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Newborns' sleep-wake cycle development on amplitude integrated electroencephalography

世界儿科杂志:英文版 2016年第3期12卷 327-334页

作者： Xu-Fang Li Yan-Xia Zhou Lian Zhang Department of Neonatology Guangzhou Women and Children's Medical CenterGuangzhouChina Department of Electro-neurophysiology Guangzhou Women and Children's Medical CenterGuangzhouChina

Background:To observe the development of neonatal sleep among healthy infants of different conceptional age(CA)by analyzing the amplitude-integrated electroencephalography(aEEG)of their sleep-wake cycles(SWC).Methods:Bedside aEEG monitoring was carried out for healthy newborns from 32 to 46 weeks CA between September 1,2011 and August 30,2012.For each aEEG tracing,mean duration of every complete SWC,number of SWC repetition within 12 hours,mean duration of each narrow and broadband of SWC,mean voltage of the upper edge and lower edge of SWC,mean bandwidth of SWC were counted and calculated.Analysis of the correlations between voltages or bandwidth of SWC and CA was performed to assess the developmental changes of central nervous system of newborns with different CA.Results:The SWC of different CA on aEEG showed clearly identifiable trend after 32 weeks of CA.The occurrence of SWC gradually increases from preterm to post-term infants;term infants had longer SWC duration.The voltage of upper edge of the broadband decreased at 39 weeks,while the lower edge voltage increases and the bandwidth of broadband declined along with the growing CA.The upper edge of the narrowband dropped while the lower edge rised gradually,especially in preterm stage.The width of the narrowband narrowed down while CA increased.Conclusions:The SWC on aEEG of 32-46 weeks infants showed a continuous,dynamic and developmental progress.The appearance of SWC and the narrowing bandwidth of narrowband is the main indicator to identify the CA-dependent SWC from the preterm to the late preterm period.The lower edge of the broadband identifi es the term to post-term period.

关键词： amplitude-integrated electroencephalography conceptional age development newborn sleep-wake cycle

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The effect of the habenular nucleus lesion on the sleep-wake cycle

The effect of the habenular nucleus lesion on the sleep-wake...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Hsiao-Chang CHAN Epithelial Cell Biology Research Center The Chinese University of Hong KongHong KongChina

＜正＞The neuroanatomy and neurophysiology studies have reported that the habenular nucleus（Hb） has extensive interconnections with many brain areas related to the sleep-wake cycle,especially the hypothalamus,and thus it may play an important regulatory role in the sleep-wake process.In order to understand how the Hb modulates the process,we first examined the expression profile of 123 genes in the hypothalamus after Hb lesion by using Neurotrophin and Receptors Oligo GEArray and followed by confirmation of the expression of the genes well-documented to be associated with sleep-wake cycle in the hypothalamus of Hb-lesioned rats by using RT-PCR.The Electroencephalographic（EEG） response to Hb-lesioned rats was also examined in order to further verify the effect of Hb lesion on the sleep-wake cycle.The microarray results showed that there were 12 genes（approximately 10%of the genes examined） were differentially upregulated expression in the hypothalamus after Hb lesion,which could be grouped into waking-related genes.The subsequent RT-PCR results showed that tryptophan hydroxylase（TPH） and 5-HT-2A,5-HT-2B receptors expression was upregulated in the hypothalamus of Hb-lesioned rats compared to the sham-operated rats.In the EEG experiments,we found that the duration of REMS（dREMS） and the duration of NREMS（dNREM） was reduced and the duration of wakefulness（dwake） was increased in Hb-lesion group as compared to Hb-sham group,as well as in LHb-lesion group as compared to LHb-sham group.However,there were no significant differences between groups in all measurements except for the decrease of dREMS and the increase of dwake between LHb-lesioned rats and LHb sham-operated rats.Taken together,the gene expression profiles and functional studies indicate that Hb,especially LHb,participated in the regulation of sleep and wakefulness process.

关键词： sleep-wake cycle habenular nucleus hypothalamus 5-HT EEG

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EFFECT OF SUANZAOREN DECOCTION ON sleep PHASE IN RATS WITH STATE ANXIETY

EFFECT OF SUANZAOREN DECOCTION ON SLEEP PHASE IN RATS WITH S...

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中国睡眠研究会第十四届全国学术年会

作者： Yue Yang Tingli Li College of Pharmacy Heilongjiang University of Chinese Medicine

