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Regressive Changes of the Myocardial sleeves in Elderly Victims of Sudden Bathtub Death

Forensic Medicine and Anatomy Research 2015年第2期3卷 57-65页

作者： Fumiko Satoh Yoshihisa Seto Akio Tsuboi Motoki Osawa Department of Forensic Medicine Tokai University School of Medicine Isehara Japan

In Japan, most sudden deaths occurring during bathing happen in the winter, and predominantly to elderly people. One can infer a relation to physical conditions that are specific to aging. Atrial fibrillation, an arrhythmia, increases with age. This study examined histological changes in the pulmonary vein myocardial sleeves of sudden bathtub death victims and compared them with those of control individuals. We investigated 35 sudden deaths that occurred during bathing and 34 accidental deaths or deaths caused by diseases unrelated to cardiopathies. Pulmonary veins were excised cross-sectionally from the hilar side to the venoatrial junction. Then they were stained with hematoxylin and eosin, resorcin-fuchsin van Gieson, and Congo-red stains. Amyloid deposits in the pulmonary vein myocardial sleeves, as well as the range and severity of scarring, were graded microscopically on a scale of 0-3. In the sudden bathtub death victims, severe scarring was found in the myocardial sleeves of the four pulmonary veins (mean score, 2.0), which was significantly different (p sleeves. Scarring of the pulmonary vein myocardial sleeves was more advanced in victims of sudden bathtub death than in controls without heart disease. Elderly people with scarring of the pulmonary vein myocardial sleeves are likely to develop degenerative variations in their intra-atrial excitation conduction. These results demonstrate that taking hot baths might induce supraventricular arrhythmias such as atrial fibrillation.

关键词： Sudden Bathtub Death Autopsy Pulmonary Veins Myocardial sleeves Atrial Fibrillation Scarring

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Effect of ivabradine on hyperpolarization activated cation current in canine pulmonary vein sleeve cardiomyocytes with atrial fibrillation

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Journal of Geriatric Cardiology 2008年第1期5卷 39-42页

作者： Yang Li Yan Huang Zongbin Li Hao Wang Jianguo Song Yuqi Liu Lei Gao Shiwen Wang Institute of Geriatric Cardiology Chinese PLA General HospitalBeijing 100853china Institute ofCardiologythe First affilated HospitalXinjiang Medical UniversityUrumqi 830054china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute ofCardiologythe First affilated HospitalXinjiang Medical UniversityUrumqi 830054china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china Institute of Geriatric CardiologyChinese PLA General HospitalBeijing 100853china

Objective To study the effect of ivabradine on hyperpolarization activated cation current in canine pulmonary vein(PY) sleeve cardiomyocytes with atrial *** Dissociation of PVs yielded single cardiomyocytes from a Landengorff column without or with pacemaker activity from long-term rapidly atrial pacing (RAP) *** current was measured with the whole-cell patch-clamp *** Compared with the control group,the rapidly atrial pacing canine PV cardiomyocytes had spontaneous diastolic depolarization and had larger If *** (Iva,1 μM),a selective inhibitor of the If current,markedly reduced If currents in the RAP from -2.66±0.4 pA/pF to -1.58±0.1 pA/pF at the test potential of-120 mV (P＜0.01,n=12).Inhibition effect of Iva of If current showed concentration-dependent range from 0.1 to 10.0μM,with IC50 of 2.2 μ M ( 1.8-2.9 μM,95% CL).Furthermore,V1/ of steady-state activated curve was shifted from -84.3±4.9 mV to -106.9±3.4 mV and k value of steady-state activated curve was changed from 12.1+2.6 mV to 9.9±3.4 mV by the application of.1.0 μM Iva ( P＜0.01,n=12).Conclusions Our study revealed that Ivarbadine may significantly decrease If of rapidly atrial pacing pulmonary vein sleeve ceUs with atrial fibdllation.(J Geriatr Cardiol 2008;5:39-42)

关键词： ivarbadine hyperpolarization activated cation anine pulmonary vein sleeves atrial fibrillation

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Evaluation of Asbestos Exposure Associated with Research Laboratories

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Occupational Diseases and Environmental Medicine 2019年第1期7卷 13-20页

作者： Ediberto Garcia Daniel Newfang Jayme Coyle Giffe T. Johnson Raymond D. Harbison Center for Environmental and Occupational Risk Analysis and Management College of Public Health University of South Florida Tampa FL USA

Asbestos containing materials (ACM) have been used for decades in research laboratory products including gloves, tong sleeves, Transite board, and other materials. These materials typically contain chrysotile asbestos with concentrations ranging up to 80%. The objective of this research was to evaluate asbestos exposure from gloves, tong sleeves, and Transite board with simulated laboratory use. An environmental chamber was used to simulate laboratory application of the products. Bulk samples of various products were tested before and after use. Personal breathing zone air samples as well as one cumulative air sample were collected during testing and followed the National Institute for Occupational Safety and Health (NIOSH) 7400/7402 methodologies. Phase contrast microscopy (PCM) and transmission electron microscopy (TEM) were used for sample analyses. Analysis of air samples using PCM, showed airborne fiber concentrations as high as 0.058 f/cc during use of tongs fitted with asbestos sleeves. Further analysis using TEM showed that the highest airborne fiber concentration was 0.0036 f/cc. Manipulation of Transite board resulted in 8-hour time-weighted-average (TWA) asbestos levels as high as 0.02 f/cc. Testing of various asbestos containing materials used in research laboratories indicate low potential for asbestos fiber exposures.

关键词： Asbestos Exposure Research Laboratories Transite Board Tong sleeves Gloves Chrysotile Asbestos Laboratory Products Asbestos-Related Disease Asbestos-Containing Material

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