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Microstructural changes in memory and reticular formation neural pathway after simple concussion

Neural Regeneration Research 2012年第28期7卷 2206-2212页

作者： Lin Ouyang Rongyue Shi Yuhui Xiao Jiarong Meng Yihe Guo Guangming Lu Department of Radiology the 175 Hospital of Chinese PLA (Southeast Hospital Affiliated to Xiamen University) Zhangzhou 363000 Fujian Province China Department of Pathology the 175 Hospital of Chinese PLA (Southeast Hospital Affiliated to Xiamen University) Zhangzhou 363000 Fujian Province China Department of Medical Imaging Nanjing General Hospital of Nanjing Military Command Nanjing 210002 Jiangsu Province China

Patients with concussion often present with temporary disturbance of consciousness. The microstructural and functional changes in the brain associated with concussion, as well as the relationship with transient cognitive disorders, are currently unclear. In the present study, a rabbit model of simple concussion was established. Magnetic resonance-diffusion tensor imaging results revealed that the corona radiata and midbrain exhibited significantly decreased fractional anisotropy values in the neural pathways associated with memory and the reticular formation. In addition, the apparent diffusion coefficient values were significantly increased following injury compared with those before injury. Following a 1-hour period of quiet rest, the fractional anisotropy values significantly increased, and apparent diffusion coefficient values significantly decreased, returning to normal pre-injury levels. In contrast, the fractional anisotropy values and apparent diffusion coefficient values in the corpus callosum, thalamus and hippocampus showed no statistical significant alterations following injury. These findings indicate that the neural pathways associated with memory and the reticular formation pathway exhibit reversible microstructural white matter changes when concussion occurs, and these changes are exhibited to a different extent in different regions.

关键词： brain microstructural white matter MRI diffusion tensor imaging simple concussion consciousness disturbance brain injury reversibility regeneration neural regeneration

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Quiet rest ameliorates biochemical metabolism in the brain in a simple concussion rabbit model Evaluation of hydrogen proton magnetic resonance spectroscopy

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Neural Regeneration Research 2011年第33期6卷 2617-2621页

作者： Lin Ouyang Yuhui Xiao Cui Yue Junpeng Ma Rongyue Shi Lin Gao Yihe Guo Jiarong Meng Qianxin Jia Department of Radiology the 175 Hospital of Chinese PLA （Southeast Hospital Affiliated to Xiamen University） Zhangzhou 363000 Fujian Province China Department of Pathology the 175 Hospital of Chinese PLA （Southeast Hospital Affiliated to Xiamen University） Zhangzhou 363000 Fujian Province China

The present study analyzed changes in the biochemical metabolites N-acetyl aspartate, choline, and creatine in a simple concussion rabbit model following quiet rest, hyperbaric oxygen therapy, or interference stimulation through the use of hydrogen proton magnetic resonance spectroscopy detection. Experimental findings showed that brain N-acetyl aspartate and choline peak values significantly decreased, while creatine peak values significantly increased following simple concussion. Following treatments, N-acetyl aspartate and choline peaks returned to normal levels in the quiet rest and hyperbaric oxygen therapy groups, but no changes were observed in the interference stimulation group. Results demonstrated abnormal changes in the brain biochemical metabolism environment following simple concussion. Quiet rest was shown to play an important role in restoration of biochemical metabolism following simple concussion.

关键词： biochemistry brain hydrogen proton magnetic resonance spectroscopy hyperbaric oxygen interference stimulation metabolism neural regeneration quiet rest simple concussion

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