Objective: To investigate the effect of Suanzaoren decoction(SZRD) in antagonizing sleep disturbance in state-induced anxiety rats.Methods: SD male rats were selected and randomly divided into blank control group, model group, positive group and SZRD group. Under the conditions of anesthesia and stereotaxic brain, the rats in each group were implanted with EEG electrodes and EMG electrodes in the cortex and neck muscles, and recovered for one week. After the state anxiety was replicated by the conditioned fear, the positive group was given diazepam liquid(3.6 mg/kg), the SZRD group was given water decoction(10 g/kg), and the blank control group and the model were given by gavage. The group was given the same volume of distilled water for 10 consecutive days. The experimental animals in each group underwent EPM behavioral test after the last administration, and then monitored their EEG and EMG data for 24 hours.Results : 1.The effect of SZRD on the behavior of state anxiety rats in EPM.The experimental results showed that compared with the blank control group, Time in open arms and EPM open time%, Open arm entries and EPM open entries% of the rats in the model group were significantly reduced(P0.05).2. The effect of SZRD on the sleep-wake cycle in rats with state anxiety The experimental results showed that compared with the blank control group, the awakening time and wake(%) of the rats in the model group were significantly prolonged(Psleep time and Total(%) were significantly shortened(P0.05);Total sleep time and Total(%) in SZRD grou

关键词： SZRD State anxiety sleep-wake cycle EPM EEG

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The study of function of lateral habenular nucleus in regulating sleepwake cycle

The study of function of lateral habenular nucleus in regula...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Bei-Lin ZHANG~1,Ji-Dong FANG~2,Min HUANG~1,Hua ZHAO~(1,*) 1 Department of Physiology,College of Medicine,Jilin University,Changchun,130021 2 Department of Psychiatry,College of Medicine,Penn State University,Hershy,PA,17033

＜正＞Objective In recent years,the function of the habenular nucleus（Hb） has received considerable attention. Increasing evidence suggests that the Hb may be involved in sleep regulation.The lateral Hb（LHb） has anatomical connections with brain areas involved in sleep regulation,and contains many neurotransmitters/neuromodulator and their receptors involved in the regulation of sleep homeostasis.LHb may also be involved in the circadian regulation of sleep since it not only receives efferent from retina but also displays oscillations of clock genes.The aim of the present study was to determine the contribution of LHb to sleep regulation under normal light-dark cycle（LD）,constant light（LL） and constant dark（DD） conditions,and after sleep deprivation（SD）.Methods Adult male Sprague-Dawley rats（n=22） were implanted with chronic EEG and EMG electrodes for sleep recording and bilateral cannulae into the LHb for LHb lesions. After recovery from surgery and adaptation to the recording system,baseline sleep was recorded for 24 h.Then,the animals received bilateral microinjection of kainic acid（1.5μg/μL） or saline only into LHb.sleep was recorded again for 24 h.sleep was also recorded in some animals after acute shifts to LL and DD conditions or after acute（6 h） SD.sleep data were manually scored in 10-second segments to determine the amounts of wakefulness（W）,rapid eye movement sleep （REMS） and non-REMS（NREMS）.Results（1） LHb lesions significantly increased W（P＜0.001） and decreased NREMS （P＜0.001） during the 24-h period,significantly increased W（P＜0.05） and decreased NREMS（t=4.262,P＜0.01） during the light period,and significantly increased W（P＜0.05） and tend to decrease NREMS and REMS during the dark period. Shame lesion did not cause significant changes in sleep.2.The control rats had less W（P＜0.05） and more NREMS （P＜0.05） under LL compared to LD conditions,whereas the LHb lesion group did not show these changes.Similarly,LHb lesion rats had less sleep alterations in response to acute shift to DD conditions compared to the

关键词： lateral habenular EEG sleep-wake cycle sleep deprivation

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The brain histaminergic system and arousal mechanism

The brain histaminergic system and arousal mechanism

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yi-Ping HOU Lab.Neurobiology,Department of Anatomy,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000, China

＜正＞wakefulness is a functional brain state that allows the performance of several "high brain function",such as diverse behavioural,cognitive and emotional activities.Present knowledge at the whole animal or cellular level suggests that the maintenance of the cerebral cortex in this highly complex state necessitates the convergent and divergent activity of an ascending network with a large reticular zone,extending from the medulla to the forebrain and involving four major subcortical structures（the thalamus,basal forebrain,posterior hypothalamus and brainstem monoaminergic nuclei）,their integral interconnections and several neurotransmitters,such as glutamate,acetycholine,histamine and noradrenaline.In this review,the importance of the thalamus,basal forebrain and brainstem monoaminergic neurons in wake control is briefly summarized,before turning our attention to the posterior hypothalamus and histaminergic neurons have been far less studied.Classical and recent experimental data are summarized,supporting the hypothesis that（1） the posterior hypothalamus constitutes one of the brain ascending activating systems and plays an important role in waking;（2） this function is mediated,in part,by histaminergic neurons,which constitute one of the excitatory sources for cortical activation during waking;（3） the mechanisms of arousal involve both the ascending and descending projection of histaminergic neurons and their interactions with diverse neuronal populations,such as neurons in the pre-optic area and cholinergic neurons;and（4） other widespread-projecting neurons in the hypothalamus also contribute to the tonic cortical activation during wakefulness and/or paradoxical sleep.In the mammalian brain,histamine is synthesized from L-histidine by histidine decarboxylase and is predominantly inactivated by histamine-N-methyltransferase.The central actions of histamine are mediated by post-synaptic H1- and H2-receptors and by H3-receptors possessing characteristics of auto- and heteroreceptors. In addition to a large body of

