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Experimental Study on Topical Treatment of Diabetic skin ulcers with Yi Medicine "Yi Bu A Jie(以布阿节)”Extract

Chinese Journal of Integrative Medicine 2013年第6期19卷 464-467页

作者：卢莉莉万平李利珍赵梅君胡佳耀赵咏芳 Department of Biology College of Life and Environmental SciencesShanghai Normal University Laboratory of Bone and Joint Pathology State Administration of Traditional Chinese MedicineShanghai Shuguang Hospital

Objective： To study the role and mechanism of the Yi medicine, Yi Bu A Jie （以布阿节） extract, in topical treatment of diabetic skin ulcers, with a view to finding a breakthrough natural drug for the prevention and treatment of diabetic skin ulcers. Methods： A model of diabetic skin ulcers in Kunming mice was developed. Yi Bu A Jie was extracted in a Soxhlet extractor. Two different concentrations of the extract （0.005 mg/mL and 0.01 mg/mL） were applied to the wound of diabetic skin ulcers once every 3 days, and local skin appearance and histopathological changes were observed. Resalts： The shortest healing time was 25.25 ±2.06 day with a low concentration （P=0.0037 compared with the high concentration group, 33.14＋2.21 day; P=0.0082 compared with control group, 28.21 ± 2.14 days）. The longest healing time was in the high concentration group （P=0.0025 compared with the control group）. In both groups, a large number of inflammatory neutrophil cells were exuded dudng the experimental period. In the low concentration group, capillary-rich granulation tissue and actively growing fibroblasts appeared in the wound, while there was much necrotic tissue in the high concentration group. Conclusion： Yi Bu A Jie extract has an inhibitory effect on diabetic skin ulcers in mice, and the low concentration is more suitable.

关键词： Yi Bu A Jie topical therapy diabetes skin ulcers

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Microbiological and Histological Examinations of Endangered Neurergus kaiseri Tissues Displaying Red-leg Syndrome

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Asian Herpetological Research 2014年第3期5卷 204-208页

作者： Paria PARTO Zahra M.S.HAGHIGHI Somaye VAISSI Mozafar SHARIFI Department of Biology Faculty of Science Razi University Faculty of Veterinary Science Department of basic Science Razi University

Presence of the red leg syndrome （RLS） was documented through bacterial and histological examinations in the endangered Kaiser＇s mountain newt Neurergus kaiseri obtained from a pet shop. The individuals which were severely infected showed lethargy, appetite loss, weight loss, abdominal skin redness and skin ulcers on hind legs. This study reveals the presence of two bacteria causing RLS on the skin of captive AT. kaiseri including Proteus vulgaris and Bacillus cereus. Sections of skin in affected areas and internal organs were examined through standard histological procedures. Histologically, epidermal necrosis and ulcers, epidermal gland depletion, myositis and subcutaneous edema, gastric submucosal edema and hepatomegaly were seen. There were also correlations between the microbial infection and structural changes in tissues of Kaiser＇s mountain newt. The severity of the structural changes are related to the level of microbial infection in the target organs and could be sustained by the isolation of P. vulgaris and other pathogens. The presence of the infective bacterial population and their interaction on the skin of the newt may have changed the normal skin flora and facilitate the prevalence of other disease.

关键词： Neurergus kaiseri red-leg syndrome lethargy abdominal skin redness skin ulcers

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