicated that the Fas/Fas L expression positive rate in SASMC was2 .31± 0 .5 5 /1.2 8± 0 .4 *** a single intratracheal instillation of papain,the expression of Fas/Fas L positive rate in the placebo group was increased in a tim e- dependent *** could inhibit the expression of Fas/ Fas L ,but aminophylline couldn't. The positive rate of apoptosis in the control group was 0 .87± 0 .32 .After a single intratracheal in- stillation of papain,the SASMC apoptosis positive rate in the placebo group was increased in a tim e- dependent *** SASMC apoptosis rate in all groups was declined after treatment with SMI,but the effect of am inophylline was *** dem onstrated thatin the patho- genesis of emphysem a Fas/Fas L played an important role in the regulation of SASMC apoptosis. SMI influenced the expression of Fas/ Fas L and declined SASMC apoptosis by inhibiting the releas- ing of inflamm atory m edia and played an im portant role in the therapy of em physema.

关键词： emphysema small airway smooth muscle cells Fas Fas L apoptosis

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