关键词： histaminergic system sleep-wake cycle

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Basal ganglia control of sleep-wake behavior

Basal ganglia control of sleep-wake behavior

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Ramalingam Vetrivelan Patrick M.Fuller Department of Neurology Beth Israel Deaconess Medical Center and Harvard Medical SchoolBoston 02215USA

＜正＞The basal ganglia are involved in a myriad of neurobiological processes that operate on the basis of wakefulness, including motor function,learning,emotion and addictive behaviors.We hypothesized that the basal ganglia play an important role in the regulation of wakefulness.To test this prediction,we made cell-body specific lesions in the striatum and globus pallidus（GP） using ibotenic acid.We found that rats with striatal（caudoputamen） lesions exhibited a 14.95% reduction in wakefulness and robust fragmentation in sleep-wake behavior i.e.,increased the number of state transtions between non-rapid eye movement（NREM） sleep and wakefulness and elimination of nocturnal ultra-long wake bouts（＞ 120 min,2-3 per night in control）.These lesions also resulted in a reduction in diurnal variation of sleep-wakefulness.On the other hand,the lesions of accumbens core（NAc） resulted in a 26.72%increase in wakefulness and a reduction in NREM sleep bout duration.In adition,the rats with NAc lesions exhibited the obsessive-compulsive disorder-like behaviors such as excessive digging and scratching.Bilateral GP lesions produced a robust increase in wakefulness（45.52%） and frequent sleep-wake transitions and a decrease in NREM sleep bout duration.Finally,the lesions of the subthalamic nucleus or the substantia nigra reticulate produced minor changes in the amount of sleep-wakefulness without altering the sleep architecture.Colletively,our results suggest that the basal ganglia are a part of neural circuitry controlling sleepwakefulness and that cortico-striato-pallidal loop may regulate cortical arousal.

关键词： Globus pallidus striatum Ibotenic acid sleep-wake cycle ultradian

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A novel hypnotic compound,WS997,shortened NREM sleep latency and increased NREM sleep time in mice

A novel hypnotic compound,WS997,shortened NREM sleep latency...

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中国神经科学学会第十届全国学术会议

作者： Jing-Wen DONG Yuan SHI Li-Na TANG Jian-Jun ZHANG State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences ＆ Peking Union Medical College

Objective WS997 is a novel synthetic compound with hypnotic properties.In our previous study,WS997（60 mg/kg,i.p.） significantly shortened the sleep latency and prolonged the total sleep time in mice.sleep is a highly organized behavioral and physiologic state,which is typically defined based on either behavioral or electroencephalogram（EEG） characteristics and can be classified as one of two basic forms:the non-rapid eye movement（NREM） sleep and rapid-eye movement（REM） sleep.In order to further characterize the effects of WS997on sleep-wakefulness patterns in mice,here we introduced the changes in EEG and EEG spectra.Methods The EEG and electromyography（EMG） were simultaneously and continuously recorded for 7 h in freely moving mice in constant darkness.Changes occurring in cortical EEG and sleep-wake states architecture were examined.Results After injection of WS997（60 mg/kg,i.p.）,NREM sleep latency was significantly reduced compared to vehicle.WS997（60 mg/kg,i.p.）increased NREM sleep,as well as the NREM sleep delta power.The NREM sleep for 3 hours was increased from 80.9min to 174.5 min,and the increasing rate was 115.8%.The REM sleep was significantly decreased from 15.2 min to 4.7min,and the decreasing rate was 69.2%.EEG power was increased at delta frequencies（＜5Hz）,the peak increase being at 1-2 Hz,and was significantly decreased at higher frequencies（＞6 Hz）,which showed an inhibition pattern on the cortex firing.Conclusion WS997 exhibited clear-cut sleep-promoting effects in mice,including shortened NREM sleep latency and increased NREM sleep time.

关键词： sleep electroencephalogram non-rapid eye movement sleep-wake cycle hypnotic

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Roles of Dopamine D1 Receptor-expressing Neurons in the Nucleus Accumbens in the Regulation of wakefulness in Mice

Roles of Dopamine D1 Receptor-expressing Neurons in the Nucl...

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中国睡眠研究会第九届学术年会

作者： LUO Yan-Jia WANG Lu LI Ya-Dong YUAN Xiang-Shan QU Wei-Min HUANG Zhi-Li Department of Pharmacology Fudan University State Key Laboratory of Medical Neurobiology Fudan University The Institutes of Brain Science and Collaborative Innovation Center for Brain Science Fudan University

OBJECTIVE The nucleus accumbens(NAc),a part of basal ganglia,has been reported to play a role in motivation and reward.Dysfunction of NAc causes numerous neurological disorders associated with sleep-wake disturbances.There are two different subpopulations of principle projection neurons in the NAc,dopamine D receptor(R)-expressing medium spiny neurons(DR-MSNs)and DR-MSNS,both of which are GABAergic MSNs.However,whether NAc DR-MSNs are involved in

关键词： Dopamine D1 receptor nucleus accumbens optogenetics chemogenetics sleep-wake cycle

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